Designs for more robust microbial strains
Microbial robustness is important for sustainable and efficient biotechnology-based production. Producer strains created in the laboratory do not always respond well to industrial conditions like large fermentation volumes, accumulation of toxic intermediates and media acidification. The Marie Skłodowska-Curie Actions (MSCA) project BioCircus will address the issue caused by the lack of robustness in engineered microbial strains. Specifically, it will explore the construction of biosensor and dynamic regulation circuits that measure and control the production of the target molecule. It will also use machine learning predictive models and automation to improve these circuits. Naringenin, a key molecule of the flavonoid family, will be used as proof-of-principle molecule. E. coli will be used as model organism.
Fields of science
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensors
- social scienceseconomics and businesseconomicssustainable economy
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
- engineering and technologyindustrial biotechnologybioprocessing technologiesfermentation
- natural sciencesbiological sciencesmolecular biology
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding SchemeHORIZON-AG-UN - HORIZON Unit Grant
46980 Paterna Valencia
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.