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Immunometabolic regulation of the host response to viral infection in the context of obesity

Project description

The link between obesity and severe viral infections

Humans who are obese have significantly higher risk of developing more severe symptoms due to viral infection. The reason for this is not well understood. Studies on mice found that the obese mice developed profound and progressive loss of fat and muscle in response to chronic viral infection. In this context, the Marie Skłodowska-Curie Actions project Virobe will identify the mechanisms driving this marked and progressive tissue wasting in infected obese mice. Specifically, it will test whether that the tissue wasting during viral infection results from disrupted glucose homeostasis, perturbations in macrophage functions and from abnormal cytokine profiles observed in the context of obesity. The findings will shed light on potential therapeutic strategies aiming at improving the outcome of viral disease in obese persons.

Funding Scheme

MSCA-PF -

Coordinator

KOBENHAVNS UNIVERSITET
Net EU contribution
€ 214 934,40
Address
Norregade 10
1165 Kobenhavn
Denmark

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
No data