Project description
The link between obesity and severe viral infections
Humans who are obese have significantly higher risk of developing more severe symptoms due to viral infection. The reason for this is not well understood. Studies on mice found that the obese mice developed profound and progressive loss of fat and muscle in response to chronic viral infection. In this context, the Marie Skłodowska-Curie Actions project Virobe will identify the mechanisms driving this marked and progressive tissue wasting in infected obese mice. Specifically, it will test whether that the tissue wasting during viral infection results from disrupted glucose homeostasis, perturbations in macrophage functions and from abnormal cytokine profiles observed in the context of obesity. The findings will shed light on potential therapeutic strategies aiming at improving the outcome of viral disease in obese persons.
Fields of science
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- medical and health sciencesbasic medicinephysiologyhomeostasis
- medical and health scienceshealth sciencesnutritionobesity
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
MSCA-PF -Coordinator
1165 Kobenhavn
Denmark
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