Project description
Discovering effective vaccine against human schistosome infection
Neglected tropical schistosomiasis affects millions of people, causing 300 000 deaths in Africa alone. The cure with schistosomicidal drugs is complicated by reinfection after exposure to contaminated water. While partial natural immunity only develops after decades of infection, the vaccine is not available. Funded by the Marie Skłodowska-Curie Actions programme, the ReCHISVac project aims to create an effective vaccine against human schistosomiasis. The study will use unique samples from controlled repeat Schistosoma mansoni infection models to identify novel antigens and protective cellular and cytokine responses. These data will be verified in comparative analysis to samples from naturally infected individuals. The identified antigens will be utilised in a preclinical development plan for translation into new treatment against schistosomiasis.
Objective
Schistosomiasis is a neglected tropical disease afflicting over 200 million people and causing 300,000 deaths in Africa alone. Whilst infections can be cleared with schistosomocidal drugs, individuals will become rapidly re-infected upon exposure to contaminated water. Partial immunity only develops naturally only after decades of constant infection, and there is no vaccine. Previous schistosome vaccine studies have been flawed, due to a lack of understanding of what constitutes a protective immune response, focus on single antigen targets, and a lack of pharmaceutical industry support or expertise for development.
Here, I propose to use unique samples from repeat Schistosoma mansoni controlled human infection (Sm-CHI) models to reveal novel antigens and corresponding cellular and cytokine responses that are protective against schistosomiasis. To evaluate how well this protective signature will translate to endemic countries, matched analyses will be performed in samples from naturally schistosome infected Ugandan individuals. Antigen-specific antibody and cellular immunology data will be combined utilising bioinformatic tools to reveal a signature of multiple antigens and immune responses associated with protection from schistosomiasis. Next, in a non-academic placement at Batavia Biosciences, I will develop a pre-clinical development plan to translate the identified protective immune signature into an effective vaccine against human schistosomiasis. This fellowship will form the basis of my future career development, to become an independent researcher in the field of schistosome vaccinology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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2333 ZA Leiden
Netherlands
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