Project description
Hypoxia and mechanical instability targeted in bone regeneration
Healing and bone regeneration after fracture is often impaired due to lack of oxygen on rupture of blood vessels and mechanical instability. The progenitor cells that form the cartilage and bone must therefore adapt to hypoxic conditions and an unstable microenvironment. Knowledge about how the crosstalk between the molecules in these two pathways is sparse. The EU-funded HIPPOX project aims to define the mechanisms that mediate crosstalk between hypoxia and mechanical signalling and target this crosstalk with regenerative therapies to accelerate healing. Improvements in fracture healing will benefit patients globally, reducing hospitalisation and mortality in the elderly.
Objective
Bone regeneration is a challenging clinical problem. Each year, millions of patients worldwide experience bone fracture: one every two-to-three seconds. Over 10-15% of these fractures suffer from impaired healing. Especially the elderly population is disproportionately affected being associated with permanent impairment and increased mortality. Two critical events early in fracture repair determine the outcome of the healing process: lack of oxygen caused by blood vessel rupture and mechanical instability. Thus, the progenitor cells that will eventually form cartilage and bone to heal the fracture must simultaneously adapt to both hypoxic and mechanical microenvironments to ensure full tissue restoration. Cellular hypoxia-induced signaling and mechanotransduction are therefore critical to bone healing, but how crosstalk between these pathways impacts fracture repair is unknown. The project aims to define new cellular and molecular mechanisms that mediate crosstalk between hypoxia and mechanical signaling during fracture repair and target this crosstalk in an innovative regenerative therapy to accelerate fracture repair. Improvement in therapeutic strategies and rehabilitation will have a global impact and are already included in European health care efforts to ensure health throughout the life course, and to reduce hospitalization time and mortality in the (elderly) population. The project will be conducted in the McKay Research Laboratory, University of Pennsylvania, United States (PENN), the Department of Chemistry, Materials and Chemical Engineering G. Natta, Politecnico di Milano, Italy (POLIMI, secondment) and the Centre for Translational Bone, Joint and Soft Tissue Research, Technische Universitt Dresden, Germany (TUD).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
01069 DRESDEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.