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Development of a point-of-care microfluidic device for Therapeutic Drug Monitoring in cancer treatment (POC-TDM)

Descripción del proyecto

Combinar la ingeniería microfluídica con la investigación oncológica

La quimioterapia es un tratamiento antineoplásico que se receta para tratar de eliminar las células cancerosas. Con todo, los protocolos de quimioterapia son genéricos, por lo que no permiten tener en cuenta las diferencias entre pacientes con respecto a la farmacocinética de los antineoplásicos. En el proyecto POC-TDM, financiado por las Acciones Marie Skłodowska-Curie, se estudiará la posibilidad de mejorar y personalizar la quimioterapia antineoplásica. Por ejemplo, si no se alcanza la concentración sanguínea objetivo, se producirá una resistencia al fármaco o efectos secundarios no deseados. Por ello, la supervisión de fármacos antineoplásicos podría ser fundamental para mejorar y personalizar la quimioterapia. De hecho, el proyecto propone un nuevo método basado en un chip microfluídico para determinar de forma rápida las concentraciones plasmáticas de fármacos antineoplásicos comunes. Este novedoso sistema podría mejorar las tasas de supervivencia de los pacientes oncológicos a través de una terapia personalizada.

Objetivo

Cancer claims almost 10 million lives annually, making it one of the major causes of death around the world. Despite the development of novel drugs and treatment options, the 5-years survival of the most common cancers are still strikingly low. Chemotherapy (CT) is a widely used option to treat malignancies, however CT protocols are established on a “one size fits all” basis and ignore inter-patient differences in drug pharmacokinetics which influence the blood levels of anticancer drugs, therefore leading to improper dosing in 50% of patients. Missing target blood concentration will lead to drug resistance and/or unwanted side effects. Therapeutic Drug Monitoring (TDM) could be the key to improve and personalize CT, however the lack of an affordable point-of-care (POC) method is preventing its introduction to oncology. Mass spectrometry (MS) is the golden standard analytical approach to determine blood drug levels, but the instrument and specialized expertise to operate it are rarely available in the clinical environment. The high volume of blood required for MS analysis is also a challenge, because cancer patients are regularly weakened. Exploiting the strong and specific fluorescence of anthracyclines, the most used CT agents, we propose a radically new microfluidic chip-based approach to rapidly determine plasma concentrations of several widely applied anticancer drugs. Microvolume plasma separation and collection from a drop of blood (>50 ul) will be done with a specifically designed chip, then plasma anthracycline concentration will be measured using a compatible spectrophotometer. The approach will be validated using clinically relevant mouse tumour models and with samples from veterinary cancer patients. This interdisciplinary project, combining microfluidic engineering with cancer research, will introduce a novel POC-TDM system which could change CT treatments and improve survival through patient-tailored therapy.

Régimen de financiación

HORIZON-AG-UN - HORIZON Unit Grant
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Coordinador

ENERGIATUDOMANYI KUTATOKOZPONT
Aportación neta de la UEn
€ 157 622,40
Dirección
Konkoly thege miklos ut 29-33
1121 Budapest
Hungría

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Región
Közép-Magyarország Budapest Budapest
Tipo de actividad
Research Organisations
Enlaces
Aportación de la UE
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