Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA)

Información del proyecto

BacTheRNA

Identificador del acuerdo de subvención: 101065819

DOI

10.3030/101065819

Proyecto finalizado el 7 Noviembre 2023

Fecha de la firma de la CE 21 Junio 2022

Fecha de inicio 16 Julio 2022

Fecha de finalización 15 Mayo 2024

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 172 750,08

Coordinado por

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

Periodic Reporting for period 1 - BacTheRNA (Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA))

Período documentado: 2022-07-16 hasta 2024-05-15

Resumen del contexto y de los objetivos generales del proyecto

Probiotic bacteria are beneficial to the host in several ways. The final goal of BacTheRNA is the development of novel RNA-based therapeutics using probiotic bacteria. These can be used as a biological production factory for RNA therapeutics, at a cheaper cost than chemical synthetic routes. Due to their being harmless and food-grade, they represent a safe and low-cost alternative to current methods.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

This project was terminated early so it did not reach its full objectives and potential. However, in the months of implementation, preliminary results were achieved that could set the basis for further research. A suitable probiotic strain was selected, and DNA plasmids were designed (but not tested or validated) to perform subsequent experiments. Particular RNA targets naturally produced by these bacteria were also studied, yielding preliminary results.

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Due to the short duration of the project, the impact could not be fully achieved. The results achieved are preliminary.