Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA)

Projektinformationen

BacTheRNA

ID Finanzhilfevereinbarung: 101065819

DOI

10.3030/101065819

Das Projekt endete am 7 November 2023

EK-Unterschriftsdatum 21 Juni 2022

Startdatum 16 Juli 2022

Enddatum 15 Mai 2024

Finanziert unter

• Marie Skłodowska-Curie Actions (MSCA)

Gesamtkosten

Keine Daten

EU-Beitrag

€ 172 750,08

Koordiniert durch

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

Periodic Reporting for period 1 - BacTheRNA (Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA))

Berichtszeitraum: 2022-07-16 bis 2024-05-15

Zusammenfassung vom Kontext und den Gesamtzielen des Projekts

Probiotic bacteria are beneficial to the host in several ways. The final goal of BacTheRNA is the development of novel RNA-based therapeutics using probiotic bacteria. These can be used as a biological production factory for RNA therapeutics, at a cheaper cost than chemical synthetic routes. Due to their being harmless and food-grade, they represent a safe and low-cost alternative to current methods.

Arbeit, die ab Beginn des Projekts bis zum Ende des durch den Bericht erfassten Berichtszeitraums geleistet wurde, und die wichtigsten bis dahin erzielten Ergebnisse

This project was terminated early so it did not reach its full objectives and potential. However, in the months of implementation, preliminary results were achieved that could set the basis for further research. A suitable probiotic strain was selected, and DNA plasmids were designed (but not tested or validated) to perform subsequent experiments. Particular RNA targets naturally produced by these bacteria were also studied, yielding preliminary results.

Fortschritte, die über den aktuellen Stand der Technik hinausgehen und voraussichtliche potenzielle Auswirkungen (einschließlich der bis dato erzielten sozioökonomischen Auswirkungen und weiter gefassten gesellschaftlichen Auswirkungen des Projekts)

Due to the short duration of the project, the impact could not be fully achieved. The results achieved are preliminary.