Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA)

Informacje na temat projektu

BacTheRNA

Identyfikator umowy o grant: 101065819

DOI

10.3030/101065819

Realizacja projektu zakończyła się 7 Listopada 2023

Data podpisania przez KE 21 Czerwca 2022

Data rozpoczęcia 16 Lipca 2022

Data zakończenia 15 Maja 2024

Finansowanie w ramach

• Marie Skłodowska-Curie Actions (MSCA)

Koszt całkowity

Brak danych

Wkład UE

€ 172 750,08

Koordynowany przez

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland

Periodic Reporting for period 1 - BacTheRNA (Bacterial-Derived Therapeutics based on CircRNAs (BacTheRNA))

Okres sprawozdawczy: 2022-07-16 do 2024-05-15

Podsumowanie kontekstu i ogólnych celów projektu

Probiotic bacteria are beneficial to the host in several ways. The final goal of BacTheRNA is the development of novel RNA-based therapeutics using probiotic bacteria. These can be used as a biological production factory for RNA therapeutics, at a cheaper cost than chemical synthetic routes. Due to their being harmless and food-grade, they represent a safe and low-cost alternative to current methods.

Prace wykonane od początku projektu do końca okresu sprawozdawczego oraz najważniejsze dotychczasowe rezultaty

This project was terminated early so it did not reach its full objectives and potential. However, in the months of implementation, preliminary results were achieved that could set the basis for further research. A suitable probiotic strain was selected, and DNA plasmids were designed (but not tested or validated) to perform subsequent experiments. Particular RNA targets naturally produced by these bacteria were also studied, yielding preliminary results.

Innowacyjność oraz oczekiwany potencjalny wpływ (w tym dotychczasowe znaczenie społeczno-gospodarcze i szersze implikacje społeczne projektu)

Due to the short duration of the project, the impact could not be fully achieved. The results achieved are preliminary.