Objective
Organic synthesis, the culminating point of many areas, is greatly beneficial to European development of emerging technologies and asymmetric catalysis is amongst the most challenging but very powerful method to access enantiopure molecules. Provide new methods to access enantiopure compounds is of high interest when it comes, for instance, to drug delivery. More than 40% of the new drugs approved by the FDA in 2015 bear chiral amine (20% in 2005). This increasing need to access chiral amines and its precursors resonates as a call to chemists to pave new routes for the elaboration of these derivatives. Despite the versatile nature of the nitro group, readily converted into amines or many other pharmaceutically relevant functionalities, no direct asymmetric nitrative process has been reported to date. Herein, ASYNO2 aims to merge photoredox or electrochemical with asymmetric organo- or acid-catalysis for the development of the first asymmetric nitration reactions. Despite this synthetic challenge, novel and very promising routes, along with the support of computational studies are considered and discussed in details in this research plan. Preliminary results provided proof of concept at the synopsis of this collaborative work between the Laboratory of Catalysis and Organic Synthesis of the University of Fribourg (UniFr, photo- and electrochemistry, asymmetric synthesis expertise, Outgoing phase) and the Institute of Chemistry of Poitiers (IC2MP – UMR CNRS 7285 – France, Superacid and NMR expertise, return phase). Superacid chemistry is only mastered by very few research groups in the world and is a European specificity of the group at Poitiers and will be applied for the first time to asymmetric catalysis. Furthermore, this program will provide a prolific fellow with an internationally competitive training, with the aim of advancing the career of an autonomous scientist in the EU and the next generation of multidisciplinary researchers in pharmaceutical sciences.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been validated by the project's team.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.