Descripción del proyecto
El papel de la exposición a sustancias químicas en el desarrollo de la diabetes gestacional
La prevalencia de la diabetes gestacional (DG) ha aumentado de forma dramática en los últimos decenios. Hoy día, se diagnostica esta enfermedad en el 7-10 % de todos los embarazos. Existe una falta de conocimientos sobre la multitud de sustancias químicas a las que están expuestos los seres humanos, así como sobre sus efectos, sobre todo durante el embarazo. En el proyecto MANGO, financiado por las Acciones Marie Skłodowska-Curie, se estudiarán los efectos de la exposición a sustancias químicas durante el embarazo, prestando especial atención a la DG. Sus investigadores determinarán la presencia de sustancias químicas en muestras biológicas de cuatrocientas mujeres embarazadas y evaluarán la relación entre la exposición a sustancias químicas y los datos clínicos. El objetivo es poner en práctica un programa piloto para minimizar la exposición a sustancias químicas peligrosas durante el embarazo.
Objetivo
There is a lack of knowledge on the multitude of chemicals that we are exposed to, and even less is known about the exposure during pregnancy, the most critical window for adverse health effects on both mother and offspring. In turn, the prevalence of Gestational Diabetes Mellitus (GDM) has incredibly increased during the last decades and it is now diagnosed in up to 18% of the pregnancies. In this context, I propose the project “The Chemical Exposome of Pregnant Women with Gestational Diabetes Mellitus (MANGO)” to be co-supervised by Dr. Navas-Acien and Prof. Gary Miller at Columbia Mailman School of Public Health (USA, Third Country for the outgoing phase), and by Prof. Domingo at Universitat Rovira i Virgili (URV, Spain, beneficiary institution and host for the incoming phase). The main scientific goals of MANGO are: (1) to determine the occurrence of non-target chemicals in biological samples of 400 pregnant women; (2) to evaluate the association between the exposure to chemicals and clinical data, exploring the effect modification by sociodemographic, dietary and lifestyle factors; (3) to implement a pilot prevention programme to minimize the exposure to hazardous chemicals during pregnancy. These objectives will be tackled by integrating last advances in high-resolution mass spectrometry (WP1), mathematical models (WP2) and risk assessment and prevention strategies (WP3). MANGO will leverage biological samples of Diabetes and Pregnancy Cohort from Institut d’Investigació Sanitària Pere Virgili/Hospital Universitari Joan XXIII (IISPV/HJXXIII, associated partner) and will return the knowledge to Europe by implementing the first pilot programme to increase the awareness of the exposure to hazardous chemicals. Through this MSCA-PF-GF, my training in environmental epidemiology in USA would capitalize upon my skills on non-target chemical analysis (MSCA cofund in INSULIN Tecniospring), facilitating the start of a new research line and a track-tenure at URV
Ámbito científico
- medical and health scienceshealth sciencespublic healthepidemiology
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineobstetrics
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
- medical and health sciencesbasic medicinetoxicology
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global FellowshipsCoordinador
43003 Tarragona
España