Descripción del proyecto
Una intervención regenerativa para las lesiones medulares
Las lesiones medulares suelen estar causadas por traumatismos y afectan a millones de personas en todo el mundo. En la actualidad, no existen métodos probados para restaurar la función tras una lesión medular, y los tratamientos se centran más en la neuroprotección que en la regeneración. El equipo del proyecto MINECHPS-SCI, financiado por las Acciones Marie Skłodowska-Curie, propone desarrollar un método combinado para potenciar la regeneración de la médula espinal tras una lesión. La estrategia consiste en inyectar hidrogeles electroconductores que contienen neurotrofinas para fomentar la neuroplasticidad y citocinas antiinflamatorias para reducir la inflamación. La aplicación de estimulación eléctrica y láser de infrarrojo cercano fomentará aún más la regeneración de neuronas y células gliales, lo cual podría revertir la degeneración de la médula espinal.
Objetivo
Spinal cord injury (SCI) is a debilitating health conditions affecting circa 27.04 million people globally including 6.4 million Europeans with serious impact on the quality of life and socio-economic status of the patients. Existing regenerative and rehabilitation approaches are largely palliative and neuroprotective, targeting the spared neural tissue after injury with limited efficacy in regeneration. While the spinal cord has poor regenerative ability, the degenerative processes further complicate the SCI pathophysiology. Hence, no regenerative and rehabilitation approaches, individually, have resulted in complete and near complete functional recovery to date. To fully restore the injured spinal cord's functionality, a coordinated combinational approach addressing particular degenerative processes is necessary. Herein, the fellow proposes to develop a regenerative-rehabilitation combinational approach to maximize the functional regenerative outcome after SCI using minimally invasive injectable electroconductive hydrogels (ECHs) functionalized with neurotrophins (NTs) and anti-inflammatory cytokines in combination with electrical stimulation (ES) and near infrared (NIR) laser stimulation. ES and NIR laser through the ECH will be used to stimulate the neurons and glial cells to enhance regeneration and neuroplasticity as well as for on demand delivery of biologics to target the inhibitory processes. This proposal describes the project's multidisciplinary nature, execution and management of the project by the fellow and the multiple collaborators who will each provide the fellow with cutting-edge research skills. The goals of the fellow’s project place specific focus to ensure that the training of the fellow brings him to a level of competitive scientific excellence at international level.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinador
D02 CX56 DUBLIN 2
Irlanda