Novel methods to identify neurotoxic chemicals and their mechanism of action
The incidence of neurodevelopmental disorders is increasing among children, and this trend has been linked to man-made chemicals and developmental neurotoxicity (DNT). The current guidelines are insufficient to properly identify chemicals that are toxic to the developing brain. Funded by the Marie Skłodowska-Curie Actions programme, the neurOmics project aims to find new, more sensitive and reliable approaches to evaluate endocrine DNT-induced disruptions. The study will employ molecular methods and omics technologies to test the hypotheses that lipids and myelination represent targets for endocrine-disrupting DNT. High-resolution mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging will provide a more reliable measurement of fluctuating hormone levels. The objective is to develop a sensitive identification and safety assessment of hazardous chemicals.
Fields of science
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding SchemeHORIZON-AG-UN - HORIZON Unit Grant
V8P 5C2 Victoria
See on map