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Novel Methods to Identify Endocrine Disruption Induced Neurotoxicity

Project description

Novel methods to identify neurotoxic chemicals and their mechanism of action

The incidence of neurodevelopmental disorders is increasing among children, and this trend has been linked to man-made chemicals and developmental neurotoxicity (DNT). The current guidelines are insufficient to properly identify chemicals that are toxic to the developing brain. Funded by the Marie Skłodowska-Curie Actions programme, the neurOmics project aims to find new, more sensitive and reliable approaches to evaluate endocrine DNT-induced disruptions. The study will employ molecular methods and omics technologies to test the hypotheses that lipids and myelination represent targets for endocrine-disrupting DNT. High-resolution mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging will provide a more reliable measurement of fluctuating hormone levels. The objective is to develop a sensitive identification and safety assessment of hazardous chemicals.

Coordinator

AARHUS UNIVERSITET
Net EU contribution
€ 277 535,04
Address
Nordre Ringgade 1
8000 Aarhus C
Denmark

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Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Partners (1)

UNIVERSITY OF VICTORIA
Canada
Net EU contribution
No data
Address
Finnerty Road 3800
V8P 5C2 Victoria

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Activity type
Higher or Secondary Education Establishments
Other funding
No data