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Hippocampus unites Memory Systems by preserving Sequential Order

Objective

It is generally assumed that there are two distinct memory systems in the human brain: declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus, historically associated with declarative memory, is also involved in procedural motor memory. Accordingly, the project MemUnited (Hippocampus unites Memory Systems by preserving Sequential Order) proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems. Specifically, given that declarative episodic and procedural motor memories consist of temporally organized sequences of events (e.g. order in which guests arrived at your dinner party) and movements (e.g. playing the piano), and the hippocampus is critical to preserve sequential order of experiences, I will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory. To do so I will use state-of-the-art multivariate pattern analyses of functional Magnetic Resonance Imaging data acquired during the different phases of memory formation (i.e. encoding, consolidation and retrieval). Findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems. The findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular. Moreover, it will open new avenues for the development of integrative treatment of procedural and declarative memory deficits.

Coordinator

UNIVERSITEIT GENT
Net EU contribution
€ 222 003,12
Address
Sint Pietersnieuwstraat 25
9000 Gent
Belgium

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Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
No data

Partners (1)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
United States
Net EU contribution
€ 0,00
Address
Amsterdam Avenue 1210 Room
10027 7003 New York

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution