Descripción del proyecto
Función integradora del hipocampo en los sistemas de memoria
Los dos sistemas de memoria en el encéfalo son la memoria declarativa, que respalda hechos y acontecimientos, y la memoria no declarativa, que respalda habilidades motoras. Diversos estudios recientes sugieren que dichos sistemas de memoria están más interconectados y que el hipocampo participa en ambos. El objetivo del proyecto MemUnited, financiado por las Acciones Marie Skłodowska-Curie, es descubrir el marco integrador de los procesos neuronales comunes en múltiples sistemas de memoria. El proyecto utilizará análisis de patrones multivariados a partir de datos de tomografía por resonancia magnética nuclear funcional en las distintas fases de la formación de la memoria. El objetivo es investigar si los mecanismos de procesamiento de orden secuencial se utilizan en la memoria motora declarativa episódica y no declarativa. Además, el estudio caracterizará la participación del hipocampo en múltiples sistemas de memoria.
Objetivo
It is generally assumed that there are two distinct memory systems in the human brain: declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus, historically associated with declarative memory, is also involved in procedural motor memory. Accordingly, the project MemUnited (Hippocampus unites Memory Systems by preserving Sequential Order) proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems. Specifically, given that declarative episodic and procedural motor memories consist of temporally organized sequences of events (e.g. order in which guests arrived at your dinner party) and movements (e.g. playing the piano), and the hippocampus is critical to preserve sequential order of experiences, I will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory. To do so I will use state-of-the-art multivariate pattern analyses of functional Magnetic Resonance Imaging data acquired during the different phases of memory formation (i.e. encoding, consolidation and retrieval). Findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems. The findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular. Moreover, it will open new avenues for the development of integrative treatment of procedural and declarative memory deficits.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global FellowshipsCoordinador
9000 Gent
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