Description du projet
Le rôle intégrateur de l’hippocampe dans les systèmes de mémoire
Les deux systèmes de mémoire du cerveau comprennent la mémoire déclarative, qui gère les faits et les événements, et la mémoire procédurale, qui gère les facultés motrices. De récentes études laissent entendre que ces systèmes de mémoire sont plus interconnectés qu’on ne le pensait et que l’hippocampe joue un rôle dans les deux. Financé par le programme Actions Marie Skłodowska-Curie, le projet MemUnited entend lever le voile sur le cadre intégratif des processus neuronaux communs à plusieurs systèmes de mémoire. Le projet aura recours à des analyses de modèles multivariés de données provenant d’imagerie par résonance magnétique fonctionnelle pour les différentes phases de la formation de la mémoire. Il vise à découvrir si les mécanismes de traitement de l’ordre séquentiel interviennent dans la mémoire épisodique déclarative et la mémoire motrice procédurale. Qui plus est, l’étude caractérisera le rôle de l’hippocampe dans plusieurs systèmes de mémoire.
Objectif
It is generally assumed that there are two distinct memory systems in the human brain: declarative memory supports memories for facts and events, while the procedural memory supports motor skills. However, recent evidence suggests that these multiple memory systems are less independent than originally thought and that the hippocampus, historically associated with declarative memory, is also involved in procedural motor memory. Accordingly, the project MemUnited (Hippocampus unites Memory Systems by preserving Sequential Order) proposes and tests an integrative framework that specifies the shared neural processes that support learning and memory across multiple memory systems. Specifically, given that declarative episodic and procedural motor memories consist of temporally organized sequences of events (e.g. order in which guests arrived at your dinner party) and movements (e.g. playing the piano), and the hippocampus is critical to preserve sequential order of experiences, I will investigate whether the neural mechanisms of sequential order processing supported by the hippocampus are jointly used in declarative episodic and procedural motor memory. To do so I will use state-of-the-art multivariate pattern analyses of functional Magnetic Resonance Imaging data acquired during the different phases of memory formation (i.e. encoding, consolidation and retrieval). Findings in the proposed research will fill a gap in the field by providing a detailed characterization of the role of the hippocampus in multiple memory systems. The findings will offer the opportunity to reconsider the historical models of memory classification and develop more integrative views of memory organization in general and hippocampal functioning in particular. Moreover, it will open new avenues for the development of integrative treatment of procedural and declarative memory deficits.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global FellowshipsCoordinateur
9000 Gent
Belgique