Project description
New technology for improved bioprinting
Three-dimensional (3D) printing has benefited several industries in recent years, with technologies incorporating it allowing for better-finished products, faster production, better detail, and even safer workplaces. Bioprinting has been utilising 3D printing for many uses including tissue engineering using extrusion bioprinting – a process that allows to produce high fidelity precise complex structures with living tissue properties. Unfortunately, the post-processing requires cultivation in vitro which causes deformation and shrinkage to the tissue with varied and suboptimal results. The EU-funded Print and Grow project aims for a solution. Specifically, the project will develop a novel technology, 3D bioprinting the tissue in a special gel that offers improved structural stability and live monitoring.
Objective
"Three-dimensional (3D) bioprinting holds great promise for tissue engineering, with extrusion bioprinting in suspended hydrogels becoming the leading bioprinting technique in recent years. In this method, living cells are incorporated within bioinks, extruded layer by layer into a granular support material and undergo gelation through diverse cross-linking mechanisms. It offers high fidelity and precise fabrication of complex structures based on the living tissue properties, however the transition of cell mass mixed with the bioink into functional native-like tissue requires post-printing cultivation in vitro. An often-overlooked drawback of 3D bioprinting is the non-uniform shrinkage and deformation of printed constructs during the post-printing tissue maturation period. This leads to highly-variable and unpredictable engineered constructs, posing a challenge for the technology to meet applicative requirements.
We propose to develop a novel technology of ""Print and Grow"", 3D bioprinting into a specially designed microgel aimed to enhance the long-term structural stability of the printed objects by providing structural support and a possibility for live monitoring during tissue maturation. Our preliminary testing of the Print and Grow method demonstrated accurate bioprinting with high tissue viability while preserving the construct shape and size, unlike current state of the art approaches. We aim to optimize the support material properties and develop scalable and reproducible fabrication techniques. We also plan to test the Print and Grow for a wide range of tissue types and adjust the microgel according to specific tissue requirements. Finally, we will study the in vivo transplantation possibility of the tissue generated through the Print and Grow process. The results of our proof of concept project may lead to emergence of universal and user-friendly 3D bioprinting technology for regenerative medicine, drug discovery and cultured meat industry."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC1
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32000 Haifa
Israel
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