Biointelligent Production Sensor to Measure Viral Activity

Project Information

BioProS

Grant agreement ID: 101070120

DOI

10.3030/101070120

EC signature date 23 June 2022

Start date 1 July 2022

End date 30 June 2026

Funded under

• Digital, Industry and Space

Total cost

€ 6 317 693,50

EU contribution

€ 6 317 693,50

Coordinated by

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Other (10)

Bioware I

Bioware for immunoassays available and characterized

Analytical methods

Analytical methods and data points for conventional HSV1 and rAAV quantification methods defined, implemented and tested

Liquid handling

Liquid handling components selected

Bioprinting

Bioprinting and high-resolution 3D printing for biosensors –preliminary study

Bioware II

Bioware for nucleic acid quantification available and tested

SCORE compatibility

SCORE compatibility of 3D prints characterized

GAMP5

Core principles of GAMP5 during development and production essential for later product launch are identified and specified

BSL2

The legal framework (BSL2) for handling and production of the selected HSV1 and rAAV virus strains is established at FHG

Assay protocols

Assay protocols for virus particle concentration and viral infectivity available

Bioware III

Bioware to quantify the active/infectious virus optimized and available

Demonstrators, pilots, prototypes (4)

Optimized reflectometry MTP

optimizing and adapting the prototype from D4.4 to meet upcoming requirements

Prototype for microfluidic platform

Prototype for microfluidic platform for semi-automated injection of virus samples to biosensor

Functional model

Functional model of the platform available and tested

Bioprinting of swelling cages

3D bioprinting of swelling cages in biosensors

Websites, patent fillings, videos etc. (3)

Public midterm seminar
Website

Website designed and established

Internal project communication

Trainings for internal project communication

Documents, reports (8)

Documented Critical design review
Design for sustainability

Concept of “design for sustainability of bio-intelligent products”

Plan for dissemination and exploitation

Plan for dissemination and exploitation including communication activities and updates

Gender equality

Report on implementation of gender equality strategy

Periodic reports
Project Quality Handbook
IP landscape

Report on IP landscape

Agenda and protocols of project meetings

Data sets, microdata, etc (2)

Raw data acquisition

Raw data acquisition implemented and interface to WP5 defined

SCORE read out

SCORE read out optimized for sensor chip

Data Management Plan (1)

Data management plan

Publications

Peer reviewed articles (7)

A novel solution for real-time <i>in-situ</i> cell distribution monitoring in 3D bioprinting via fluorescence imaging

Author(s): Alessandro Margarita, Simone Giovanni Gugliandolo, Silvia Santoni, Davide Moscatelli, Bianca Maria Colosimo
Published in: Biofabrication, Issue 17, 2025, ISSN 1758-5082
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/ADB891

A computational model of cell viability and proliferation of extrusion-based 3D-bioprinted constructs during tissue maturation process

Author(s): Patrizia Gironi, Ludovico Petraro, Silvia Santoni, Luca Dedé, Bianca Maria Colosimo
Published in: International Journal of Bioprinting, 2023, ISSN 2424-8002
Publisher: Whioce
DOI: 10.18063/ijb.741

In-situ monitoring of defects in extrusion-based bioprinting processes using visible light imaging

Author(s): Simone Giovanni Gugliandolo, Alessandro Margarita, Silvia Santoni, Davide Moscatelli, Bianca Maria Colosimo
Published in: Procedia CIRP, Issue 110, 2023, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/J.PROCIR.2022.06.040

Preliminary tests on PEG-based thermoresponsive polymers for the production of 3D bioprinted constructs

Author(s): Silvia Santoni, Mattia Sponchioni, Simone Giovanni Gugliandolo, Bianca Maria Colosimo, Davide Moscatelli
Published in: Procedia CIRP, Issue 110, 2023, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/J.PROCIR.2022.06.062

In-situ Printability Maps (IPM): A new approach for in-situ printability assessment with application to extrusion-based bioprinting

Author(s): Giovanni Zanderigo, Filippo Bracco, Quirico Semeraro, Bianca Maria Colosimo
Published in: Bioprinting, 2023, ISSN 2405-8866
Publisher: Elsevier
DOI: 10.1016/j.bprint.2023.e00320

Towards a sustainability-oriented development of biointelligent products

Author(s): Surya Mächtlen, Yannick Baumgarten, Alexandra Müller, Jörg Woidasky, Robert Miehe
Published in: Procedia CIRP, Issue 125, 2025, ISSN 2212-8271
Publisher: Elsevier BV
DOI: 10.1016/J.PROCIR.2024.08.035

A new solution for in situ monitoring of shape fidelity in extrusion-based bioprinting via thermal imaging

Author(s): Simone Giovanni Gugliandolo, Egon Prioglio, Davide Moscatelli, Bianca Maria Colosimo
Published in: International Journal of Bioprinting, 2024, ISSN 2424-7723
Publisher: AccScience Publishing
DOI: 10.36922/IJB.2021

Book chapters (1)

Ordinal Discriminative Dimensionality Reduction of Functional Profiles

Author(s): Giulia Patanè, Federica Nicolussi, Alexander Krauth, Günter Gauglitz, Bianca Maria Colosimo, Luca Dede’, Alessandra Menafoglio
Published in: Italian Statistical Society Series on Advances in Statistics, Methodological and Applied Statistics and Demography IV, 2025
Publisher: Springer Nature Switzerland
DOI: 10.1007/978-3-031-64447-4_68