Biointelligent Production Sensor to Measure Viral Activity

Información del proyecto

BioProS

Identificador del acuerdo de subvención: 101070120

DOI

10.3030/101070120

Fecha de la firma de la CE 23 Junio 2022

Fecha de inicio 1 Julio 2022

Fecha de finalización 30 Junio 2026

Financiado con arreglo a

• Digital, Industry and Space

Coste total

€ 6 317 693,50

Aportación de la UE

€ 6 317 693,50

Coordinado por

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Other (10)

Bioware I

Bioware for immunoassays available and characterized

Analytical methods

Analytical methods and data points for conventional HSV1 and rAAV quantification methods defined, implemented and tested

Liquid handling

Liquid handling components selected

Bioprinting

Bioprinting and high-resolution 3D printing for biosensors –preliminary study

Bioware II

Bioware for nucleic acid quantification available and tested

SCORE compatibility

SCORE compatibility of 3D prints characterized

GAMP5

Core principles of GAMP5 during development and production essential for later product launch are identified and specified

BSL2

The legal framework (BSL2) for handling and production of the selected HSV1 and rAAV virus strains is established at FHG

Assay protocols

Assay protocols for virus particle concentration and viral infectivity available

Bioware III

Bioware to quantify the active/infectious virus optimized and available

Demonstrators, pilots, prototypes (4)

Optimized reflectometry MTP

optimizing and adapting the prototype from D4.4 to meet upcoming requirements

Prototype for microfluidic platform

Prototype for microfluidic platform for semi-automated injection of virus samples to biosensor

Functional model

Functional model of the platform available and tested

Bioprinting of swelling cages

3D bioprinting of swelling cages in biosensors

Websites, patent fillings, videos etc. (3)

Public midterm seminar
Website

Website designed and established

Internal project communication

Trainings for internal project communication

Documents, reports (8)

Documented Critical design review
Design for sustainability

Concept of “design for sustainability of bio-intelligent products”

Plan for dissemination and exploitation

Plan for dissemination and exploitation including communication activities and updates

Gender equality

Report on implementation of gender equality strategy

Periodic reports
Project Quality Handbook
IP landscape

Report on IP landscape

Agenda and protocols of project meetings

Data sets, microdata, etc (2)

Raw data acquisition

Raw data acquisition implemented and interface to WP5 defined

SCORE read out

SCORE read out optimized for sensor chip

Data Management Plan (1)

Data management plan

Publicaciones

Peer reviewed articles (7)

A novel solution for real-time <i>in-situ</i> cell distribution monitoring in 3D bioprinting via fluorescence imaging

Autores: Alessandro Margarita, Simone Giovanni Gugliandolo, Silvia Santoni, Davide Moscatelli, Bianca Maria Colosimo
Publicado en: Biofabrication, Edición 17, 2025, ISSN 1758-5082
Editor: IOP Publishing
DOI: 10.1088/1758-5090/ADB891

A computational model of cell viability and proliferation of extrusion-based 3D-bioprinted constructs during tissue maturation process

Autores: Patrizia Gironi, Ludovico Petraro, Silvia Santoni, Luca Dedé, Bianca Maria Colosimo
Publicado en: International Journal of Bioprinting, 2023, ISSN 2424-8002
Editor: Whioce
DOI: 10.18063/ijb.741

In-situ monitoring of defects in extrusion-based bioprinting processes using visible light imaging

Autores: Simone Giovanni Gugliandolo, Alessandro Margarita, Silvia Santoni, Davide Moscatelli, Bianca Maria Colosimo
Publicado en: Procedia CIRP, Edición 110, 2023, ISSN 2212-8271
Editor: Elsevier BV
DOI: 10.1016/J.PROCIR.2022.06.040

Preliminary tests on PEG-based thermoresponsive polymers for the production of 3D bioprinted constructs

Autores: Silvia Santoni, Mattia Sponchioni, Simone Giovanni Gugliandolo, Bianca Maria Colosimo, Davide Moscatelli
Publicado en: Procedia CIRP, Edición 110, 2023, ISSN 2212-8271
Editor: Elsevier BV
DOI: 10.1016/J.PROCIR.2022.06.062

In-situ Printability Maps (IPM): A new approach for in-situ printability assessment with application to extrusion-based bioprinting

Autores: Giovanni Zanderigo, Filippo Bracco, Quirico Semeraro, Bianca Maria Colosimo
Publicado en: Bioprinting, 2023, ISSN 2405-8866
Editor: Elsevier
DOI: 10.1016/j.bprint.2023.e00320

Towards a sustainability-oriented development of biointelligent products

Autores: Surya Mächtlen, Yannick Baumgarten, Alexandra Müller, Jörg Woidasky, Robert Miehe
Publicado en: Procedia CIRP, Edición 125, 2025, ISSN 2212-8271
Editor: Elsevier BV
DOI: 10.1016/J.PROCIR.2024.08.035

A new solution for in situ monitoring of shape fidelity in extrusion-based bioprinting via thermal imaging

Autores: Simone Giovanni Gugliandolo, Egon Prioglio, Davide Moscatelli, Bianca Maria Colosimo
Publicado en: International Journal of Bioprinting, 2024, ISSN 2424-7723
Editor: AccScience Publishing
DOI: 10.36922/IJB.2021

Book chapters (1)

Ordinal Discriminative Dimensionality Reduction of Functional Profiles

Autores: Giulia Patanè, Federica Nicolussi, Alexander Krauth, Günter Gauglitz, Bianca Maria Colosimo, Luca Dede’, Alessandra Menafoglio
Publicado en: Italian Statistical Society Series on Advances in Statistics, Methodological and Applied Statistics and Demography IV, 2025
Editor: Springer Nature Switzerland
DOI: 10.1007/978-3-031-64447-4_68