BIOS: The bio-intelligent DBTL cycle, a key enabler catalysing the industrial transformation towards sustainable biomanufacturing

Projektinformationen

BIOS

ID Finanzhilfevereinbarung: 101070281

DOI

10.3030/101070281

EK-Unterschriftsdatum 23 Juni 2022

Startdatum 1 Oktober 2022

Enddatum 30 September 2026

Finanziert unter

• Digital, Industry and Space

Gesamtkosten

€ 6 285 668,25

EU-Beitrag

€ 6 285 167,75

Koordiniert durch

UNIVERSITY OF STUTTGART
Germany

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (15)

Rev. LCA

Report- Overview of LCA basic information

CRISPR-NA

Tool - Non-automated CRISPR protocol

CRISPR-MULTI

Multiplex CRISPRi/a/transposon protocols

AutoSeq

Report - SOPs fully automated transcript seq

Design Review

Report - Critical design review

E-GEM

Model is set

Safe-by-design

Safe-by-design framework

FlexGene

Tool - Flexible gene expression system set

Cellular metabolism

Model is set

Prototype DoE

Protoype of simplified embeddings for autonomous DoE

Process model

Model is set

Open Science I

Stakeholder meeting report I

Transmod

Tool is set: The cellular model allows to predict in vivo elongation rates in P. putida for a marker protein based on the DNA/RNA sequence

ANN models

Machine Learning Software

Transformation

Report - Protocol for cell transformation

Other (9)

Stress tolerance

Identification of factors inducing stress in P. putida producer strains - Analysis of various stress responses in P. putida engineered strains. As a result of serial stress tests with stressors such as terpenoids, methanol, formats, lignin, and methacrylates stress responses are identified and hints for key tuning parameters found.

C1 growth

Other -PHA producers grows on C1 source

Biotransformation

Other - Improved biotransformation from methanol & formate

ALE-optimized strains

Other - Metabolic modules optimized by ALE

Lycopene 0

Other- P. putida lyc0 platform engineered

MD design

Other - Model discriminating design experimentally evaluated

Public Call

Public call for subcontraction launched

Dissemination plan

Dissemination plan set

RL-VAE

Other - Training methods for machine learning

Demonstrators, pilots, prototypes (3)

Transformation platform

Tool -Automated transformation platform

Microfluidic

Tool- First microfluidic system including electrodes, pumps and electroporation generator – a microfluidic system is engineered that allows electroporation of microbes in an automated manner in preliminary tests.

Rapid prototyping

Tool - rapid prototyping basics established

Veröffentlichungen

Peer reviewed articles (7)

Microbial Biotechnology

Autoren: Marco A. Campos‐Magaña; Vitor A. P. Martins dos Santos; Luis Garcia‐Morales
Veröffentlicht in: Microbial Biotechnology, 2025, ISSN 1751-7907
Herausgeber: Wiley
DOI: 10.1111/1751-7915.70104

Paving the way for synthetic C1 - Metabolism in Pseudomonas putida through the reductive glycine pathway

Autoren: Lyon Bruinsma, Sebastian Wenk, Nico J. Claassens,, Vitor A. P. Martins dos Santos
Veröffentlicht in: Metabolic Engineering, 2023, ISSN 1096-7176
Herausgeber: Elsevier
DOI: 10.1016/j.ymben.2023.02.004

Valorising waste in biomanufacturing: Complexities of circularity, safety and sustainability

Autoren: Alexandra Müller, Zoë Robaey, Fathya Hekmatyar, Nikhil Bharadwaj Sairam, Christos Batianis, Enrique Asin-Garcia, Vitor A.P. Martins dos Santos
Veröffentlicht in: Journal of Cleaner Production, Ausgabe 528, 2025, ISSN 0959-6526
Herausgeber: Elsevier BV
DOI: 10.1016/J.JCLEPRO.2025.146685

Trends in Biotechnology

Autoren: Asin-Garcia, Enrique; Fawcett, James D.; Batianis, Christos; Martins dos Santos, Vitor A.P.
Veröffentlicht in: Trends in Biotechnology, 2025, ISSN 0167-7799
Herausgeber: Elsevier BV
DOI: 10.1016/J.TIBTECH.2024.10.014

Metabolic Engineering

Autoren: Batianis, Christos; van Rosmalen, Rik P.; Major, Monika; van Ee, Cheyenne; Kasiotakis, Alexandros; Weusthuis, Ruud A.; Martins dos Santos, Vitor A.P.
Veröffentlicht in: Metabolic Engineering, 2023, ISSN 1096-7176
Herausgeber: Academic Press
DOI: 10.1016/J.YMBEN.2022.10.002

Multilayered safety framework for living diagnostics in the colon

Autoren: Sonia Mecacci; Lucía Torregrosa-Barragán; Enrique Asin-Garcia; Enrique Asin-Garcia; Robert W. Smith
Veröffentlicht in: Frontiers in Systems Biology, 2023, ISSN 2674-0702
Herausgeber: Frontiers Media SA
DOI: 10.3389/FSYSB.2023.1240040

Metabolic Engineering

Autoren: Batianis, Christos; van Rosmalen, Rik P.; Major, Monika; van Ee, Cheyenne; Kasiotakis, Alexandros; Weusthuis, Ruud A.; Martins dos Santos, Vitor A.P.
Veröffentlicht in: Metabolic Engineering, 2023, ISSN 1096-7176
Herausgeber: Academic Press
DOI: 10.1016/j.ymben.2022.10.002