CORDIS - EU research results

Focused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)

Project description

Novel stimulation and recording system for treatment-resistant depression patients

Major depressive disorder (MDD) is a mood disorder which can interfere with daily life, and it is a major contributor to the overall global disease burden. About one third of MDD patients do not respond to established treatments. What is more, reliable biomarkers for depression are needed as a diagnostic tool. The EU-funded UPSIDE project aims to address these issues. To that end, it will research and validate in vivo a hybrid neurotechnology consisting of an epidural focused ultrasound stimulator and a high-density epidural EEG recording system. Project work will lead to a demonstrator, paving the way for personalised treatments for treatment-resistant depression patients.


Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients. Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation, deep brain stimulation (DBS) and transcranial focused ultrasound (tFUS) still show poor spatial resolution (ECT, tRMS, tFUS) or low network coverage (VNS, DBS), with average remission rates in clinical trials still lower than 30 %. Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool, and, in the case of NT, to determine the stimulation efficacy and allow for personalized treatment. The UPSIDE project proposes a minimally invasive, high spatial resolution and multi-brain region stimulation and recording system to largely exceed the capabilities of existing NT for depression. Our objective is to research and validate in vivo an hybrid neurotechnology consisting of an epidural focused ultrasound (eFUS) stimulator employing three-dimensional beamforming, and a high-density epidural EEG recording system. Epidural deployment of these devices will be enabled by novel methods for massive integration and miniaturization of high-performing piezoelectric ultrasound materials and high-fidelity organic bioelectronic materials with high energy-efficient complementary metal-oxide semiconductor (CMOS) technology in a biocompatible manner. The UPSIDE project will result in a demonstrator which will allow, for the first time, network stimulation and simultaneous biomarker readout in behavioral experiments with animal models featuring depression-like symptoms. This technological breakthrough will pave the way towards a personalized treatment for TRD.


Net EU contribution
€ 1 678 031,00
2628 CN Delft

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West-Nederland Zuid-Holland Delft en Westland
Activity type
Higher or Secondary Education Establishments
Total cost
€ 1 678 031,25

Participants (4)

Partners (2)