Project description DEENESFRITPL Novel stimulation and recording system for treatment-resistant depression patients Major depressive disorder (MDD) is a mood disorder which can interfere with daily life, and it is a major contributor to the overall global disease burden. About one third of MDD patients do not respond to established treatments. What is more, reliable biomarkers for depression are needed as a diagnostic tool. The EU-funded UPSIDE project aims to address these issues. To that end, it will research and validate in vivo a hybrid neurotechnology consisting of an epidural focused ultrasound stimulator and a high-density epidural EEG recording system. Project work will lead to a demonstrator, paving the way for personalised treatments for treatment-resistant depression patients. Show the project objective Hide the project objective Objective Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting 300 million people with a lifetime prevalence of 15%. Approximately one third of all MDD patients fail to respond to currently established treatments based on medication and psychotherapy, thus falling into the category of Treatment-Resistant Depression (TRD) patients. Electroconvulsive therapy (ECT), repetitive Transcranial Magnetic Stimulation (tRMS), Vagus nerve stimulation, deep brain stimulation (DBS) and transcranial focused ultrasound (tFUS) still show poor spatial resolution (ECT, tRMS, tFUS) or low network coverage (VNS, DBS), with average remission rates in clinical trials still lower than 30 %. Apart from the existing stimulation hurdles, reliable biomarkers for depression are needed as a diagnostic tool, and, in the case of NT, to determine the stimulation efficacy and allow for personalized treatment. The UPSIDE project proposes a minimally invasive, high spatial resolution and multi-brain region stimulation and recording system to largely exceed the capabilities of existing NT for depression. Our objective is to research and validate in vivo an hybrid neurotechnology consisting of an epidural focused ultrasound (eFUS) stimulator employing three-dimensional beamforming, and a high-density epidural EEG recording system. Epidural deployment of these devices will be enabled by novel methods for massive integration and miniaturization of high-performing piezoelectric ultrasound materials and high-fidelity organic bioelectronic materials with high energy-efficient complementary metal-oxide semiconductor (CMOS) technology in a biocompatible manner. The UPSIDE project will result in a demonstrator which will allow, for the first time, network stimulation and simultaneous biomarker readout in behavioral experiments with animal models featuring depression-like symptoms. This technological breakthrough will pave the way towards a personalized treatment for TRD. Fields of science social sciencespsychologypsychotherapymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesphysical scienceselectromagnetism and electronicssemiconductivitynatural sciencesphysical sciencesacousticsultrasound Keywords Ultrasound neuromodulation neuronal recording closed-loop stimulation treatment resistant depression Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2021-PATHFINDERCHALLENGES-01-02 - Tools to measure and stimulate activity in Brain Tissue Call for proposal HORIZON-EIC-2021-PATHFINDERCHALLENGES-01 See other projects for this call Funding Scheme HORIZON-EIC - HORIZON EIC Grants Coordinator TECHNISCHE UNIVERSITEIT DELFT Net EU contribution € 1 678 031,00 Address STEVINWEG 1 2628 CN Delft Netherlands See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 678 031,25 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITEIT GENT Belgium Net EU contribution € 859 040,00 Address SINT PIETERSNIEUWSTRAAT 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 859 040,00 UNIVERSITAETSKLINIKUM FREIBURG Germany Net EU contribution € 523 150,00 Address HUGSTETTER STRASSE 49 79106 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 523 150,00 NEWRONIKA SPA Italy Net EU contribution € 436 750,00 Address FORO BUONAPARTE 57 20121 Milano See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 436 750,00 SILICONGATE LDA Portugal Net EU contribution € 652 950,00 Address RUA ALFREDO ALLEN 455-461 4200-255 Porto See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Norte Área Metropolitana do Porto Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 652 950,00 Partners (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Micro Systems Technologies Management GmbH Germany Net EU contribution € 0,00 Address Sieversufer 7-9 12359 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data FOCUSED ULTRASOUND FOUNDATION United States Net EU contribution € 0,00 Address CEDARS COURT 22903 Charlottesville See on map Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
