Focused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)

Información del proyecto

UPSIDE

Identificador del acuerdo de subvención: 101070931

DOI

10.3030/101070931

Fecha de la firma de la CE 23 Junio 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 4 149 921,25

Aportación de la UE

€ 4 149 921,00

Coordinado por

TECHNISCHE UNIVERSITEIT DELFT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (9)

CMOS recording interface with ~64 channels for EEG recording and passive MEAs

This report will include electrical characterization results of a CMOS interface demonstrator, including graphs showing power consumption, noise performance, and transfer function of the recording channels. The report will include characterizations with and without the passive MEA, as well as a description of the MEA/CMOS interconnect.

In vivo LFP detection with conformable passive MEA (>1500 electrodes/cm2)

This report will present photos and characterization graphs (e.g. electrochemical impedance) of the passive microelectrode arrays, as well as time-frequency spectrograms of LFP recordings from a cortical surface with designated behavioural states, high-pass filtered traces of waveforms, trigger averaging of waveforms demonstrating consistent action potential morphology, and autocorrelograms indicative of neural firing refractory periods.

eFUS chip: Biological/histological evidence of efficacy

The report will include the first in vivo results using the eFUS chip manufactured by the consortium. The eFUS chip will be implanted and the animals will recover, and will be stimulated over 5 days according to pre-determined parameters. Histological methods will describe the biological effects of the eFUS (e.g. c-fos, TUNNEL, inflammation markers, etc). Molecular methods will describe regional changes in gene expression in key areas (mPFC, NAc).

Project Handbook

This deliverable will consist of a guide to implementation the UPSIDE project It includes a detailed project management plan including the Gantt chart and the Work Package structure the schedule per task responsible partner for the related subtasks the related deliverables and the dependencies on other tasks The handbook should act as a a reference source for all consortium members covering many daytoday activities

Report on the integration of CMOS 64-channel recording interface with passive MEA (eREC64)

This report will include results of electrical characterization of the CMOS 64-channel recording interface with assembled and interconnected passive MEAs, including: (i) time-domain graphs with the recorded data resulting from stimulation a saline solution with a passive tungsten electrode. (ii) noise plots obtained with a spectrum analyzer will also be reported here, with annotations representing the fully integrated noise in the bandwidth of interest. (iii) transfer-function frequency plot obtained from a network analyzer.

in vivo targeting of FUS stimulation: safety and precision

The report will include the results of in vivo acute studies using commercially available FUS in anaesthetized rats. The data described will concern the safety aspects, and the refinement of the “targeting”. Biological effects of the stimulation will be confirmed during the surgical session using electrophysiological methods, and post-mortem by using histological methods. Regions of interest examined will include mPFC, and NAc, for example.

Plan for dissemination, communication and exploitation

This plan describes the strategy procedures and tool for dissemination communication and exploitation of project results and also focuses on the public engagement

Report on chronic detection of EEG signals for biomarker detection algorithms, in an in vivo animal model with IGT-array for >3 weeks

This report will show photos of IGT-based devices, placement procedure, and EEG data acquired by an IGT array over > 3 weeks period of time. Time-frequency spectrograms of the recordings, high filtered traces of waveforms will be shown indicating potential biomarkers. Spectrograms and raw data will be analysed to understand best methods to extract depression biomarkers.

eFUS chip implantation protocol and preliminary FUS stimulation parameters

The report will include the results of our initial in vivo and ex vivo studies using phantom agar and post-mortem fixed and unfixed brains. These preliminary studies will use commercially available FUS. The report will include protocols and parameters concerning the intensity and targeting of the stimulation which will be transferred over to the device emerging from the other WPs. The report will also describe craniotomy and protocols to implant “dummy” eFUS and eREC chips.

Websites, patent fillings, videos etc. (1)

Internal and public website (regularly updated)

Internal project coordination tool public internet website and other social media channels to communicate and disseminate the project results

Data Management Plan (2)

Data management plan - V1

This plan will describe what data the project will identify and generate how to handle with it and how the FAIR principles will be implemented

R2 updates on the DMP

First update of the Data Management Plan (DMP)

Demonstrators, pilots, prototypes (2)

Prototype of relay station

This report will present electrical characterization results of the manufactured demonstrator of the relay station. This will include time-domain graphs with the input and output signals of a microcontroller used to program and acquired data from the eREC and eFUS devices, graphs with the characterization of the power unit in the relay station and demonstration of wireless connectivity with a computer by sending and receiving programming commands.

Conformable IGT-array (>1500 interfaces/cm2) with superior SNR (>20 dB increase) and >1 month in vitro stability

This report will present photos and characterization graphs (e.g. IVgraphs, temporal response, frequency response) of the IGT array. In addition, we will show comparable acquired electrophysiological signals from IGT and passive arrays with SNR increase. In-vitro stability will be shown with prolonged operation (drain current modulation for pulsed gate voltage) in physiologic conditions.

Publicaciones

Peer reviewed articles (9)

Chronic in vivo sequelae of repetitive acute mfb‐<scp>DBS</scp> on accumbal dopamine and midbrain neuronal activity

Autores: Lidia Miguel Telega, Danesh Ashouri Vajari, Chockalingam Ramanathan, Volker A. Coenen, Máté D. Döbrössy
Publicado en: Journal of Neurochemistry, Edición 169, 2025, ISSN 0022-3042
Editor: Wiley
DOI: 10.1111/JNC.16223

Hybrid neuroelectronics: towards a solution-centric way of thinking about complexproblems in neurostimulation tools

Autores: Sofia Drakopoulou; Francesc Varkevisser; Linta Sohail; Masoumeh Aqamolaei; Tiago L. Costa; George D. Spyropoulos
Publicado en: Frontiers in Electronics, 2023, ISSN 2673-5857
Editor: Frontiers
DOI: 10.3389/felec.2023.1250655

LIFU for major depressive disorder – Targeting the neural networks of depression

Autores: Tiago Costa
Publicado en: openaccessgovernment.org, 2023, ISSN 2516-3817
Editor: openaccessgovernment
DOI: 10.56367/OAG-039-10653

Acute and chronic gene expression activation following medial forebrain bundle DBS and selective dopamine pathway stimulation

Autores: Zhuo Duan, Wen Zhao, Yixin Tong, Volker A. Coenen, Máté D. Döbrössy
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-91994-X

Reserpine-induced rat model for depression: Behavioral, physiological and PET-based dopamine receptor availability validation

Autores: Lidia Miguel Telega, Raissa Berti, Ganna Blazhenets, Lisa-Charlotte Domogalla, Nils Steinacker, M. Aymen Omrane, Philipp T. Meyer, Volker A. Coenen, Ann-Christin Eder, Máté D. Döbrössy
Publicado en: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Edición 133, 2024, ISSN 0278-5846
Editor: Elsevier BV
DOI: 10.1016/J.PNPBP.2024.111013

Neuronal networks of depression: Pushing the limits of brain stimulation technology

Autores: Tiago Costa, Volker Arnd Coenen, Máté Dániel Döbrössy
Publicado en: openaccessgovernment.org, 2023, ISSN 2516-3817
Editor: openaccessgovernment.org
DOI: 10.56367/OAG-038-10653

Major depressive disorder: Brain signals as biomarkers for depression

Autores: Tiago Costa
Publicado en: openaccessgovernment.org, 2023, ISSN 2516-3817
Editor: openaccessgovernment.org
DOI: 10.56367/OAG-040-10653

Low-Intensity Focused Ultrasound (LIFU) is an emerging neuromodulation method for treating major depressive disorder which allows for non-invasive stimulation across the whole brain

Autores: Tiago Costa
Publicado en: openaccessgovernment.org, 2022, ISSN 2516-3817
Editor: openaccessgovernment
DOI: 10.56367/OAG-037-10597

PMUT and CMUT Devices for Biomedical Applications: A Review

Autores: Elisabetta Moisello, Lara Novaresi, Eshani Sarkar, Piero Malcovati, Tiago L. Costa, Edoardo Bonizzoni
Publicado en: IEEE Access, Edición 12, 2024, ISSN 2169-3536
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/ACCESS.2024.3359906

Conference proceedings (5)

2D Phased Array Driving Scheme Optimization for Ultrasound Neuromodulation

Autores: Masoumeh Aqamolaei, Tiago L. Costa
Publicado en: 2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS), 2024
Editor: IEEE
DOI: 10.1109/UFFC-JS60046.2024.10793494

An Acoustically Transparent Electrical Cap for Piezoelectric Ultrasound Transducers on Silicon

Autores: Gandhika K. Wardhana, Tiago L. Costa, Massimo Mastrangeli
Publicado en: Eurosensors 2023, 2024
Editor: MDPI
DOI: 10.3390/proceedings2024097050

A Power-Efficient Oscillatory Synchronization Feature Extractor for Closed-Loop Neuromodulation

Autores: Hoda Yassin, Arash Akhoundi, El-Sayed Hasaneen, Dante G. Muratore
Publicado en: IEEE Transactions on Circuits and Systems II: Express Briefs, Edición 71, 2024, ISSN 1549-7747
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TCSII.2024.3353927

Soft electronics and materials for ear to brain engineering

Autores: George D. Spyropoulos
Publicado en: Proceedings of the MATSUS Fall 2023 Conference, 2023
Editor: FUNDACIO DE LA COMUNITAT VALENCIANA SCITO
DOI: 10.29363/nanoge.matsus.2023.260

A Low-Power Oscillatory Feature Extraction Unit for Implantable Neural Interfaces

Autores: Hoda; Arash; El-Sayed; Dante G.
Publicado en: IEEE International Symposium on Circuits and Systems (ISCAS), 2023
Editor: IIEE
DOI: 10.1109/ISCAS46773.2023.10181914