Focused Ultrasound Personalized Therapy for the Treatment of Depression (UPSIDE)

Informations projet

UPSIDE

N° de convention de subvention: 101070931

DOI

10.3030/101070931

Date de signature de la CE 23 Juin 2022

Date de début 1 Septembre 2022

Date de fin 31 Août 2026

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 4 149 921,25

Contribution de l’UE

€ 4 149 921,00

Coordonné par

TECHNISCHE UNIVERSITEIT DELFT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (9)

CMOS recording interface with ~64 channels for EEG recording and passive MEAs

This report will include electrical characterization results of a CMOS interface demonstrator, including graphs showing power consumption, noise performance, and transfer function of the recording channels. The report will include characterizations with and without the passive MEA, as well as a description of the MEA/CMOS interconnect.

In vivo LFP detection with conformable passive MEA (>1500 electrodes/cm2)

This report will present photos and characterization graphs (e.g. electrochemical impedance) of the passive microelectrode arrays, as well as time-frequency spectrograms of LFP recordings from a cortical surface with designated behavioural states, high-pass filtered traces of waveforms, trigger averaging of waveforms demonstrating consistent action potential morphology, and autocorrelograms indicative of neural firing refractory periods.

eFUS chip: Biological/histological evidence of efficacy

The report will include the first in vivo results using the eFUS chip manufactured by the consortium. The eFUS chip will be implanted and the animals will recover, and will be stimulated over 5 days according to pre-determined parameters. Histological methods will describe the biological effects of the eFUS (e.g. c-fos, TUNNEL, inflammation markers, etc). Molecular methods will describe regional changes in gene expression in key areas (mPFC, NAc).

Project Handbook

This deliverable will consist of a guide to implementation the UPSIDE project It includes a detailed project management plan including the Gantt chart and the Work Package structure the schedule per task responsible partner for the related subtasks the related deliverables and the dependencies on other tasks The handbook should act as a a reference source for all consortium members covering many daytoday activities

Report on the integration of CMOS 64-channel recording interface with passive MEA (eREC64)

This report will include results of electrical characterization of the CMOS 64-channel recording interface with assembled and interconnected passive MEAs, including: (i) time-domain graphs with the recorded data resulting from stimulation a saline solution with a passive tungsten electrode. (ii) noise plots obtained with a spectrum analyzer will also be reported here, with annotations representing the fully integrated noise in the bandwidth of interest. (iii) transfer-function frequency plot obtained from a network analyzer.

in vivo targeting of FUS stimulation: safety and precision

The report will include the results of in vivo acute studies using commercially available FUS in anaesthetized rats. The data described will concern the safety aspects, and the refinement of the “targeting”. Biological effects of the stimulation will be confirmed during the surgical session using electrophysiological methods, and post-mortem by using histological methods. Regions of interest examined will include mPFC, and NAc, for example.

Plan for dissemination, communication and exploitation

This plan describes the strategy procedures and tool for dissemination communication and exploitation of project results and also focuses on the public engagement

Report on chronic detection of EEG signals for biomarker detection algorithms, in an in vivo animal model with IGT-array for >3 weeks

This report will show photos of IGT-based devices, placement procedure, and EEG data acquired by an IGT array over > 3 weeks period of time. Time-frequency spectrograms of the recordings, high filtered traces of waveforms will be shown indicating potential biomarkers. Spectrograms and raw data will be analysed to understand best methods to extract depression biomarkers.

eFUS chip implantation protocol and preliminary FUS stimulation parameters

The report will include the results of our initial in vivo and ex vivo studies using phantom agar and post-mortem fixed and unfixed brains. These preliminary studies will use commercially available FUS. The report will include protocols and parameters concerning the intensity and targeting of the stimulation which will be transferred over to the device emerging from the other WPs. The report will also describe craniotomy and protocols to implant “dummy” eFUS and eREC chips.

Websites, patent fillings, videos etc. (1)

Internal and public website (regularly updated)

Internal project coordination tool public internet website and other social media channels to communicate and disseminate the project results

Data Management Plan (2)

Data management plan - V1

This plan will describe what data the project will identify and generate how to handle with it and how the FAIR principles will be implemented

R2 updates on the DMP

First update of the Data Management Plan (DMP)

Demonstrators, pilots, prototypes (2)

Prototype of relay station

This report will present electrical characterization results of the manufactured demonstrator of the relay station. This will include time-domain graphs with the input and output signals of a microcontroller used to program and acquired data from the eREC and eFUS devices, graphs with the characterization of the power unit in the relay station and demonstration of wireless connectivity with a computer by sending and receiving programming commands.

Conformable IGT-array (>1500 interfaces/cm2) with superior SNR (>20 dB increase) and >1 month in vitro stability

This report will present photos and characterization graphs (e.g. IVgraphs, temporal response, frequency response) of the IGT array. In addition, we will show comparable acquired electrophysiological signals from IGT and passive arrays with SNR increase. In-vitro stability will be shown with prolonged operation (drain current modulation for pulsed gate voltage) in physiologic conditions.

Publications

Peer reviewed articles (9)

Chronic in vivo sequelae of repetitive acute mfb‐<scp>DBS</scp> on accumbal dopamine and midbrain neuronal activity

Auteurs: Lidia Miguel Telega, Danesh Ashouri Vajari, Chockalingam Ramanathan, Volker A. Coenen, Máté D. Döbrössy
Publié dans: Journal of Neurochemistry, Numéro 169, 2025, ISSN 0022-3042
Éditeur: Wiley
DOI: 10.1111/JNC.16223

Hybrid neuroelectronics: towards a solution-centric way of thinking about complexproblems in neurostimulation tools

Auteurs: Sofia Drakopoulou; Francesc Varkevisser; Linta Sohail; Masoumeh Aqamolaei; Tiago L. Costa; George D. Spyropoulos
Publié dans: Frontiers in Electronics, 2023, ISSN 2673-5857
Éditeur: Frontiers
DOI: 10.3389/felec.2023.1250655

LIFU for major depressive disorder – Targeting the neural networks of depression

Auteurs: Tiago Costa
Publié dans: openaccessgovernment.org, 2023, ISSN 2516-3817
Éditeur: openaccessgovernment
DOI: 10.56367/OAG-039-10653

Acute and chronic gene expression activation following medial forebrain bundle DBS and selective dopamine pathway stimulation

Auteurs: Zhuo Duan, Wen Zhao, Yixin Tong, Volker A. Coenen, Máté D. Döbrössy
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-91994-X

Reserpine-induced rat model for depression: Behavioral, physiological and PET-based dopamine receptor availability validation

Auteurs: Lidia Miguel Telega, Raissa Berti, Ganna Blazhenets, Lisa-Charlotte Domogalla, Nils Steinacker, M. Aymen Omrane, Philipp T. Meyer, Volker A. Coenen, Ann-Christin Eder, Máté D. Döbrössy
Publié dans: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Numéro 133, 2024, ISSN 0278-5846
Éditeur: Elsevier BV
DOI: 10.1016/J.PNPBP.2024.111013

Neuronal networks of depression: Pushing the limits of brain stimulation technology

Auteurs: Tiago Costa, Volker Arnd Coenen, Máté Dániel Döbrössy
Publié dans: openaccessgovernment.org, 2023, ISSN 2516-3817
Éditeur: openaccessgovernment.org
DOI: 10.56367/OAG-038-10653

Major depressive disorder: Brain signals as biomarkers for depression

Auteurs: Tiago Costa
Publié dans: openaccessgovernment.org, 2023, ISSN 2516-3817
Éditeur: openaccessgovernment.org
DOI: 10.56367/OAG-040-10653

Low-Intensity Focused Ultrasound (LIFU) is an emerging neuromodulation method for treating major depressive disorder which allows for non-invasive stimulation across the whole brain

Auteurs: Tiago Costa
Publié dans: openaccessgovernment.org, 2022, ISSN 2516-3817
Éditeur: openaccessgovernment
DOI: 10.56367/OAG-037-10597

PMUT and CMUT Devices for Biomedical Applications: A Review

Auteurs: Elisabetta Moisello, Lara Novaresi, Eshani Sarkar, Piero Malcovati, Tiago L. Costa, Edoardo Bonizzoni
Publié dans: IEEE Access, Numéro 12, 2024, ISSN 2169-3536
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/ACCESS.2024.3359906

Conference proceedings (5)

2D Phased Array Driving Scheme Optimization for Ultrasound Neuromodulation

Auteurs: Masoumeh Aqamolaei, Tiago L. Costa
Publié dans: 2024 IEEE Ultrasonics, Ferroelectrics, and Frequency Control Joint Symposium (UFFC-JS), 2024
Éditeur: IEEE
DOI: 10.1109/UFFC-JS60046.2024.10793494

An Acoustically Transparent Electrical Cap for Piezoelectric Ultrasound Transducers on Silicon

Auteurs: Gandhika K. Wardhana, Tiago L. Costa, Massimo Mastrangeli
Publié dans: Eurosensors 2023, 2024
Éditeur: MDPI
DOI: 10.3390/proceedings2024097050

A Power-Efficient Oscillatory Synchronization Feature Extractor for Closed-Loop Neuromodulation

Auteurs: Hoda Yassin, Arash Akhoundi, El-Sayed Hasaneen, Dante G. Muratore
Publié dans: IEEE Transactions on Circuits and Systems II: Express Briefs, Numéro 71, 2024, ISSN 1549-7747
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TCSII.2024.3353927

Soft electronics and materials for ear to brain engineering

Auteurs: George D. Spyropoulos
Publié dans: Proceedings of the MATSUS Fall 2023 Conference, 2023
Éditeur: FUNDACIO DE LA COMUNITAT VALENCIANA SCITO
DOI: 10.29363/nanoge.matsus.2023.260

A Low-Power Oscillatory Feature Extraction Unit for Implantable Neural Interfaces

Auteurs: Hoda; Arash; El-Sayed; Dante G.
Publié dans: IEEE International Symposium on Circuits and Systems (ISCAS), 2023
Éditeur: IIEE
DOI: 10.1109/ISCAS46773.2023.10181914