Engineering a living human Mini-heart and a swimming Bio-robot

Informations projet

BioRobot-MiniHeart

N° de convention de subvention: 101070953

DOI

10.3030/101070953

Date de signature de la CE 23 Juin 2022

Date de début 1 Novembre 2022

Date de fin 31 Octobre 2027

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 4 475 946,00

Contribution de l’UE

€ 4 475 946,00

Coordonné par

UNIVERSITEIT TWENTE
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (9)

Portfolio’s Dissemination and communication activities RP1

The report includes a description of the activities, the outcomes and any planned follow up.

ELSA activities in RP2

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicablewith the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Contribution to the regulatory debate in RP1

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report.

Plan for Dissemination and exploitation including communication activities

Deliver a dissemination and exploitation plan including communication activities.

Contribution to the regulatory debate in RP2

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report.

Strategic definition of the cell types needed

Based on developmental biology knowhow research we will define the cardiac cell subtypes necessary to better mimic the tissue biology of the human heart.

ELSA activities in RP1.

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicable with the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Portfolio’s Dissemination and communication activities RP2

The report includes a description of the activities, the outcomes and any planned follow up.

Optimized protocol for upscaling differentiation of cardiac ventricular and atrial cardiomyocytes

To produce the ELMs we will need millions of cardiac cells, therfore we will optimized protocol for upscaling differentiation of cardiac ventricular and atrial cardiomyocytes in order to have a constant inflow of cells for the project.

Websites, patent fillings, videos etc. (1)

Logo and website

Having a run website with the address of the title of the project and .eu domain. Having the logo of the project on the website

Data Management Plan (1)

Data Management Plan

Delivery of data management plan

Publications

Peer reviewed articles (4)

Mini-hearts for disease modeling and drug testing – process optimization versus biological functionality

Auteurs: Jana Hecking, Mariel Cano-Jorge, Robert Passier, José Manuel Rivera-Arbeláez
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 13, 2026, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/FBIOE.2025.1719533

Revealing the complexity of the epicardial secretome

Auteurs: Cláudia C. Oliveira, José Córdoba, John R. Pearson, Elizabeth Guruceaga, Ernesto Marín-Sedeño, María López-Moreno, Juan Antonio Guadix, Melissa García-Caballero, José M. Pérez-Pomares, Adrián Ruiz-Villalba
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-24980-Y

Advanced Materials

Auteurs: Alexis Wolfel, Castro Johnbosco, Annalise Anspach, Marieke Meteling, Jos Olijve, Niklas Felix König, Jeroen Leijten
Publié dans: Advanced Materials, ISSN 0935-9648
Éditeur: Wiley
DOI: 10.1002/ADMA.202501052

A human engineered mini-heart platform for mimicking ventricular pump function.

Auteurs: Ribeiro MC, Cano-Jorge M, Ten Den S, Snippert D, Karperien M, Kamperman T, Lajoinie G, Versluis M, Passier R
Publié dans: Cardiovasc Res., 2026, ISSN 1755-3245
Éditeur: Oxford Academic
DOI: 10.1093/CVR/CVAG210