Engineering a living human Mini-heart and a swimming Bio-robot

Informazioni relative al progetto

BioRobot-MiniHeart

ID dell’accordo di sovvenzione: 101070953

DOI

10.3030/101070953

Data della firma CE 23 Giugno 2022

Data di avvio 1 Novembre 2022

Data di completamento 31 Ottobre 2027

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 4 475 946,00

Contributo UE

€ 4 475 946,00

Coordinato da

UNIVERSITEIT TWENTE
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (9)

Portfolio’s Dissemination and communication activities RP1

The report includes a description of the activities, the outcomes and any planned follow up.

ELSA activities in RP2

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicablewith the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Contribution to the regulatory debate in RP1

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report.

Plan for Dissemination and exploitation including communication activities

Deliver a dissemination and exploitation plan including communication activities.

Contribution to the regulatory debate in RP2

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report.

Strategic definition of the cell types needed

Based on developmental biology knowhow research we will define the cardiac cell subtypes necessary to better mimic the tissue biology of the human heart.

ELSA activities in RP1.

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicable with the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Portfolio’s Dissemination and communication activities RP2

The report includes a description of the activities, the outcomes and any planned follow up.

Optimized protocol for upscaling differentiation of cardiac ventricular and atrial cardiomyocytes

To produce the ELMs we will need millions of cardiac cells, therfore we will optimized protocol for upscaling differentiation of cardiac ventricular and atrial cardiomyocytes in order to have a constant inflow of cells for the project.

Websites, patent fillings, videos etc. (1)

Logo and website

Having a run website with the address of the title of the project and .eu domain. Having the logo of the project on the website

Data Management Plan (1)

Data Management Plan

Delivery of data management plan

Pubblicazioni

Peer reviewed articles (4)

Mini-hearts for disease modeling and drug testing – process optimization versus biological functionality

Autori: Jana Hecking, Mariel Cano-Jorge, Robert Passier, José Manuel Rivera-Arbeláez
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 13, 2026, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/FBIOE.2025.1719533

Revealing the complexity of the epicardial secretome

Autori: Cláudia C. Oliveira, José Córdoba, John R. Pearson, Elizabeth Guruceaga, Ernesto Marín-Sedeño, María López-Moreno, Juan Antonio Guadix, Melissa García-Caballero, José M. Pérez-Pomares, Adrián Ruiz-Villalba
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-24980-Y

Advanced Materials

Autori: Alexis Wolfel, Castro Johnbosco, Annalise Anspach, Marieke Meteling, Jos Olijve, Niklas Felix König, Jeroen Leijten
Pubblicato in: Advanced Materials, ISSN 0935-9648
Editore: Wiley
DOI: 10.1002/ADMA.202501052

A human engineered mini-heart platform for mimicking ventricular pump function.

Autori: Ribeiro MC, Cano-Jorge M, Ten Den S, Snippert D, Karperien M, Kamperman T, Lajoinie G, Versluis M, Passier R
Pubblicato in: Cardiovasc Res., 2026, ISSN 1755-3245
Editore: Oxford Academic
DOI: 10.1093/CVR/CVAG210