Engineering a living human Mini-heart and a swimming Bio-robot

Projektinformationen

BioRobot-MiniHeart

ID Finanzhilfevereinbarung: 101070953

DOI

10.3030/101070953

EK-Unterschriftsdatum 23 Juni 2022

Startdatum 1 November 2022

Enddatum 31 Oktober 2027

Finanziert unter

• The European Innovation Council (EIC)

Gesamtkosten

€ 4 475 946,00

EU-Beitrag

€ 4 475 946,00

Koordiniert durch

UNIVERSITEIT TWENTE
Netherlands

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Documents, reports (9)

Portfolio’s Dissemination and communication activities RP1

The report includes a description of the activities, the outcomes and any planned follow up.

ELSA activities in RP2

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicablewith the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Contribution to the regulatory debate in RP1

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report.

Plan for Dissemination and exploitation including communication activities

Deliver a dissemination and exploitation plan including communication activities.

Contribution to the regulatory debate in RP2

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report.

Strategic definition of the cell types needed

Based on developmental biology knowhow research we will define the cardiac cell subtypes necessary to better mimic the tissue biology of the human heart.

ELSA activities in RP1.

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicable with the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Portfolio’s Dissemination and communication activities RP2

The report includes a description of the activities, the outcomes and any planned follow up.

Optimized protocol for upscaling differentiation of cardiac ventricular and atrial cardiomyocytes

To produce the ELMs we will need millions of cardiac cells, therfore we will optimized protocol for upscaling differentiation of cardiac ventricular and atrial cardiomyocytes in order to have a constant inflow of cells for the project.

Websites, patent fillings, videos etc. (1)

Logo and website

Having a run website with the address of the title of the project and .eu domain. Having the logo of the project on the website

Data Management Plan (1)

Data Management Plan

Delivery of data management plan

Veröffentlichungen

Peer reviewed articles (4)

Mini-hearts for disease modeling and drug testing – process optimization versus biological functionality

Autoren: Jana Hecking, Mariel Cano-Jorge, Robert Passier, José Manuel Rivera-Arbeláez
Veröffentlicht in: Frontiers in Bioengineering and Biotechnology, Ausgabe 13, 2026, ISSN 2296-4185
Herausgeber: Frontiers Media SA
DOI: 10.3389/FBIOE.2025.1719533

Revealing the complexity of the epicardial secretome

Autoren: Cláudia C. Oliveira, José Córdoba, John R. Pearson, Elizabeth Guruceaga, Ernesto Marín-Sedeño, María López-Moreno, Juan Antonio Guadix, Melissa García-Caballero, José M. Pérez-Pomares, Adrián Ruiz-Villalba
Veröffentlicht in: Scientific Reports, Ausgabe 15, 2025, ISSN 2045-2322
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-24980-Y

Advanced Materials

Autoren: Alexis Wolfel, Castro Johnbosco, Annalise Anspach, Marieke Meteling, Jos Olijve, Niklas Felix König, Jeroen Leijten
Veröffentlicht in: Advanced Materials, ISSN 0935-9648
Herausgeber: Wiley
DOI: 10.1002/ADMA.202501052

A human engineered mini-heart platform for mimicking ventricular pump function.

Autoren: Ribeiro MC, Cano-Jorge M, Ten Den S, Snippert D, Karperien M, Kamperman T, Lajoinie G, Versluis M, Passier R
Veröffentlicht in: Cardiovasc Res., 2026, ISSN 1755-3245
Herausgeber: Oxford Academic
DOI: 10.1093/CVR/CVAG210