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Closed-loop Individualized image-guided Transcranial Ultrasonic Stimulation

Project description

DEENESFRITPL

Brain ultrasound technique to improve mental and neurological conditions

Ultrasound waves are widely used to image anatomical structures in virtually every part of the body, including the brain. Transcranial ultrasound stimulation (TUS) can noninvasively excite or inhibit neural activity in targeted brain regions. The main roadblock preventing this technique from making a bigger impact in neuroscientific and clinical applications is the difficulty of steering the ultrasound beam onto the intended target and reaching the desired intensity. The EU-funded CITRUS project aims to further develop the potential of TUS to noninvasively modulate deep brain structures with unprecedented spatial precision in the millimetre range. To this end, it targets the development of an integrated TUS-MRI system that will, for the first time, stimulate cortical and subcortical targets in the human brain.

Objective

We are joining forces across Europe to advance a new non-invasive technology – transcranial ultrasound stimulation (TUS) – to reversibly modulate brain regions with exquisite millimetre precision, even deep in the brain. As such, we aim to establish an urgently needed novel treatment option for neurological and psychiatric diseases. TUS combines the precision and reach of invasive deep brain stimulation, required to directly target clinically relevant structures, with the non-invasive and low-cost nature of transcranial electromagnetic techniques that are inherently limited in focus and depth. The main roadblock to widespread adoption of TUS in neuroscientific and clinical applications is the difficulty of steering the small ultrasound focus onto the intended target and reaching the desired intensity, with no empirical validation of targeting success currently available. We will develop a neuronavigated TUS-MRI system with advanced magnetic resonance imaging (MRI)-guided application planning and closed-loop application control to enable safe, individualised, and effective high-precision TUS in humans. As such we will unlock the full potential of TUS to non-invasively modulate deep brain structures with unprecedented spatial precision in the millimetre range. The final prototype will be a fully functional device that integrates novel MR-compatible 256-element TUS-transducers (for advanced 3D-steering of the TUS focus) with a custom-tailored 32-channel MR-receiver coil (for accelerated imaging with maximal sensitivity) and closed-loop target validation using MR-acoustic radiation force imaging (MR-ARFI). This novel device with its unique features will enable for the first time the personalized non-invasive high-precision stimulation of cortical and subcortical targets in the human brain. It will be a game changer for both neuroscientific research and clinical application in neurological and psychiatric diseases with the potential to benefit millions of patients.

Fields of science

Programme(s)

Topic(s)

Call for proposal

HORIZON-EIC-2021-PATHFINDERCHALLENGES-01

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Funding Scheme

HORIZON-AG - HORIZON Action Grant Budget-Based

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Net EU contribution
€ 920 062,50
Address
Spitalgasse 23
1090 Wien
Austria

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Region
Ostösterreich Wien Wien
Activity type
Higher or Secondary Education Establishments
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Other funding
€ 0,00

Participants (6)

Partners (1)

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Last update: 21 September 2022

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Permalink: https://cordis.europa.eu/project/id/101071008

European Union, 2023