Skip to main content

Closed-loop Individualized image-guided Transcranial Ultrasonic Stimulation

Objective

We are joining forces across Europe to advance a new non-invasive technology – transcranial ultrasound stimulation (TUS) – to reversibly modulate brain regions with exquisite millimetre precision, even deep in the brain. As such, we aim to establish an urgently needed novel treatment option for neurological and psychiatric diseases. TUS combines the precision and reach of invasive deep brain stimulation, required to directly target clinically relevant structures, with the non-invasive and low-cost nature of transcranial electromagnetic techniques that are inherently limited in focus and depth. The main roadblock to widespread adoption of TUS in neuroscientific and clinical applications is the difficulty of steering the small ultrasound focus onto the intended target and reaching the desired intensity, with no empirical validation of targeting success currently available. We will develop a neuronavigated TUS-MRI system with advanced magnetic resonance imaging (MRI)-guided application planning and closed-loop application control to enable safe, individualised, and effective high-precision TUS in humans. As such we will unlock the full potential of TUS to non-invasively modulate deep brain structures with unprecedented spatial precision in the millimetre range. The final prototype will be a fully functional device that integrates novel MR-compatible 256-element TUS-transducers (for advanced 3D-steering of the TUS focus) with a custom-tailored 32-channel MR-receiver coil (for accelerated imaging with maximal sensitivity) and closed-loop target validation using MR-acoustic radiation force imaging (MR-ARFI). This novel device with its unique features will enable for the first time the personalized non-invasive high-precision stimulation of cortical and subcortical targets in the human brain. It will be a game changer for both neuroscientific research and clinical application in neurological and psychiatric diseases with the potential to benefit millions of patients.

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Net EU contribution
€ 920 062,50
Address
Spitalgasse 23
1090 Wien
Austria

See on map

Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
€ 920 062,50

Participants (6)

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
Net EU contribution
€ 463 462,50
Address
Langenbeckstrasse 1
55131 Mainz

See on map

Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 463 462,50
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 200 000,00
Address
Kongens Vaenge 2
3400 Hillerod

See on map

Region
Danmark Hovedstaden Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 200 000,00
VYSOKE UCENI TECHNICKE V BRNE
Czechia
Net EU contribution
€ 290 000,00
Address
Antoninska 548/1
601 90 Brno Stred

See on map

Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Other funding
€ 290 000,00
LOCALITE GMBH
Germany
Net EU contribution
€ 125 600,00
Address
Auguststrasse 1
53229 Bonn

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 125 600,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 1 100 277,50
Address
Hansastrasse 27c
80686 Munchen

See on map

Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 1 100 277,50
STICHTING RADBOUD UNIVERSITEIT
Netherlands
Net EU contribution
€ 700 000,00
Address
Houtlaan 4
6525 XZ Nijmegen

See on map

Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Other funding
€ 700 000,00

Partners (1)

UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 0,00
Address
Gower Street
WC1E 6BT London

See on map

Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
No data