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Supervised morphogenesis in gastruloids

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Update preprint with results Objective 1.2. + data repository imaging (figshare) & single-cell (GEO) data; submission for publication (opens in new window)

Successful identification of putative, targetable drivers of variation that can be precisely tuned to minimise variation (Task 1.2). Successful integration of molecular and phenotypic fingerprints. Update preprint with the results of Task 1.2. + data repository imaging (figshare) & single-cell (GEO) data; submission for publication. Link to updated preprint + data repository on SUMO website.

Community resource released as preprint + data repository (figshare) with results Objective 1.1. (opens in new window)

Catalogue of gastruloid morphotypes across the [genetic background x culture condition matrix] with a focus on heart and gut tube formation efficiency & morphodynamics. Community resource released as preprint + data repository (figshare) with results Objective 1.1. Links to community resources on SUMO website.

ELSA activities in RP1 (opens in new window)

Report on the activities outcomes and planned follow up to address ethical legal and social aspects ELSA These activities include engagement with strategic partners including the public and dissemination of best practices and guidelines when applicable with the ELMs field Any confidential information related to these activities will be included in the technical periodic report

Website and project logo (opens in new window)

Launch of SUMO website including project logo Including links to already available projectrelated data protocols computational frameworks Launch of the website will be coordinated with a press release via partner institutes and further promotion via social media of project partners Twitter Facebook ResearchGate LinkedIn

Contribution to the regulatory debate in RP1. (opens in new window)

Report on the activities outcomes and planned follow up to assess and address the ELMs portfolio needs This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies Any confidential information related to these activities will be included in the technical periodic report

Portfolio’s Dissemination and communication activities RP1 (opens in new window)

Report in the form of a presentation andor written text which includes a description of the conducted activities their outcomes and planned followup events Prepared in collaboration with the Media Services and Outreach Facility of the MPICBG Dresden MPG The report will be shared on the SUMO Website

Contribution to the regulatory debate in RP2 (opens in new window)

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report

Portfolio’s Dissemination and communication activities RP2 (opens in new window)

Report in the form of a presentation and/or written text, which includes a description of the conducted activities, their outcomes and planned follow-up events. Prepared in collaboration with the Media Services and Outreach Facility of the MPI-CBG (Dresden, MPG). The report will be shared on the SUMO Website.

ELSA activities in RP2. (opens in new window)

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicable with the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Publications

Coordination between endoderm progression and gastruloid elongation controls endodermal morphotype choice (opens in new window)

Author(s): 1. Farag N, Schiff C, Nachman I
Published in: Cold Spring Harbor Laboratory, 2023, ISSN 2692-8205
Publisher: Developmental Cell/Cell Systems
DOI: 10.1101/2023.02.07.527329

Criteria for the standardization of stem-cell-based embryo models (opens in new window)

Author(s): Alfonso Martinez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam, Cantas Alev, Jianping Fu, Anna-Katerina Hadjantonakis, Jacob H. Hanna, Gabriella Minchiotti, Olivier Pourquie, Guojun Sheng, Liliana Solnica Krezel, Jesse V. Veenvliet, Aryeh Warmflash
Published in: Nature Cell Biology, Issue 26, 2024, ISSN 1465-7392
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41556-024-01492-x

Dynamic governance: A new era for consent for stem cell research (opens in new window)

Author(s): Rosario Isasi, Heidi B. Bentzen, Morris Fabbri, Antonie Fuhr, Joel C. Glover, Nancy Mah, Deborah Mascalzoni, Sabine Mueller, Stefanie Seltmann, Andreas Kurtz
Published in: Stem Cell Reports, Issue 19, 2024, ISSN 2213-6711
Publisher: Elsevier BV
DOI: 10.1016/j.stemcr.2024.07.006

Criteria for the standardization of stem-cell-based embryo models (opens in new window)

Author(s): Alfonso Martinez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam, Cantas Alev, Jianping Fu, Anna-Katerina Hadjantonakis, Jacob H. Hanna, Gabriella Minchiotti, Olivier Pourquie, Guojun Sheng, Liliana Solnica Krezel, Jesse V. Veenvliet & Aryeh Warmflash
Published in: Nature Cell Biology, 2024, ISSN 1465-7392
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41556-024-01492-X

Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model (opens in new window)

Author(s): Alba Villaronga-Luque, Ryan G. Savill, Natalia López-Anguita, Adriano Bolondi, Sumit Garai, Seher Ipek Gassaloglu, Roua Rouatbi, Kathrin Schmeisser, Aayush Poddar, Lisa Bauer, Tiago Alves, Sofia Traikov, Jonathan Rodenfels, Triantafyllos Chavakis, Aydan Bulut-Karslioglu, Jesse V. Veenvliet
Published in: Cell Stem Cell, Issue 32, 2025, ISSN 1934-5909
Publisher: Elsevier BV
DOI: 10.1016/J.STEM.2025.03.012

Public Preferences for Digital Health Data Sharing: Discrete Choice Experiment Study in 12 European Countries (opens in new window)

Author(s): Roberta Biasiotto, Jennifer Viberg Johansson, Melaku Birhanu Alemu, Virginia Romano, Heidi Beate Bentzen, Jane Kaye, Mirko Ancillotti, Johanna Maria Catharina Blom, Gauthier Chassang, Dara Hallinan, Guðbjörg Andrea Jónsdóttir, Aníbal Monasterio Astobiza, Emmanuelle Rial-Sebbag, David Rodríguez-Arias, Nisha Shah, Lea Skovgaard, Ciara Staunton, Katharina Tschigg, Jorien Veldwijk, Deborah Mascalzoni
Published in: Journal of Medical Internet Research, Issue 25, 2023, ISSN 1438-8871
Publisher: JMIR Publications Inc.
DOI: 10.2196/47066

Gastruloid optimization. (opens in new window)

Author(s): Lara Avni 1, Naama Farag , Binita Ghosh , Iftach Nachman
Published in: Emerg Top Life Sci ., 2023, ISSN 2397-8554
Publisher: Portland Press
DOI: 10.1042/ETLS20230096

Public Preferences for Digital Health Data Sharing: Discrete Choice Experiment Study in 12 European Countries (opens in new window)

Author(s): Roberta Biasiotto, Jennifer Viberg Johansson, Melaku Birhanu Alemu, Virginia Romano, Heidi Beate Bentzen, Jane Kaye, Mirko Ancillotti, Johanna Maria Catharina Blom, Gauthier Chassang, Dara Hallinan, Gubjrg Andrea Jnsdttir, Anbal Monasterio Astobiza, Emmanuelle Rial-Sebbag, David Rodrguez-Arias, Nisha Shah, Lea Skovgaard, Ciara Staunton, Katharina Tschigg, Jorien Veldwijk, Deborah Mascalzoni
Published in: Journal of Medical Internet Research, Issue 25, 2023, ISSN 1438-8871
Publisher: JMIR Publications Inc.
DOI: 10.2196/47066

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