Supervised morphogenesis in gastruloids

Información del proyecto

SUMO

Identificador del acuerdo de subvención: 101071203

DOI

10.3030/101071203

Fecha de la firma de la CE 16 Septiembre 2022

Fecha de inicio 1 Noviembre 2022

Fecha de finalización 31 Octubre 2027

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 3 438 217,68

Aportación de la UE

€ 3 337 725,00

Coordinado por

OSLO UNIVERSITETSSYKEHUS HF
Norway

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (9)

Update preprint with results Objective 1.2. + data repository imaging (figshare) & single-cell (GEO) data; submission for publication

Successful identification of putative, targetable drivers of variation that can be precisely tuned to minimise variation (Task 1.2). Successful integration of molecular and phenotypic fingerprints. Update preprint with the results of Task 1.2. + data repository imaging (figshare) & single-cell (GEO) data; submission for publication. Link to updated preprint + data repository on SUMO website.

Community resource released as preprint + data repository (figshare) with results Objective 1.1.

Catalogue of gastruloid morphotypes across the [genetic background x culture condition matrix] with a focus on heart and gut tube formation efficiency & morphodynamics. Community resource released as preprint + data repository (figshare) with results Objective 1.1. Links to community resources on SUMO website.

ELSA activities in RP1

Report on the activities outcomes and planned follow up to address ethical legal and social aspects ELSA These activities include engagement with strategic partners including the public and dissemination of best practices and guidelines when applicable with the ELMs field Any confidential information related to these activities will be included in the technical periodic report

Website and project logo

Launch of SUMO website including project logo Including links to already available projectrelated data protocols computational frameworks Launch of the website will be coordinated with a press release via partner institutes and further promotion via social media of project partners Twitter Facebook ResearchGate LinkedIn

Contribution to the regulatory debate in RP1.

Report on the activities outcomes and planned follow up to assess and address the ELMs portfolio needs This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies Any confidential information related to these activities will be included in the technical periodic report

Portfolio’s Dissemination and communication activities RP1

Report in the form of a presentation andor written text which includes a description of the conducted activities their outcomes and planned followup events Prepared in collaboration with the Media Services and Outreach Facility of the MPICBG Dresden MPG The report will be shared on the SUMO Website

Contribution to the regulatory debate in RP2

Report on the activities, outcomes and planned follow up to assess and address the ELMs portfolio needs. This includes contribution to the regulatory debate by engaging early on and continuously with regulatory bodies. Any confidential information related to these activities will be included in the technical periodic report

Portfolio’s Dissemination and communication activities RP2

Report in the form of a presentation and/or written text, which includes a description of the conducted activities, their outcomes and planned follow-up events. Prepared in collaboration with the Media Services and Outreach Facility of the MPI-CBG (Dresden, MPG). The report will be shared on the SUMO Website.

ELSA activities in RP2.

Report on the activities, outcomes and planned follow up to address ethical, legal and social aspects (ELSA). These activities include engagement with strategic partners (including the public), and dissemination of best practices and guidelines when applicable with the ELMs field. Any confidential information related to these activities will be included in the technical periodic report.

Other (2)

Algorithm for forward prediction of cell state in 3D multi-lineage gastruloids; Preprint, submission publication + code repository
Code to learn classifiers/regressors & multivariate feature analysis, deposited on GitHub

Successful establishment of code to learn classifiers/regressors & multivariate feature analysis, deposited on GitHub. Link to code on SUMO Website.

Publicaciones

Peer reviewed articles (11)

A guide to using embedded ethics in human stem-cell-based embryo model research

Autores: Heidi Beate Bentzen, Maxence Gaillard, Iftach Nachman, Daniel Reumann, Nikolaj Gadegaard, Laurent David, Fredrik Lanner, Naomi Moris, Vincent Pasque, Nicolas Rivron, Berna Sozen, Rosario Isasi, Stefan Krauss, Jesse V. Veenvliet
Publicado en: Nature Cell Biology, Edición 28, 2026, ISSN 1465-7392
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41556-026-01909-9

Coordination between endoderm progression and gastruloid elongation controls endodermal morphotype choice

Autores: 1. Farag N, Schiff C, Nachman I
Publicado en: Cold Spring Harbor Laboratory, 2023, ISSN 2692-8205
Editor: Developmental Cell/Cell Systems
DOI: 10.1101/2023.02.07.527329

If it ain’t broke, don’t fix it? Ten improvements for the upcoming tenth anniversary of the General Data Protection Regulation

Autores: Dariusz Kloza, Laura Drechsler, Elora Fernandes, Arian Birth, Julien Rossi, Pierre Dewitte, Jarosław Greser, Lisette Mustert, Gianclaudio Malgieri, Heidi Beate Bentzen
Publicado en: Computer Law & Security Review, Edición 60, 2026, ISSN 2212-473X
Editor: Elsevier BV
DOI: 10.1016/J.CLSR.2025.106251

Label-free biochemical imaging and time point analysis of neural organoids via deep learning–enhanced Raman microspectroscopy

Autores: Dimitar Georgiev, Ruoxiao Xie, Daniel Reumann, Xiaoyu Zhao, Álvaro Fernández-Galiana, Mauricio Barahona, Molly M. Stevens
Publicado en: Science Advances, Edición 12, 2026, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.AEC5080

Placental Syncytium‐on‐Chip (PSoC)–Comparison of Forskolin or Mechanical Induced‐Syncytialization

Autores: Ludivine Delon, Mathias Busek, Pedro Duarte Menezes, Nikolaj Gadegaard, Justyna Stokowiec, Alexey Golovin, Yuliia Boichuk, Thomas Combriat, Aleksandra Aizenshtadt, Stefan Krauss
Publicado en: Advanced Healthcare Materials, Edición 14, 2025, ISSN 2192-2640
Editor: Wiley
DOI: 10.1002/ADHM.202404462

Dynamic governance: A new era for consent for stem cell research

Autores: Rosario Isasi 1, Heidi B Bentzen 2, Morris Fabbri 3, Antonie Fuhr 4, Joel C Glover 5, Nancy Mah 4, Deborah Mascalzoni 6, Sabine Mueller 4, Stefanie Seltmann 4, Andreas Kurtz 4
Publicado en: Stem Cell Reports, ISSN 2213-6711
Editor: Elsevier BV
DOI: 10.1016/J.STEMCR.2024.07.006

Public Preferences for Digital Health Data Sharing: Discrete Choice Experiment Study in 12 European Countries

Autores: Roberta Biasiotto1, 2 Author Orcid Image ; Jennifer Viberg Johansson3 Author Orcid Image ; Melaku Birhanu Alemu4, 5 Author Orcid Image ; Virginia Romano1 Author Orcid Image ; Heidi Beate Bentzen6, 7 Author Orcid Image ; Jane Kaye8, 9 Author Orcid Ima
Publicado en: Journal of Medical Internet Research, ISSN 1438-8871
Editor: JMIR Publications Inc.
DOI: 10.2196/47066

Criteria for the standardization of stem-cell-based embryo models

Autores: Alfonso Martinez Arias, Nicolas Rivron, Naomi Moris, Patrick Tam, Cantas Alev, Jianping Fu, Anna-Katerina Hadjantonakis, Jacob H. Hanna, Gabriella Minchiotti, Olivier Pourquie, Guojun Sheng, Liliana Solnica Krezel, Jesse V. Veenvliet & Aryeh Warmflash
Publicado en: Nature Cell Biology, 2024, ISSN 1465-7392
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41556-024-01492-X

Integrated molecular-phenotypic profiling reveals metabolic control of morphological variation in a stem-cell-based embryo model

Autores: Alba Villaronga-Luque, Ryan G. Savill, Natalia López-Anguita, Adriano Bolondi, Sumit Garai, Seher Ipek Gassaloglu, Roua Rouatbi, Kathrin Schmeisser, Aayush Poddar, Lisa Bauer, Tiago Alves, Sofia Traikov, Jonathan Rodenfels, Triantafyllos Chavakis, Aydan Bulut-Karslioglu, Jesse V. Veenvliet
Publicado en: Cell Stem Cell, Edición 32, 2025, ISSN 1934-5909
Editor: Elsevier BV
DOI: 10.1016/J.STEM.2025.03.012

Extracellular matrix properties, interstitial flow, and VEGF gradients shape trophoblast behavior in a pumpless Trophoblast Invasion-on-Chip (TIoC)

Autores: Ludivine Claude Delon, Mathias Busek, Dilara Lal Lal, Renee Celine Heesakkers, Thea Josefine Wergeland, Justyna Stokowiec, Agata Julianna Socha, Thomas Michel Combriat, Alexey Golovin, Yuliia Boichuk, Stefan Krauss
Publicado en: Biomaterials, Edición 334, 2026, ISSN 0142-9612
Editor: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2026.124230

Gastruloid optimization.

Autores: Lara Avni 1, Naama Farag , Binita Ghosh , Iftach Nachman
Publicado en: Emerg Top Life Sci ., 2023, ISSN 2397-8554
Editor: Portland Press
DOI: 10.1042/ETLS20230096

Conference proceedings (1)

A Continuous and Interpretable Morphometric for Robust Quantification of Dynamic Biological Shapes

Autores: Roua Rouatbi, Juan-Esteban Suarez Cardona, Alba Villaronga-Luque, Jesse V. Veenvliet, Ivo F. Sbalzarini
Publicado en: IEEE ISBI / Arxiv
Editor: ArXiv
DOI: 10.48550/ARXIV.2410.21004

Book chapters (1)

Human organoids. Things or data?

Autores: Heidi Beate Bentzen
Publicado en: Confidentiality, Privacy, and Data Protection in Biomedicine, ISBN 9781003394518
Editor: Routledge
DOI: 10.4324/9781003394518-15/HUMAN-ORGANOIDS-HEIDI-BEATE-BENTZEN