Glycans as Master Switches of B Cell Activity in Autoimmunity

Project Information

GlycanSwitch

Grant agreement ID: 101071386

DOI

10.3030/101071386

EC signature date 14 December 2022

Start date 1 January 2023

End date 31 December 2028

Funded under

• European Research Council (ERC)

Total cost

€ 9 997 500,00

EU contribution

€ 9 997 500,00

Coordinated by

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (35)

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Author(s): Sofia Shkunnikova, Anika Mijakovac, Lucija Sironic, Maja Hanic, Gordan Lauc, Marina Martinic Kavur
Published in: Biotechnology Advances, Issue 67, 2023, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/j.biotechadv.2023.108169

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Author(s): Fran Lukšić; Anika Mijakovac; Goran Josipović; Vedrana Vičić Bočkor; Jasminka Krištić; Ana Cindrić; Martina Vinicki; Filip Rokić; Oliver Vugrek; Gordan Lauc; Vlatka Zoldoš
Published in: Biomolecules, Vol 13, Iss 8, p 1245 (2023), 2023, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom13081245

Glycosylation signature of plasma IgA of critically ill COVID-19 patients

Author(s): Daniel P. Potaczek; Daniel P. Potaczek; Daniel P. Potaczek; Bianca D. M. van Tol; David Falck; Christina Krolczik; Kristina Zlatina; Wilhelm Bertrams; Jochen Wilhelm; Bernd Schmeck; Benjamin Seeliger; Benjamin Seeliger; Sascha David; Chrysanthi Skevaki; Elisabeth Mack; Werner Seeger; Werner Seeger; Liliana Schaefer; Sebastian P. Galuska; Manfred Wuhrer; Małgorzata Wygrecka; Małgorzata Wygrecka; Małgorzata Wygrecka
Published in: Frontiers in Immunology, 2024, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.5167/UZH-264867

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

Author(s): Hoshi, Rosangela A Plavša, Branimir Liu, Yanyan Trbojević-Akmačić, Irena Glynn, Robert J Ridker, Paul M Cummings, Richard Gudelj, Ivan Lauc, Gordan Demler, Olga V Mora, Samia
Published in: Circulation Research, 2024, ISSN 1524-4571
Publisher: Lippincott Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.123.323623

GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC-MS readout

Author(s): David Falck and Manfred Wuhrer
Published in: Nature protocols, 2024, ISSN 1750-2799
Publisher: Springer Nature Limited
DOI: 10.1038/s41596-024-00963-7

An Integrated Glycosylation Signature of Rheumatoid Arthritis

Author(s): Oleg A. Mayboroda; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer; Radboud J. E. M. Dolhain
Published in: Biomolecules; Volume 13; Issue 7; Pages: 1106, 2023, ISSN 2218-273X
Publisher: Biomolecules
DOI: 10.3390/biom13071106

Mapping of the gene network that regulates glycan clock of ageing

Author(s): Azra Frkatović-Hodžić; Karlo Miškec; Anika Mijakovac; Arina Nostaeva; Sodbo Z. Sharapov; Arianna Landini; Toomas Haller; Erik van den Akker; Sapna Sharma; Rafael R. C. Cuadrat; Massimo Mangino; Yong Li; Toma Keser; Najda Rudman; Tamara Štambuk; Maja Pučić-Baković; Irena Trbojević-Akmačić; Ivan Gudelj; Jerko Štambuk; Tea Pribić; Barbara Radovani; Petra Tominac; Krista Fischer; Marian Beekman; Manfred Wuhrer; Christian Gieger; Matthias B. Schulze; Clemens Wittenbecher; Ozren Polasek; Caroline Hayward; James F. Wilson; Tim D. Spector; Anna Köttgen; Frano Vučković; Yurii S. Aulchenko; Aleksandar Vojta; Jasminka Krištić; Lucija Klarić; Vlatka Zoldoš; Gordan Lauc
Published in: Aging, 2023, ISSN 1945-4589
Publisher: Impact Journals
DOI: 10.18632/aging.205106

Seminars in Immunology

Author(s): Roxane, Biersteker; Oliver F, Larsen; Manfred, Wuhrer; Tom W J, Huizinga; René E M, Toes; Lise, Hafkenscheid
Published in: Seminars in Immunology, 2025, ISSN 1044-5323
Publisher: Academic Press
DOI: 10.1016/J.SMIM.2025.101946

The role of glycans in personalization of preventive health care

Author(s): Gordan Lauc, Dragan Primorac
Published in: Croatian Medical Journal, 2024, ISSN 1332-8166
Publisher: Medicinska naklada, Vlaska 69, Zagreb, Croatia
DOI: 10.3325/cmj.2024.65.293

Nature Communications

Author(s): Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson & René E. M. Toes
Published in: Nature communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group (London)
DOI: 10.1038/s41467-023-44468-5

Fc proteoforms of ACPA IgG discriminate autoimmune responses in plasma and synovial fluid of rheumatoid arthritis patients and associate with disease activity

Author(s): Bloechl, C.; Stork, E.M.; Scherer, H.U.; Toes, R.E.M.; Wuhrer, M.; Dominguez-Vega, E.
Published in: Advanced Science, 2024, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/ADVS.202408769

Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G

Author(s): Šimunić-Briški, Nina; Dukarić, Vedran; Očić, Mateja; Madžar, Tomislav; Vinicki, Martina; Frkatović-Hodžić, Azra; Knjaz, Damir; Lauc, Gordan
Published in: Glycoconj J, 2023, ISSN 1573-4986
Publisher: Springer Nature
DOI: 10.1007/s10719-023-10144-5

The Role of Clinical Glyco(proteo)mics in Precision Medicine

Author(s): Yuri van der Burgt; Manfred Wuhrer
Published in: Crossref, 2023, ISSN 1535-9484
Publisher: Mol Cell Proteomics
DOI: 10.1016/j.mcpro.2023.100565

“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”

Author(s): Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SS
Published in: Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, ISSN 1872-8006
Publisher: Amsterdam : Elsevier
DOI: 10.1016/J.BBAGEN.2025.130779

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Author(s): Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Published in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Publisher: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability

Author(s): Rapčan, B., Song, M., Frkatović-Hodžić, A. et al.
Published in: Geroscience, 2024, ISSN 2509-2723
Publisher: SPRINGER
DOI: 10.1007/s11357-024-01239-4

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Author(s): Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Manuel; Sousa, Ana E.; Pinho, Salomé S.
Published in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Publisher: Nature Publishing Group
DOI: 10.1038/s41423-023-01052-7

The importance of <scp>IgG</scp> glycosylation—What did we learn after analyzing over 100,000 individuals

Author(s): Jasminka Krištić; Gordan Lauc
Published in: Immunological Reviews, 2024, ISSN 1600-065X
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/IMR.13407

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease

Author(s): Maja, Hanić; Frano, Vučković; Helena, Deriš; Claire, Bewshea; Simeng, Lin; James R, Goodhand; Tariq, Ahmad; Irena, Trbojević-Akmačić; Nicholas A, Kennedy; Gordan, Lauc; Stephen, Gore
Published in: Biomolecules, Vol 13, Iss 6, p 954 (2023), 2023, ISSN 2218-273X
Publisher: MDPI
DOI: 10.3390/biom13060954

Simultaneous Protein Quantitation and Glycosylation Profiling of Antigen-Specific Immunoglobulin G1 in Large Clinical Studies

Author(s): Steinar Gijze; Anna Wasynczuk; Leanne van Leeuwen; Marloes Grobben; Marit J. van Gils; Jan Nouta; Wenjun Wang; Virgil ASH Dalm; Hetty Jolink; Manfred Wuhrer; David Falck
Published in: Journal of Proteome Research, 2024, ISSN 1535-3907
Publisher: Journal of proteome Research ACS pubblications
DOI: 10.1021/acs.jproteome.4c00538

The Human Blood <i>N</i>-Glycome: Unraveling Disease Glycosylation Patterns

Author(s): Tamas Pongracz; Oleg A. Mayboroda; Manfred Wuhrer
Published in: JACS Au, Vol 4, Iss 5, Pp 1696-1708 (2024), 2024, ISSN 2691-3704
Publisher: JACS AU
DOI: 10.1021/jacsau.4c00043

Comprehensive Immunoglobulin G, A, and M Glycopeptide Profiling for Large-Scale Biomedical Research

Author(s): Bianca D.M. van Tol; Anna M. Wasynczuk; Steinar Gijze; Oleg A. Mayboroda; Jan Nouta; Radboud J.E.M. Dolhain; Manfred Wuhrer; David Falck
Published in: Molecular &amp; Cellular Proteomics, 2025, ISSN 1535-9484
Publisher: Elsevier
DOI: 10.1016/J.MCPRO.2025.100928

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Author(s): Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Published in: Carbohydrate Research, Issue 544, 2024, ISSN 0008-6215
Publisher: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Author(s): Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Published in: Trends in Immunology, 2023, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/j.it.2023.06.004

Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays

Author(s): Biersteker, R.; Athanasiadou, A.; Meulen, S. van der; Wesemael, T.J. van; Slot, L.M.; Kissel, T.; Toes, R.E.M.; Trouw, L.A.; Woude, D. van der
Published in: Arthritis Research &amp; Therapy, 2025, ISSN 1478-6362
Publisher: Springer Nature
DOI: 10.1186/S13075-025-03591-Y

Cell Communication and Signaling

Author(s): Falck, David; Sokolova, Maria V.; Koeleman, Carolien A. M.; Irumva, Vanessa; Kirchner, Philipp; Schulz, Sebastian R.; Schmidt, Katja G.; Harrer, Thomas; Ekici, Arif B.; Spriewald, Bernd; Schett, Georg; Wuhrer, Manfred; Herrmann, Martin; Steffen, Ulrike
Published in: Cell Communication and Signaling, 2024, ISSN 1478-811X
Publisher: BioMed Central
DOI: 10.1186/S12964-025-02088-0

Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level

Author(s): Erik L. de Graaf; Mads Delbo Larsen; Nieke van der Bolt; Remco Visser; Onno J. H. M. Verhagen; Agnes L. Hipgrave Ederveen; Carolien A. M. Koeleman; C. Ellen van der Schoot; Manfred Wuhrer; Gestur Vidarsson
Published in: Immunology, 2023, ISSN 1521-4141
Publisher: Wiley Online Library
DOI: 10.1111/imm.13737

Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation

Author(s): Roxane Biersteker; Leoni Abendstein; Sanne van de Bovenkamp; Hugo J van Dooren; Sebastiaan M W R Hamers; Joanneke C Kwekkeboom; Eva Maria Stork; Jan W Drijfhout; Theo Rispens; Carolien A M Koeleman; Manfred Wuhrer; Leendert A Trouw; Thomas H Sharp; René E M Toes; Theresa Kissel
Published in: PNAS Nexus, 2025, ISSN 2752-6542
Publisher: PNAS Nexus
DOI: 10.1093/PNASNEXUS/PGAF216

GlycoDash: automated, visually assisted curation of glycoproteomics datasets for large sample numbers

Author(s): Tamas Pongracz; Steinar Gijze; Agnes L. Hipgrave Ederveen; Rico J. E. Derks; David Falck
Published in: Analytical and Bioanalytical Chemistry, 2025, ISSN 1618-2650
Publisher: SprinterNature
DOI: 10.1007/S00216-025-05794-3

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

Author(s): Eduarda Leite-Gomes; Mariana C Silva; Ana M Dias; Ângela Fernandes; Guilherme Faria; Rafaela Nogueira; Beatriz Santos-Pereira; Henrique Fernandes-Mendes; Catarina M Azevedo; Joana Raposo; Julian López Portero; Tania de Alda Catalá; Carlos Taxonera; Paula Lago; Maria J Fernandez-Aceñero; Isadora Rosa; Ricardo Marcos-Pinto; Salomé S Pinho
Published in: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Publisher: Amsterdam : Elsevier Science
DOI: 10.1093/ECCO-JCC/JJAF043

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Author(s): Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Nature Communications

Author(s): Eva Maria Stork; Danique M. H. van Rijswijck; Karin A. van Schie; Max Hoek; Theresa Kissel; Hans Ulrich Scherer; Tom W. J. Huizinga; Albert J. R. Heck; Rene E. M. Toes; Albert Bondt
Published in: Nat Commun, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Fc Profiling of Polyclonal IgG, IgA and IgM by Light Chain Capturing Coupled with NanoRP-LC-MS

Author(s): Yue Li; Sabrina Reusch; Bianca D. M. van Tol; Fiammetta Di Marco; Anna M. Wasynczuk; Steinar Gijze; David Falck; Manfred Wuhrer; Constantin Blöchl; Christoph Gstöttner; Elena Domínguez-Vega
Published in: JACS Au, 2025, ISSN 2691-3704
Publisher: ACS publications
DOI: 10.1021/JACSAU.5C00839

Reprogramming CD8+ T-cell Branched <i>N-</i> Glycosylation Limits Exhaustion, Enhancing Cytotoxicity and Tumor Killing

Author(s): Catarina M. Azevedo; Bingxian Xie; William G. Gunn; Ronal M. Peralta; Carolina S. Dantas; Henrique Fernandes-Mendes; Supriya Joshi; Victoria Dean; Pedro Almeida; Drew Wilfahrt; Nuno Mendes; Julian López Portero; Carmen Poves; María Jesús Fernández-Aceñero; Ricardo Marcos-Pinto; Ângela Fernandes; Greg M. Delgoffe; Salomé S. Pinho
Published in: Cancer Immunology Research, 2025, ISSN 2326-6074
Publisher: Philadelphia, PA : American Association for Cancer Research
DOI: 10.1158/2326-6066.CIR-25-0313

Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis

Author(s): Wesemael, T.J. van; Morton, F.R.; Heutz, J.W.; Maurits, M.P.; Dorjée, A.L.; Porter, D.; Huizinga, T.W.J.; Raza, K.; Toes, R.E.M.; Knevel, R.; Jong, P.H.P. de; Svärd, A.; Woude, D. van der
Published in: Arthritis Research &amp; Therapy, 2025, ISSN 1478-6362
Publisher: BiomedCentral London
DOI: 10.1186/S13075-025-03543-6

Other (2)

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Author(s): Theresa Kissel; Veerle F. A. M. Derksen; Arthur E. H. Bentlage; Carolien Koeleman; Lise Hafkenscheid; Diane van der Woude; Manfred Wuhrer; Gestur Vidarsson; René E. M. Toes
Published in: Nat Commun, 2024
Publisher: Nature
DOI: 10.1038/s41467-023-44468-5

Analytical Chemistry

Author(s): Tao Zhang; Wenjun Wang; Manfred Wuhrer; Noortje de Haan
Published in: Anal Chem, 2024, ISSN 0003-2700
Publisher: American Chemical Society
DOI: 10.1021/acs.analchem.3c05826