Glycans as Master Switches of B Cell Activity in Autoimmunity

Información del proyecto

GlycanSwitch

Identificador del acuerdo de subvención: 101071386

DOI

10.3030/101071386

Fecha de la firma de la CE 14 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2028

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 9 997 500,00

Aportación de la UE

€ 9 997 500,00

Coordinado por

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (35)

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Autores: Sofia Shkunnikova, Anika Mijakovac, Lucija Sironic, Maja Hanic, Gordan Lauc, Marina Martinic Kavur
Publicado en: Biotechnology Advances, Edición 67, 2023, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2023.108169

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Autores: Fran Lukšić; Anika Mijakovac; Goran Josipović; Vedrana Vičić Bočkor; Jasminka Krištić; Ana Cindrić; Martina Vinicki; Filip Rokić; Oliver Vugrek; Gordan Lauc; Vlatka Zoldoš
Publicado en: Biomolecules, Vol 13, Iss 8, p 1245 (2023), 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13081245

Glycosylation signature of plasma IgA of critically ill COVID-19 patients

Autores: Daniel P. Potaczek; Daniel P. Potaczek; Daniel P. Potaczek; Bianca D. M. van Tol; David Falck; Christina Krolczik; Kristina Zlatina; Wilhelm Bertrams; Jochen Wilhelm; Bernd Schmeck; Benjamin Seeliger; Benjamin Seeliger; Sascha David; Chrysanthi Skevaki; Elisabeth Mack; Werner Seeger; Werner Seeger; Liliana Schaefer; Sebastian P. Galuska; Manfred Wuhrer; Małgorzata Wygrecka; Małgorzata Wygrecka; Małgorzata Wygrecka
Publicado en: Frontiers in Immunology, 2024, ISSN 1664-3224
Editor: Frontiers
DOI: 10.5167/UZH-264867

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

Autores: Hoshi, Rosangela A Plavša, Branimir Liu, Yanyan Trbojević-Akmačić, Irena Glynn, Robert J Ridker, Paul M Cummings, Richard Gudelj, Ivan Lauc, Gordan Demler, Olga V Mora, Samia
Publicado en: Circulation Research, 2024, ISSN 1524-4571
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.123.323623

GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC-MS readout

Autores: David Falck and Manfred Wuhrer
Publicado en: Nature protocols, 2024, ISSN 1750-2799
Editor: Springer Nature Limited
DOI: 10.1038/s41596-024-00963-7

An Integrated Glycosylation Signature of Rheumatoid Arthritis

Autores: Oleg A. Mayboroda; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer; Radboud J. E. M. Dolhain
Publicado en: Biomolecules; Volume 13; Edición 7; Pages: 1106, 2023, ISSN 2218-273X
Editor: Biomolecules
DOI: 10.3390/biom13071106

Mapping of the gene network that regulates glycan clock of ageing

Autores: Azra Frkatović-Hodžić; Karlo Miškec; Anika Mijakovac; Arina Nostaeva; Sodbo Z. Sharapov; Arianna Landini; Toomas Haller; Erik van den Akker; Sapna Sharma; Rafael R. C. Cuadrat; Massimo Mangino; Yong Li; Toma Keser; Najda Rudman; Tamara Štambuk; Maja Pučić-Baković; Irena Trbojević-Akmačić; Ivan Gudelj; Jerko Štambuk; Tea Pribić; Barbara Radovani; Petra Tominac; Krista Fischer; Marian Beekman; Manfred Wuhrer; Christian Gieger; Matthias B. Schulze; Clemens Wittenbecher; Ozren Polasek; Caroline Hayward; James F. Wilson; Tim D. Spector; Anna Köttgen; Frano Vučković; Yurii S. Aulchenko; Aleksandar Vojta; Jasminka Krištić; Lucija Klarić; Vlatka Zoldoš; Gordan Lauc
Publicado en: Aging, 2023, ISSN 1945-4589
Editor: Impact Journals
DOI: 10.18632/aging.205106

Seminars in Immunology

Autores: Roxane, Biersteker; Oliver F, Larsen; Manfred, Wuhrer; Tom W J, Huizinga; René E M, Toes; Lise, Hafkenscheid
Publicado en: Seminars in Immunology, 2025, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/J.SMIM.2025.101946

The role of glycans in personalization of preventive health care

Autores: Gordan Lauc, Dragan Primorac
Publicado en: Croatian Medical Journal, 2024, ISSN 1332-8166
Editor: Medicinska naklada, Vlaska 69, Zagreb, Croatia
DOI: 10.3325/cmj.2024.65.293

Nature Communications

Autores: Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson & René E. M. Toes
Publicado en: Nature communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group (London)
DOI: 10.1038/s41467-023-44468-5

Fc proteoforms of ACPA IgG discriminate autoimmune responses in plasma and synovial fluid of rheumatoid arthritis patients and associate with disease activity

Autores: Bloechl, C.; Stork, E.M.; Scherer, H.U.; Toes, R.E.M.; Wuhrer, M.; Dominguez-Vega, E.
Publicado en: Advanced Science, 2024, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/ADVS.202408769

Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G

Autores: Šimunić-Briški, Nina; Dukarić, Vedran; Očić, Mateja; Madžar, Tomislav; Vinicki, Martina; Frkatović-Hodžić, Azra; Knjaz, Damir; Lauc, Gordan
Publicado en: Glycoconj J, 2023, ISSN 1573-4986
Editor: Springer Nature
DOI: 10.1007/s10719-023-10144-5

The Role of Clinical Glyco(proteo)mics in Precision Medicine

Autores: Yuri van der Burgt; Manfred Wuhrer
Publicado en: Crossref, 2023, ISSN 1535-9484
Editor: Mol Cell Proteomics
DOI: 10.1016/j.mcpro.2023.100565

“Mannose glycans as key players in trained immunity: A novel anti-tumoral catalyst”

Autores: Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SS
Publicado en: Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, ISSN 1872-8006
Editor: Amsterdam : Elsevier
DOI: 10.1016/J.BBAGEN.2025.130779

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Autores: Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editor: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability

Autores: Rapčan, B., Song, M., Frkatović-Hodžić, A. et al.
Publicado en: Geroscience, 2024, ISSN 2509-2723
Editor: SPRINGER
DOI: 10.1007/s11357-024-01239-4

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Autores: Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Manuel; Sousa, Ana E.; Pinho, Salomé S.
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editor: Nature Publishing Group
DOI: 10.1038/s41423-023-01052-7

The importance of <scp>IgG</scp> glycosylation—What did we learn after analyzing over 100,000 individuals

Autores: Jasminka Krištić; Gordan Lauc
Publicado en: Immunological Reviews, 2024, ISSN 1600-065X
Editor: John Wiley & Sons Ltd
DOI: 10.1111/IMR.13407

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease

Autores: Maja, Hanić; Frano, Vučković; Helena, Deriš; Claire, Bewshea; Simeng, Lin; James R, Goodhand; Tariq, Ahmad; Irena, Trbojević-Akmačić; Nicholas A, Kennedy; Gordan, Lauc; Stephen, Gore
Publicado en: Biomolecules, Vol 13, Iss 6, p 954 (2023), 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13060954

Simultaneous Protein Quantitation and Glycosylation Profiling of Antigen-Specific Immunoglobulin G1 in Large Clinical Studies

Autores: Steinar Gijze; Anna Wasynczuk; Leanne van Leeuwen; Marloes Grobben; Marit J. van Gils; Jan Nouta; Wenjun Wang; Virgil ASH Dalm; Hetty Jolink; Manfred Wuhrer; David Falck
Publicado en: Journal of Proteome Research, 2024, ISSN 1535-3907
Editor: Journal of proteome Research ACS pubblications
DOI: 10.1021/acs.jproteome.4c00538

The Human Blood <i>N</i>-Glycome: Unraveling Disease Glycosylation Patterns

Autores: Tamas Pongracz; Oleg A. Mayboroda; Manfred Wuhrer
Publicado en: JACS Au, Vol 4, Iss 5, Pp 1696-1708 (2024), 2024, ISSN 2691-3704
Editor: JACS AU
DOI: 10.1021/jacsau.4c00043

Comprehensive Immunoglobulin G, A, and M Glycopeptide Profiling for Large-Scale Biomedical Research

Autores: Bianca D.M. van Tol; Anna M. Wasynczuk; Steinar Gijze; Oleg A. Mayboroda; Jan Nouta; Radboud J.E.M. Dolhain; Manfred Wuhrer; David Falck
Publicado en: Molecular &amp; Cellular Proteomics, 2025, ISSN 1535-9484
Editor: Elsevier
DOI: 10.1016/J.MCPRO.2025.100928

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Autores: Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Publicado en: Carbohydrate Research, Edición 544, 2024, ISSN 0008-6215
Editor: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Autores: Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Publicado en: Trends in Immunology, 2023, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2023.06.004

Insights into the detection of AMPA cross-reactivity: comparing cyclic peptide- to protein-based assays

Autores: Biersteker, R.; Athanasiadou, A.; Meulen, S. van der; Wesemael, T.J. van; Slot, L.M.; Kissel, T.; Toes, R.E.M.; Trouw, L.A.; Woude, D. van der
Publicado en: Arthritis Research &amp; Therapy, 2025, ISSN 1478-6362
Editor: Springer Nature
DOI: 10.1186/S13075-025-03591-Y

Cell Communication and Signaling

Autores: Falck, David; Sokolova, Maria V.; Koeleman, Carolien A. M.; Irumva, Vanessa; Kirchner, Philipp; Schulz, Sebastian R.; Schmidt, Katja G.; Harrer, Thomas; Ekici, Arif B.; Spriewald, Bernd; Schett, Georg; Wuhrer, Manfred; Herrmann, Martin; Steffen, Ulrike
Publicado en: Cell Communication and Signaling, 2024, ISSN 1478-811X
Editor: BioMed Central
DOI: 10.1186/S12964-025-02088-0

Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level

Autores: Erik L. de Graaf; Mads Delbo Larsen; Nieke van der Bolt; Remco Visser; Onno J. H. M. Verhagen; Agnes L. Hipgrave Ederveen; Carolien A. M. Koeleman; C. Ellen van der Schoot; Manfred Wuhrer; Gestur Vidarsson
Publicado en: Immunology, 2023, ISSN 1521-4141
Editor: Wiley Online Library
DOI: 10.1111/imm.13737

Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation

Autores: Roxane Biersteker; Leoni Abendstein; Sanne van de Bovenkamp; Hugo J van Dooren; Sebastiaan M W R Hamers; Joanneke C Kwekkeboom; Eva Maria Stork; Jan W Drijfhout; Theo Rispens; Carolien A M Koeleman; Manfred Wuhrer; Leendert A Trouw; Thomas H Sharp; René E M Toes; Theresa Kissel
Publicado en: PNAS Nexus, 2025, ISSN 2752-6542
Editor: PNAS Nexus
DOI: 10.1093/PNASNEXUS/PGAF216

GlycoDash: automated, visually assisted curation of glycoproteomics datasets for large sample numbers

Autores: Tamas Pongracz; Steinar Gijze; Agnes L. Hipgrave Ederveen; Rico J. E. Derks; David Falck
Publicado en: Analytical and Bioanalytical Chemistry, 2025, ISSN 1618-2650
Editor: SprinterNature
DOI: 10.1007/S00216-025-05794-3

T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease

Autores: Eduarda Leite-Gomes; Mariana C Silva; Ana M Dias; Ângela Fernandes; Guilherme Faria; Rafaela Nogueira; Beatriz Santos-Pereira; Henrique Fernandes-Mendes; Catarina M Azevedo; Joana Raposo; Julian López Portero; Tania de Alda Catalá; Carlos Taxonera; Paula Lago; Maria J Fernandez-Aceñero; Isadora Rosa; Ricardo Marcos-Pinto; Salomé S Pinho
Publicado en: Journal of Crohn's and Colitis, 2025, ISSN 1876-4479
Editor: Amsterdam : Elsevier Science
DOI: 10.1093/ECCO-JCC/JJAF043

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Autores: Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Nature Communications

Autores: Eva Maria Stork; Danique M. H. van Rijswijck; Karin A. van Schie; Max Hoek; Theresa Kissel; Hans Ulrich Scherer; Tom W. J. Huizinga; Albert J. R. Heck; Rene E. M. Toes; Albert Bondt
Publicado en: Nat Commun, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Fc Profiling of Polyclonal IgG, IgA and IgM by Light Chain Capturing Coupled with NanoRP-LC-MS

Autores: Yue Li; Sabrina Reusch; Bianca D. M. van Tol; Fiammetta Di Marco; Anna M. Wasynczuk; Steinar Gijze; David Falck; Manfred Wuhrer; Constantin Blöchl; Christoph Gstöttner; Elena Domínguez-Vega
Publicado en: JACS Au, 2025, ISSN 2691-3704
Editor: ACS publications
DOI: 10.1021/JACSAU.5C00839

Reprogramming CD8+ T-cell Branched <i>N-</i> Glycosylation Limits Exhaustion, Enhancing Cytotoxicity and Tumor Killing

Autores: Catarina M. Azevedo; Bingxian Xie; William G. Gunn; Ronal M. Peralta; Carolina S. Dantas; Henrique Fernandes-Mendes; Supriya Joshi; Victoria Dean; Pedro Almeida; Drew Wilfahrt; Nuno Mendes; Julian López Portero; Carmen Poves; María Jesús Fernández-Aceñero; Ricardo Marcos-Pinto; Ângela Fernandes; Greg M. Delgoffe; Salomé S. Pinho
Publicado en: Cancer Immunology Research, 2025, ISSN 2326-6074
Editor: Philadelphia, PA : American Association for Cancer Research
DOI: 10.1158/2326-6066.CIR-25-0313

Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis

Autores: Wesemael, T.J. van; Morton, F.R.; Heutz, J.W.; Maurits, M.P.; Dorjée, A.L.; Porter, D.; Huizinga, T.W.J.; Raza, K.; Toes, R.E.M.; Knevel, R.; Jong, P.H.P. de; Svärd, A.; Woude, D. van der
Publicado en: Arthritis Research &amp; Therapy, 2025, ISSN 1478-6362
Editor: BiomedCentral London
DOI: 10.1186/S13075-025-03543-6

Other (2)

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Autores: Theresa Kissel; Veerle F. A. M. Derksen; Arthur E. H. Bentlage; Carolien Koeleman; Lise Hafkenscheid; Diane van der Woude; Manfred Wuhrer; Gestur Vidarsson; René E. M. Toes
Publicado en: Nat Commun, 2024
Editor: Nature
DOI: 10.1038/s41467-023-44468-5

Analytical Chemistry

Autores: Tao Zhang; Wenjun Wang; Manfred Wuhrer; Noortje de Haan
Publicado en: Anal Chem, 2024, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.3c05826