Glycans as Master Switches of B Cell Activity in Autoimmunity

Información del proyecto

GlycanSwitch

Identificador del acuerdo de subvención: 101071386

DOI

10.3030/101071386

Fecha de la firma de la CE 14 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2028

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 9 997 500,00

Aportación de la UE

€ 9 997 500,00

Coordinado por

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (21)

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Autores: Sofia Shkunnikova, Anika Mijakovac, Lucija Sironic, Maja Hanic, Gordan Lauc, Marina Martinic Kavur
Publicado en: Biotechnology Advances, Edición 67, 2023, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2023.108169

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Autores: Fran Lukšić; Anika Mijakovac; Goran Josipović; Vedrana Vičić Bočkor; Jasminka Krištić; Ana Cindrić; Martina Vinicki; Filip Rokić; Oliver Vugrek; Gordan Lauc; Vlatka Zoldoš
Publicado en: Biomolecules, Vol 13, Iss 8, p 1245 (2023), 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13081245

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

Autores: Hoshi, Rosangela A Plavša, Branimir Liu, Yanyan Trbojević-Akmačić, Irena Glynn, Robert J Ridker, Paul M Cummings, Richard Gudelj, Ivan Lauc, Gordan Demler, Olga V Mora, Samia
Publicado en: Circulation Research, 2024, ISSN 1524-4571
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.123.323623

GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC-MS readout

Autores: David Falck and Manfred Wuhrer
Publicado en: Nature protocols, 2024, ISSN 1750-2799
Editor: Springer Nature Limited
DOI: 10.1038/s41596-024-00963-7

An Integrated Glycosylation Signature of Rheumatoid Arthritis

Autores: Oleg A. Mayboroda; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer; Radboud J. E. M. Dolhain
Publicado en: Biomolecules; Volume 13; Edición 7; Pages: 1106, 2023, ISSN 2218-273X
Editor: Biomolecules
DOI: 10.3390/biom13071106

Mapping of the gene network that regulates glycan clock of ageing

Autores: Azra Frkatović-Hodžić; Karlo Miškec; Anika Mijakovac; Arina Nostaeva; Sodbo Z. Sharapov; Arianna Landini; Toomas Haller; Erik van den Akker; Sapna Sharma; Rafael R. C. Cuadrat; Massimo Mangino; Yong Li; Toma Keser; Najda Rudman; Tamara Štambuk; Maja Pučić-Baković; Irena Trbojević-Akmačić; Ivan Gudelj; Jerko Štambuk; Tea Pribić; Barbara Radovani; Petra Tominac; Krista Fischer; Marian Beekman; Manfred Wuhrer; Christian Gieger; Matthias B. Schulze; Clemens Wittenbecher; Ozren Polasek; Caroline Hayward; James F. Wilson; Tim D. Spector; Anna Köttgen; Frano Vučković; Yurii S. Aulchenko; Aleksandar Vojta; Jasminka Krištić; Lucija Klarić; Vlatka Zoldoš; Gordan Lauc
Publicado en: Aging, 2023, ISSN 1945-4589
Editor: Impact Journals
DOI: 10.18632/aging.205106

The role of glycans in personalization of preventive health care

Autores: Gordan Lauc, Dragan Primorac
Publicado en: Croatian Medical Journal, 2024, ISSN 1332-8166
Editor: Medicinska naklada, Vlaska 69, Zagreb, Croatia
DOI: 10.3325/cmj.2024.65.293

Nature Communications

Autores: Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson & René E. M. Toes
Publicado en: Nature communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group (London)
DOI: 10.1038/s41467-023-44468-5

Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G

Autores: Šimunić-Briški, Nina; Dukarić, Vedran; Očić, Mateja; Madžar, Tomislav; Vinicki, Martina; Frkatović-Hodžić, Azra; Knjaz, Damir; Lauc, Gordan
Publicado en: Glycoconj J, 2023, ISSN 1573-4986
Editor: Springer Nature
DOI: 10.1007/s10719-023-10144-5

The Role of Clinical Glyco(proteo)mics in Precision Medicine

Autores: Yuri van der Burgt; Manfred Wuhrer
Publicado en: Crossref, 2023, ISSN 1535-9484
Editor: Mol Cell Proteomics
DOI: 10.1016/j.mcpro.2023.100565

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Autores: Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editor: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability

Autores: Rapčan, B., Song, M., Frkatović-Hodžić, A. et al.
Publicado en: Geroscience, 2024, ISSN 2509-2723
Editor: SPRINGER
DOI: 10.1007/s11357-024-01239-4

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Autores: Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Manuel; Sousa, Ana E.; Pinho, Salomé S.
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editor: Nature Publishing Group
DOI: 10.1038/s41423-023-01052-7

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease

Autores: Maja, Hanić; Frano, Vučković; Helena, Deriš; Claire, Bewshea; Simeng, Lin; James R, Goodhand; Tariq, Ahmad; Irena, Trbojević-Akmačić; Nicholas A, Kennedy; Gordan, Lauc; Stephen, Gore
Publicado en: Biomolecules, Vol 13, Iss 6, p 954 (2023), 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13060954

Simultaneous Protein Quantitation and Glycosylation Profiling of Antigen-Specific Immunoglobulin G1 in Large Clinical Studies

Autores: Steinar Gijze; Anna Wasynczuk; Leanne van Leeuwen; Marloes Grobben; Marit J. van Gils; Jan Nouta; Wenjun Wang; Virgil ASH Dalm; Hetty Jolink; Manfred Wuhrer; David Falck
Publicado en: Journal of Proteome Research, 2024, ISSN 1535-3907
Editor: Journal of proteome Research ACS pubblications
DOI: 10.1021/acs.jproteome.4c00538

The Human Blood <i>N</i>-Glycome: Unraveling Disease Glycosylation Patterns

Autores: Tamas Pongracz; Oleg A. Mayboroda; Manfred Wuhrer
Publicado en: JACS Au, Vol 4, Iss 5, Pp 1696-1708 (2024), 2024, ISSN 2691-3704
Editor: JACS AU
DOI: 10.1021/jacsau.4c00043

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Autores: Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Publicado en: Carbohydrate Research, Edición 544, 2024, ISSN 0008-6215
Editor: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Autores: Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Publicado en: Trends in Immunology, 2023, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2023.06.004

Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level

Autores: Erik L. de Graaf; Mads Delbo Larsen; Nieke van der Bolt; Remco Visser; Onno J. H. M. Verhagen; Agnes L. Hipgrave Ederveen; Carolien A. M. Koeleman; C. Ellen van der Schoot; Manfred Wuhrer; Gestur Vidarsson
Publicado en: Immunology, 2023, ISSN 1521-4141
Editor: Wiley Online Library
DOI: 10.1111/imm.13737

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Autores: Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Publicado en: Nature Communications, Edición 16, 2025, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Nature Communications

Autores: Eva Maria Stork; Danique M. H. van Rijswijck; Karin A. van Schie; Max Hoek; Theresa Kissel; Hans Ulrich Scherer; Tom W. J. Huizinga; Albert J. R. Heck; Rene E. M. Toes; Albert Bondt
Publicado en: Nat Commun, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Other (2)

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Autores: Theresa Kissel; Veerle F. A. M. Derksen; Arthur E. H. Bentlage; Carolien Koeleman; Lise Hafkenscheid; Diane van der Woude; Manfred Wuhrer; Gestur Vidarsson; René E. M. Toes
Publicado en: Nat Commun, 2024
Editor: Nature
DOI: 10.1038/s41467-023-44468-5

Analytical Chemistry

Autores: Tao Zhang; Wenjun Wang; Manfred Wuhrer; Noortje de Haan
Publicado en: Anal Chem, 2024, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.3c05826