Glycans as Master Switches of B Cell Activity in Autoimmunity

Información del proyecto

GlycanSwitch

Identificador del acuerdo de subvención: 101071386

DOI 10.3030/101071386

Fecha de la firma de la CE 14 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2028

Financiado con arreglo a

• European Research Council (ERC)

Coste total € 9 997 500,00

Aportación de la UE € 9 997 500,00

Coordinado por

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (20)

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Autores: Sofia Shkunnikova, Anika Mijakovac, Lucija Sironic, Maja Hanic, Gordan Lauc, Marina Martinic Kavur
Publicado en: Biotechnology Advances, Edición 67, 2023, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2023.108169

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Autores: Fran Lukšić; Anika Mijakovac; Goran Josipović; Vedrana Vičić Bočkor; Jasminka Krištić; Ana Cindrić; Martina Vinicki; Filip Rokić; Oliver Vugrek; Gordan Lauc; Vlatka Zoldoš
Publicado en: Biomolecules, Vol 13, Iss 8, p 1245 (2023), 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13081245

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

Autores: Hoshi, Rosangela A Plavša, Branimir Liu, Yanyan Trbojević-Akmačić, Irena Glynn, Robert J Ridker, Paul M Cummings, Richard Gudelj, Ivan Lauc, Gordan Demler, Olga V Mora, Samia
Publicado en: Circulation Research, 2024, ISSN 1524-4571
Editor: Lippincott Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.123.323623

GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC-MS readout

Autores: David Falck and Manfred Wuhrer
Publicado en: Nature protocols, 2024, ISSN 1750-2799
Editor: Springer Nature Limited
DOI: 10.1038/s41596-024-00963-7

An Integrated Glycosylation Signature of Rheumatoid Arthritis

Autores: Oleg A. Mayboroda; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer; Radboud J. E. M. Dolhain
Publicado en: Biomolecules; Volume 13; Edición 7; Pages: 1106, 2023, ISSN 2218-273X
Editor: Biomolecules
DOI: 10.3390/biom13071106

Mapping of the gene network that regulates glycan clock of ageing

Autores: Azra Frkatović-Hodžić; Karlo Miškec; Anika Mijakovac; Arina Nostaeva; Sodbo Z. Sharapov; Arianna Landini; Toomas Haller; Erik van den Akker; Sapna Sharma; Rafael R. C. Cuadrat; Massimo Mangino; Yong Li; Toma Keser; Najda Rudman; Tamara Štambuk; Maja Pučić-Baković; Irena Trbojević-Akmačić; Ivan Gudelj; Jerko Štambuk; Tea Pribić; Barbara Radovani; Petra Tominac; Krista Fischer; Marian Beekman; Manfred Wuhrer; Christian Gieger; Matthias B. Schulze; Clemens Wittenbecher; Ozren Polasek; Caroline Hayward; James F. Wilson; Tim D. Spector; Anna Köttgen; Frano Vučković; Yurii S. Aulchenko; Aleksandar Vojta; Jasminka Krištić; Lucija Klarić; Vlatka Zoldoš; Gordan Lauc
Publicado en: Aging, 2023, ISSN 1945-4589
Editor: Impact Journals
DOI: 10.18632/aging.205106

The role of glycans in personalization of preventive health care

Autores: Gordan Lauc, Dragan Primorac
Publicado en: Croatian Medical Journal, 2024, ISSN 1332-8166
Editor: Medicinska naklada, Vlaska 69, Zagreb, Croatia
DOI: 10.3325/cmj.2024.65.293

Nature Communications

Autores: Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson & René E. M. Toes
Publicado en: Nature communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group (London)
DOI: 10.1038/s41467-023-44468-5

Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G

Autores: Šimunić-Briški, Nina; Dukarić, Vedran; Očić, Mateja; Madžar, Tomislav; Vinicki, Martina; Frkatović-Hodžić, Azra; Knjaz, Damir; Lauc, Gordan
Publicado en: Glycoconj J, 2023, ISSN 1573-4986
Editor: Springer Nature
DOI: 10.1007/s10719-023-10144-5

The Role of Clinical Glyco(proteo)mics in Precision Medicine

Autores: Yuri van der Burgt; Manfred Wuhrer
Publicado en: Crossref, 2023, ISSN 1535-9484
Editor: Mol Cell Proteomics
DOI: 10.1016/j.mcpro.2023.100565

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Autores: Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editor: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability

Autores: Rapčan, B., Song, M., Frkatović-Hodžić, A. et al.
Publicado en: Geroscience, 2024, ISSN 2509-2723
Editor: SPRINGER
DOI: 10.1007/s11357-024-01239-4

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Autores: Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Manuel; Sousa, Ana E.; Pinho, Salomé S.
Publicado en: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editor: Nature Publishing Group
DOI: 10.1038/s41423-023-01052-7

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease

Autores: Maja, Hanić; Frano, Vučković; Helena, Deriš; Claire, Bewshea; Simeng, Lin; James R, Goodhand; Tariq, Ahmad; Irena, Trbojević-Akmačić; Nicholas A, Kennedy; Gordan, Lauc; Stephen, Gore
Publicado en: Biomolecules, Vol 13, Iss 6, p 954 (2023), 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13060954

Simultaneous Protein Quantitation and Glycosylation Profiling of Antigen-Specific Immunoglobulin G1 in Large Clinical Studies

Autores: Steinar Gijze; Anna Wasynczuk; Leanne van Leeuwen; Marloes Grobben; Marit J. van Gils; Jan Nouta; Wenjun Wang; Virgil ASH Dalm; Hetty Jolink; Manfred Wuhrer; David Falck
Publicado en: Journal of Proteome Research, 2024, ISSN 1535-3907
Editor: Journal of proteome Research ACS pubblications
DOI: 10.1021/acs.jproteome.4c00538

The Human Blood <i>N</i>-Glycome: Unraveling Disease Glycosylation Patterns

Autores: Tamas Pongracz; Oleg A. Mayboroda; Manfred Wuhrer
Publicado en: JACS Au, Vol 4, Iss 5, Pp 1696-1708 (2024), 2024, ISSN 2691-3704
Editor: JACS AU
DOI: 10.1021/jacsau.4c00043

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Autores: Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Publicado en: Carbohydrate Research, Edición 544, 2024, ISSN 0008-6215
Editor: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Autores: Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Publicado en: Trends in Immunology, 2023, ISSN 1471-4906
Editor: Elsevier BV
DOI: 10.1016/j.it.2023.06.004

Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level

Autores: Erik L. de Graaf; Mads Delbo Larsen; Nieke van der Bolt; Remco Visser; Onno J. H. M. Verhagen; Agnes L. Hipgrave Ederveen; Carolien A. M. Koeleman; C. Ellen van der Schoot; Manfred Wuhrer; Gestur Vidarsson
Publicado en: Immunology, 2023, ISSN 1521-4141
Editor: Wiley Online Library
DOI: 10.1111/imm.13737

Nature Communications

Autores: Eva Maria Stork; Danique M. H. van Rijswijck; Karin A. van Schie; Max Hoek; Theresa Kissel; Hans Ulrich Scherer; Tom W. J. Huizinga; Albert J. R. Heck; Rene E. M. Toes; Albert Bondt
Publicado en: Nat Commun, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Other (2)

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Autores: Theresa Kissel; Veerle F. A. M. Derksen; Arthur E. H. Bentlage; Carolien Koeleman; Lise Hafkenscheid; Diane van der Woude; Manfred Wuhrer; Gestur Vidarsson; René E. M. Toes
Publicado en: Nat Commun, 2024
Editor: Nature
DOI: 10.1038/s41467-023-44468-5

Analytical Chemistry

Autores: Tao Zhang; Wenjun Wang; Manfred Wuhrer; Noortje de Haan
Publicado en: Anal Chem, 2024, ISSN 0003-2700
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.3c05826