Glycans as Master Switches of B Cell Activity in Autoimmunity

Informazioni relative al progetto

GlycanSwitch

ID dell’accordo di sovvenzione: 101071386

DOI

10.3030/101071386

Data della firma CE 14 Dicembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2028

Finanziato da

• European Research Council (ERC)

Costo totale

€ 9 997 500,00

Contributo UE

€ 9 997 500,00

Coordinato da

ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (21)

IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

Autori: Sofia Shkunnikova, Anika Mijakovac, Lucija Sironic, Maja Hanic, Gordan Lauc, Marina Martinic Kavur
Pubblicato in: Biotechnology Advances, Numero 67, 2023, ISSN 0734-9750
Editore: Elsevier BV
DOI: 10.1016/j.biotechadv.2023.108169

Long-Term Culturing of FreeStyle 293-F Cells Affects Immunoglobulin G Glycome Composition

Autori: Fran Lukšić; Anika Mijakovac; Goran Josipović; Vedrana Vičić Bočkor; Jasminka Krištić; Ana Cindrić; Martina Vinicki; Filip Rokić; Oliver Vugrek; Gordan Lauc; Vlatka Zoldoš
Pubblicato in: Biomolecules, Vol 13, Iss 8, p 1245 (2023), 2023, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom13081245

N-Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events

Autori: Hoshi, Rosangela A Plavša, Branimir Liu, Yanyan Trbojević-Akmačić, Irena Glynn, Robert J Ridker, Paul M Cummings, Richard Gudelj, Ivan Lauc, Gordan Demler, Olga V Mora, Samia
Pubblicato in: Circulation Research, 2024, ISSN 1524-4571
Editore: Lippincott Williams & Wilkins
DOI: 10.1161/CIRCRESAHA.123.323623

GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC-MS readout

Autori: David Falck and Manfred Wuhrer
Pubblicato in: Nature protocols, 2024, ISSN 1750-2799
Editore: Springer Nature Limited
DOI: 10.1038/s41596-024-00963-7

An Integrated Glycosylation Signature of Rheumatoid Arthritis

Autori: Oleg A. Mayboroda; Guinevere S. M. Lageveen-Kammeijer; Manfred Wuhrer; Radboud J. E. M. Dolhain
Pubblicato in: Biomolecules; Volume 13; Numero 7; Pages: 1106, 2023, ISSN 2218-273X
Editore: Biomolecules
DOI: 10.3390/biom13071106

Mapping of the gene network that regulates glycan clock of ageing

Autori: Azra Frkatović-Hodžić; Karlo Miškec; Anika Mijakovac; Arina Nostaeva; Sodbo Z. Sharapov; Arianna Landini; Toomas Haller; Erik van den Akker; Sapna Sharma; Rafael R. C. Cuadrat; Massimo Mangino; Yong Li; Toma Keser; Najda Rudman; Tamara Štambuk; Maja Pučić-Baković; Irena Trbojević-Akmačić; Ivan Gudelj; Jerko Štambuk; Tea Pribić; Barbara Radovani; Petra Tominac; Krista Fischer; Marian Beekman; Manfred Wuhrer; Christian Gieger; Matthias B. Schulze; Clemens Wittenbecher; Ozren Polasek; Caroline Hayward; James F. Wilson; Tim D. Spector; Anna Köttgen; Frano Vučković; Yurii S. Aulchenko; Aleksandar Vojta; Jasminka Krištić; Lucija Klarić; Vlatka Zoldoš; Gordan Lauc
Pubblicato in: Aging, 2023, ISSN 1945-4589
Editore: Impact Journals
DOI: 10.18632/aging.205106

The role of glycans in personalization of preventive health care

Autori: Gordan Lauc, Dragan Primorac
Pubblicato in: Croatian Medical Journal, 2024, ISSN 1332-8166
Editore: Medicinska naklada, Vlaska 69, Zagreb, Croatia
DOI: 10.3325/cmj.2024.65.293

Nature Communications

Autori: Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson & René E. M. Toes
Pubblicato in: Nature communications, Numero 15, 2024, ISSN 2041-1723
Editore: Nature Publishing Group (London)
DOI: 10.1038/s41467-023-44468-5

Regular moderate physical exercise decreases Glycan Age index of biological age and reduces inflammatory potential of Immunoglobulin G

Autori: Šimunić-Briški, Nina; Dukarić, Vedran; Očić, Mateja; Madžar, Tomislav; Vinicki, Martina; Frkatović-Hodžić, Azra; Knjaz, Damir; Lauc, Gordan
Pubblicato in: Glycoconj J, 2023, ISSN 1573-4986
Editore: Springer Nature
DOI: 10.1007/s10719-023-10144-5

The Role of Clinical Glyco(proteo)mics in Precision Medicine

Autori: Yuri van der Burgt; Manfred Wuhrer
Pubblicato in: Crossref, 2023, ISSN 1535-9484
Editore: Mol Cell Proteomics
DOI: 10.1016/j.mcpro.2023.100565

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

Autori: Salomé S. Pinho; Inês Alves; Joana Gaifem; Gabriel A. Rabinovich
Pubblicato in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editore: Chinese Society of Immunology
DOI: 10.1038/s41423-023-01074-1

Glycan clock of ageing—analytical precision and time-dependent inter- and i-individual variability

Autori: Rapčan, B., Song, M., Frkatović-Hodžić, A. et al.
Pubblicato in: Geroscience, 2024, ISSN 2509-2723
Editore: SPRINGER
DOI: 10.1007/s11357-024-01239-4

Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

Autori: Vicente, Manuel M.; Alves, Inês; Fernandes, Ângela; Dias, Ana M.; Santos-Pereira, Beatriz; Pérez-Anton, Elena; Santos, Sofia; Yang, Tao; Correia, Alexandra; Münster-Kühnel, Anja; Almeida, Afonso R. M.; Ravens, Sarina; Rabinovich, Gabriel A.; Vilanova, Manuel; Sousa, Ana E.; Pinho, Salomé S.
Pubblicato in: Cellular & Molecular Immunology, 2023, ISSN 1672-7681
Editore: Nature Publishing Group
DOI: 10.1038/s41423-023-01052-7

Anti-TNF Biologicals Enhance the Anti-Inflammatory Properties of IgG N-Glycome in Crohn’s Disease

Autori: Maja, Hanić; Frano, Vučković; Helena, Deriš; Claire, Bewshea; Simeng, Lin; James R, Goodhand; Tariq, Ahmad; Irena, Trbojević-Akmačić; Nicholas A, Kennedy; Gordan, Lauc; Stephen, Gore
Pubblicato in: Biomolecules, Vol 13, Iss 6, p 954 (2023), 2023, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom13060954

Simultaneous Protein Quantitation and Glycosylation Profiling of Antigen-Specific Immunoglobulin G1 in Large Clinical Studies

Autori: Steinar Gijze; Anna Wasynczuk; Leanne van Leeuwen; Marloes Grobben; Marit J. van Gils; Jan Nouta; Wenjun Wang; Virgil ASH Dalm; Hetty Jolink; Manfred Wuhrer; David Falck
Pubblicato in: Journal of Proteome Research, 2024, ISSN 1535-3907
Editore: Journal of proteome Research ACS pubblications
DOI: 10.1021/acs.jproteome.4c00538

The Human Blood <i>N</i>-Glycome: Unraveling Disease Glycosylation Patterns

Autori: Tamas Pongracz; Oleg A. Mayboroda; Manfred Wuhrer
Pubblicato in: JACS Au, Vol 4, Iss 5, Pp 1696-1708 (2024), 2024, ISSN 2691-3704
Editore: JACS AU
DOI: 10.1021/jacsau.4c00043

“Glycans in Trained Immunity: Educators of innate immune memory in homeostasis and disease”

Autori: Pedro Almeida, Ângela Fernandes, Inês Alves, Salomé S. Pinho
Pubblicato in: Carbohydrate Research, Numero 544, 2024, ISSN 0008-6215
Editore: Elsevier BV
DOI: 10.1016/j.carres.2024.109245

Glycome dynamics in T and B cell development: basic immunological mechanisms and clinical applications

Autori: Vicente, Manuel M.; Leite-Gomes, Eduarda; Pinho, Salomé S.
Pubblicato in: Trends in Immunology, 2023, ISSN 1471-4906
Editore: Elsevier BV
DOI: 10.1016/j.it.2023.06.004

Assessment of IgG‐Fc glycosylation from individual RhD‐specific B cell clones reveals regulation at clonal rather than clonotypic level

Autori: Erik L. de Graaf; Mads Delbo Larsen; Nieke van der Bolt; Remco Visser; Onno J. H. M. Verhagen; Agnes L. Hipgrave Ederveen; Carolien A. M. Koeleman; C. Ellen van der Schoot; Manfred Wuhrer; Gestur Vidarsson
Pubblicato in: Immunology, 2023, ISSN 1521-4141
Editore: Wiley Online Library
DOI: 10.1111/imm.13737

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Autori: Sodbo Sharapov, Anna Timoshchuk, Olga Zaytseva, Denis E. Maslov, Anna Soplenkova, Elizaveta E. Elgaeva, Evgeny S. Tiys, Massimo Mangino, Clemens Wittenbecher, Lennart Karssen, Maria Timofeeva, Arina Nostaeva, Frano Vuckovic, Irena Trbojević-Akmačić, Tamara Štambuk, Sofya Feoktistova, Nadezhda A. Potapova, Viktoria Voroshilova, Frances Williams, Dragan Primorac, Jan Van Zundert, Michel Georges, Karsten Suhre, Massimo Allegri, Nishi Chaturvedi, Malcolm Dunlop, Matthias B. Schulze, Tim Spector, Yakov A. Tsepilov, Gordan Lauc, Yurii S. Aulchenko
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-60431-Y

Nature Communications

Autori: Eva Maria Stork; Danique M. H. van Rijswijck; Karin A. van Schie; Max Hoek; Theresa Kissel; Hans Ulrich Scherer; Tom W. J. Huizinga; Albert J. R. Heck; Rene E. M. Toes; Albert Bondt
Pubblicato in: Nat Commun, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-024-47337-x

Other (2)

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Autori: Theresa Kissel; Veerle F. A. M. Derksen; Arthur E. H. Bentlage; Carolien Koeleman; Lise Hafkenscheid; Diane van der Woude; Manfred Wuhrer; Gestur Vidarsson; René E. M. Toes
Pubblicato in: Nat Commun, 2024
Editore: Nature
DOI: 10.1038/s41467-023-44468-5

Analytical Chemistry

Autori: Tao Zhang; Wenjun Wang; Manfred Wuhrer; Noortje de Haan
Pubblicato in: Anal Chem, 2024, ISSN 0003-2700
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.3c05826