**Scientific Summary:**
The CombiDiag project aims to advance research in early Alzheimer's disease (AD) diagnostics through cutting-edge scientific objectives and innovative methodologies. Significant progress has been made in discovering peripheral biomarkers from blood, saliva, urine, motor, speech, and sleep using laboratory-based techniques. Specifically, 26 metabolites have been identified as potential differentiators between AD patients and healthy controls, leading to the development of the NeuroDeGene® tool for early diagnosis.
The project also focuses on cross-validating these biomarkers through a proof-of-concept clinical study, developing an AI-driven diagnostic protocol for early AD detection, creating a data sharing platform, and conducting clinical validation trials. Additionally, efforts are underway to develop a business model for maximizing societal and economic impact.
The collaborative efforts of the partners involved have resulted in advancements in early AD diagnostics, leveraging data-driven approaches and multidisciplinary collaboration. These efforts aim to improve outcomes for individuals affected by AD by enhancing early detection and management strategies.
**Training Summary:**
CombiDiag's training program integrates a research platform with innovative training methodologies to achieve training objectives for Fellows. The program focuses on providing Fellows with interdisciplinary knowledge and skills spanning engineering, physical science, life science, healthcare, and business to prepare them for future career challenges.
Extensive training has been provided in domain-specific knowledge, hands-on experience, and transferable skills through supervision teams and personal mentoring. Additionally, training events and secondment opportunities with industrial, clinical, and international partners aim to enhance Fellows' triple-i and cultural diversity experience, innovative thinking, and business mindset.
The structured training program implements the Vitae Researcher Development Framework (Vitae RDF) methodology to equip Fellows with essential skills, knowledge, and personal qualities for leadership roles in early AD diagnostics research. The program focuses on developing Fellows into leading experts in their respective fields by providing diverse learning experiences and opportunities for career development.
