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A holistic approach to training a new generation of scientists in marine biodiscovery

Descripción del proyecto

Productos naturales microbianos marinos: del lecho marino a la cabecera del paciente

Los compuestos biológicamente activos producidos por microorganismos que viven en medios marinos pueden convertirse en nuevos fármacos y tratamientos para diversas enfermedades. Estos productos naturales microbianos marinos suelen tener estructuras y actividades biológicas únicas. El equipo del proyecto HOTBIO, que cuenta con el apoyo de las Acciones Marie Skłodowska-Curie, formará a científicos noveles para que estos productos pasen del descubrimiento a la comercialización. Ello abarca todas las fases del proceso de descubrimiento de fármacos, incluido el aislamiento microbiano, la purificación de compuestos, la identificación, la síntesis de análogos y el desarrollo de fármacos. El objetivo del equipo del proyecto es crear una nueva generación de científicos que puedan llevar estos prometedores compuestos a la cabecera del paciente, donde pueden tener un impacto positivo en la salud humana.

Objetivo

The HOTBIO consortium will train a new generation of early-stage scientists to take marine microbial natural products from the seabed to the bedside. They will be involved in every stage of the pipeline from microbial isolation through compound purification and identification to making analogues with desirable drug-like properties. They will gain associated skills in access and benefit sharing, intellectual property and entrepreneurship. Students graduating from HOTBIO will be in a unique position to enter a challenging labour market as they will have received multidisciplinary training at world leading research groups in academia as well as at industry partners. Mentorship will be provided by industrial scientists and recent graduates from the MSCA ITN MarPipe.

The HOTBIO consortium consists of eight beneficiaries from seven European countries, including two members from non-academic sectors, that will host ten PhD students. Three more PhD students hosted by two Swiss associated partners will be funded by the Swiss State Secretariat for Education, Research and Innovation. In addition to secondments at the partners in Europe, students will also get the opportunity to do secondments in low-to-middle income countries (LMICs) in Africa and Asia to get a deeper understanding of how modern research can be done in resource-limited setting.

HOTBIO expands a conventional marine biodiscovery pipeline by including computer aided drug design (CADD), chemical synthesis of optimized compounds (i.e. medicinal chemistry), target deconvolution and extensive ADMET profiling. This will advance the bioactive microbial secondary metabolites to the later stages of preclinical development, and it will also inform the decisions and priorities of what kind of compounds that should be targeted in the initial phase of the drug discovery process. The downstream development will include hit compounds from earlier projects.

Coordinador

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Aportación neta de la UEn
€ 595 497,60
Dirección
HANSINE HANSENS VEG 14
9019 Tromso
Noruega

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Región
Norge Nord-Norge Troms og Finnmark
Tipo de actividad
Higher or Secondary Education Establishments
Enlaces
Coste total
Sin datos

Participantes (6)

Socios (11)