European Commission logo
italiano italiano
CORDIS - Risultati della ricerca dell’UE
CORDIS

A holistic approach to training a new generation of scientists in marine biodiscovery

Descrizione del progetto

Prodotti naturali microbici marini: dalle profondità dell’oceano all’uso farmaceutico

I composti biologicamente attivi prodotti dai microrganismi che vivono negli ambienti marini possono essere sviluppati in nuovi farmaci e trattamenti per svariate malattie. Spesso tali prodotti microbici naturali marini presentano strutture e attività biologiche uniche nel loro genere. Grazie al sostegno del programma di azioni Marie Skłodowska-Curie, il progetto HOTBIO formerà scienziati in fase iniziale di carriera per portare questi prodotti dalla fase di scoperta a quella di commercializzazione. Per farlo, si occuperà di ogni stadio della pipeline di scoperta farmaceutica, compreso l’isolamento microbico, la purificazione dei composti, l’identificazione, la sintesi degli analoghi e lo sviluppo dei farmaci. L’obiettivo di HOTBIO è creare una nuova generazione di scienziati in grado di utilizzare tali composti in ambito medico, dove possono influenzare positivamente la salute umana.

Obiettivo

The HOTBIO consortium will train a new generation of early-stage scientists to take marine microbial natural products from the seabed to the bedside. They will be involved in every stage of the pipeline from microbial isolation through compound purification and identification to making analogues with desirable drug-like properties. They will gain associated skills in access and benefit sharing, intellectual property and entrepreneurship. Students graduating from HOTBIO will be in a unique position to enter a challenging labour market as they will have received multidisciplinary training at world leading research groups in academia as well as at industry partners. Mentorship will be provided by industrial scientists and recent graduates from the MSCA ITN MarPipe.

The HOTBIO consortium consists of eight beneficiaries from seven European countries, including two members from non-academic sectors, that will host ten PhD students. Three more PhD students hosted by two Swiss associated partners will be funded by the Swiss State Secretariat for Education, Research and Innovation. In addition to secondments at the partners in Europe, students will also get the opportunity to do secondments in low-to-middle income countries (LMICs) in Africa and Asia to get a deeper understanding of how modern research can be done in resource-limited setting.

HOTBIO expands a conventional marine biodiscovery pipeline by including computer aided drug design (CADD), chemical synthesis of optimized compounds (i.e. medicinal chemistry), target deconvolution and extensive ADMET profiling. This will advance the bioactive microbial secondary metabolites to the later stages of preclinical development, and it will also inform the decisions and priorities of what kind of compounds that should be targeted in the initial phase of the drug discovery process. The downstream development will include hit compounds from earlier projects.

Coordinatore

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Contribution nette de l'UE
€ 595 497,60
Indirizzo
HANSINE HANSENS VEG 14
9019 Tromso
Norvegia

Mostra sulla mappa

Regione
Norge Nord-Norge Troms og Finnmark
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato

Partecipanti (6)

Partner (11)