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CORDIS

A holistic approach to training a new generation of scientists in marine biodiscovery

Projektbeschreibung

Marine mikrobielle Naturstoffe: vom Meeresgrund zum Krankenbett

Biologisch aktive Verbindungen, die von in der Meeresumwelt lebenden Mikroorganismen produziert werden, können möglicherweise zur Entwicklung neuer Medikamente und Behandlungen für verschiedene Krankheiten genutzt werden. Diese marinen mikrobiellen Naturstoffe besitzen oft einzigartige Strukturen und biologische Aktivitäten. Mit Unterstützung der Marie-Skłodowska-Curie-Maßnahmen wird das Projekt HOTBIO Nachwuchsforschende ausbilden, um diese Produkte von der Entdeckung bis zur Vermarktung zu bringen. Dies betrifft alle Phasen der Arzneimittelforschung, einschließlich der Isolierung von Mikroorganismen, der Reinigung von Verbindungen, der Identifizierung, der Analogsynthese und der Arzneimittelentwicklung. Ziel des Projekts ist es, eine neue Generation von Forschenden heranzubilden, die diese vielversprechenden Wirkstoffe direkt am Krankenbett einsetzen können, wo sie sich positiv auf die menschliche Gesundheit auswirken können.

Ziel

The HOTBIO consortium will train a new generation of early-stage scientists to take marine microbial natural products from the seabed to the bedside. They will be involved in every stage of the pipeline from microbial isolation through compound purification and identification to making analogues with desirable drug-like properties. They will gain associated skills in access and benefit sharing, intellectual property and entrepreneurship. Students graduating from HOTBIO will be in a unique position to enter a challenging labour market as they will have received multidisciplinary training at world leading research groups in academia as well as at industry partners. Mentorship will be provided by industrial scientists and recent graduates from the MSCA ITN MarPipe.

The HOTBIO consortium consists of eight beneficiaries from seven European countries, including two members from non-academic sectors, that will host ten PhD students. Three more PhD students hosted by two Swiss associated partners will be funded by the Swiss State Secretariat for Education, Research and Innovation. In addition to secondments at the partners in Europe, students will also get the opportunity to do secondments in low-to-middle income countries (LMICs) in Africa and Asia to get a deeper understanding of how modern research can be done in resource-limited setting.

HOTBIO expands a conventional marine biodiscovery pipeline by including computer aided drug design (CADD), chemical synthesis of optimized compounds (i.e. medicinal chemistry), target deconvolution and extensive ADMET profiling. This will advance the bioactive microbial secondary metabolites to the later stages of preclinical development, and it will also inform the decisions and priorities of what kind of compounds that should be targeted in the initial phase of the drug discovery process. The downstream development will include hit compounds from earlier projects.

Koordinator

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Netto-EU-Beitrag
€ 595 497,60
Adresse
HANSINE HANSENS VEG 14
9019 Tromso
Norwegen

Auf der Karte ansehen

Region
Norge Nord-Norge Troms og Finnmark
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
Keine Daten

Beteiligte (6)

Partner (11)