Objective
Mitochondria produce most of the energy the body acquires through food, and are thus pivotal players in cellular metabolism. Central to mitochondrial biology is the DNA in the organelle (mtDNA): its maintenance, correct RNA processing, and efficient translation are all essential and must be coordinated to ensure proper mitochondrial function and cellular physiology. Defective maintenance or expression of mtDNA alters energy and nutrient metabolism, which are increasingly recognized to impact medical disciplines, ranging from hundreds of genetic disorders to neurodegeneration, immunology, transmissible disease, cancer and ageing. A deep understanding of the mitochondrial gene expression system and new methods are urgently needed to develop treatments for the full panoply of mitochondrial disorders that feature mtDNA perturbation.
MITGEST will unite world-class academic excellence in mtDNA maintenance and expression with private sector expertise in nucleic acid chemistry and the development of mitochondrial therapeutics to address this urgent need. As the first research training programme in this field to take a fully integrated approach, our 10 doctoral candidates (DC) will elucidate how mtDNA is maintained and expressed and support the development of new methods to analyse RNA and DNA metabolism in mitochondria. These advances will complement and facilitate/enhance innovative treatment strategies and experimental medicine studies designed to mitigate mitochondrial dysfunction in a range of human diseases.
Our network of 7 beneficiaries and 12 associated partners from 8 European countries and Israel builds on proven collaborations and establishes new partnerships to deliver intersectoral and multidisciplinary scientific and transferable skills training to our 11 PhD students to generate the next generation of highly-skilled scientists able to exploit the latest advances in mitochondrial biology and medicine.
Fields of science
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
02-247 Warszawa
Poland
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Participants (7)
6525 GA Nijmegen
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02 106 Warszawa
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17177 Stockholm
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20014 DONOSTIA-SAN SEBASTIAN
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82061 Neuried
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3902603 TIRAT HACARMEL
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Participation ended
33100 Udine
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Partners (16)
28049 Madrid
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
8008 ZURICH
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
20063 Cernusco Sul Naviglio
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
61 704 Poznan
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1105 AG Amsterdam
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6525 GC Nijmegen
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
WC1E 6BT London
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27100 Pavia
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CB5 8LA Cambridge
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
6525 XZ Nijmegen
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32000 Haifa
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48940 Leioa
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33100 Udine
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60323 Frankfurt Am Main
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CR6 9LD Warlingham
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
00153 Roma
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