Training the next-generation of European GLIOblastoma (translational) researchers, to RESOLVE precision targeting of the brain tumour microenvironment

Información del proyecto

GLIORESOLVE

Identificador del acuerdo de subvención: 101073386

DOI

10.3030/101073386

Proyecto cerrado

Fecha de la firma de la CE 6 Julio 2022

Fecha de inicio 1 Septiembre 2022

Fecha de finalización 31 Agosto 2026

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 2 672 925,60

Coordinado por

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Website, Twitter, Facebook Page

Website, Twitter, Facebook Page.

Other (1)

DR vacancies advertised

DR vacancies advertised.

Documents, reports (1)

Dissemination and public engagement reports 1

Dissemination & public engagement reports (events, talks, publications, posters, public engagement).

Publicaciones

Peer reviewed articles (13)

Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors

Autores: Biswas, Archita; Salvucci, Manuela; Connor, Kate; Dussmann, Heiko; Carberry, Steven; Fichtner, Michael; King, Ellen; Murphy, Brona; O'Farrell, Alice C.; Cryan, Jane; Beausang, Alan; Heffernan, Josephine; Cremona, Mattia; Hennessy, Bryan T.; Clerkin, James; Sweeney, Kieron J.; MacNally, Steve; Brett, Francesca; O'Halloran, Philip; Bacon, Orna; Furney, Simon; Verreault, Maite; Quissac, Emie; Bielle, Franck; Ahmed, Mohammed H.; Idbaih, Ahmed; Leenstra, Sieger; Ntafoulis, Ioannis; Fabro, Federica; Lamfers, Martine; Golebiewska, Anna; Hertel, Frank; Niclou, Simone P.; Yen, Romain Tching Chi; Kremer, Andreas; Dilcan, Gonca; Lodi, Francesca; Arijs, Ingrid; Lambrechts, Diether; Purushothama, Manasa Kalya; Kel, Alexander; Byrne, Annette T.; Prehn, Jochen H.M.
Publicado en: Journal of Neuro-Oncology, Edición 163, 2023
Editor: Springer
DOI: 10.21203/RS.3.RS-2831912/V1

Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow

Autores: Jade Admiraal, Promise O. Emeh, Marleen Bokkers, Sander P. M. de Ruiter, Thomas Olivier, Karla Queiroz, Todd P. Burton, Nienke R. Wevers
Publicado en: Fluids and Barriers of the CNS, Edición 23, 2026, ISSN 2045-8118
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00765-X

Advanced 3D patient-derived glioblastoma organoid-immune cell co-cultures reveal preserved MHC-I tumor cell surface expression and tumor cell-driven T-cell dysfunction

Autores: Mahsa Rezaeipour, Marta de Lucas Sanz, Hamed Allahverdi, Gaëlle Triballier, Eliane Klein, Ilaria Salvato, Pilar M. Moreno-Sanchez, Bakhtiyor Nosirov, Petr V. Nazarov, Batuhan Kisakol, Heiko Dussmann, Colum Connolly, Annette T. Byrne, Jochen H.M. Prehn, Dirk Brenner, Bassam Janji, Simone P. Niclou, Anna Golebiewska
Publicado en: Journal of Neuroinflammation, 2026, ISSN 1742-2094
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12974-026-04048-Y

The ins and outs of microglial cells in brain health and disease

Autores: Pallares-Moratalla, Carla; Bergers, Gabriele
Publicado en: Frontiers in Immunology, Edición 15, 2024, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/FIMMU.2024.1305087

Transcriptome fingerprinting of aberrant fibroblast activation unlocks effective therapeutics to tackle cardiac fibrosis

Autores: Mathieu Cinato, Ryeonshi Kang, Solomiia Kramar, Lesia Savchenko, Nathalie Pizzinat, Audrey Swiader, Alexander Kel, Aleksandr Kalmykov, Daria Stelmashenko, Ilenia Martinelli, Jerome Roncalli, Charlotte Laborde, Oksana Kunduzova
Publicado en: Science Advances, Edición 11, 2025, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADX0968

The Pan-Tumor Vasculature under the Transcriptomic Magnifying Glass

Autores: Krish Skandha Gopalan, Gabriele Bergers
Publicado en: Cancer Research, Edición 84, 2024, ISSN 0008-5472
Editor: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-24-3219

OBSERVE: guidelines for the refinement of rodent cancer models

Autores: Stéphanie I. De Vleeschauwer; Marieke van de Ven; Anaïs Oudin; Karlijn Debusschere; Kate Connor; Annette T. Byrne; Doreen Ram; Anne Marie Rhebergen; Yannick D. Raeves; Maik Dahlhoff; Virginie Dangles-Marie; Els R. Hermans
Publicado en: Nature Protocols, Edición 19, 2024, ISSN 1750-2799
Editor: Springer Nature
DOI: 10.1038/s41596-024-00998-w

Modelling brain tumours with organoids: towards precision medicine in neuro-oncology

Autores: Marta de Lucas Sanz, Simone P. Niclou, Anna Golebiewska
Publicado en: Nature Reviews Neurology, 2026, ISSN 1759-4758
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41582-026-01190-2

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity

Autores: Pilar M. Moreno-Sanchez, Mahsa Rezaeipour, Else Marit Inderberg, Michael Platten, Anna Golebiewska
Publicado en: Nature Cancer, Edición 7, 2026, ISSN 2662-1347
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S43018-025-01097-9

Type I interferon drives T cell responses to amyloid beta in the central nervous system

Autores: Julius J. Michel, Khwab Sanghvi, Jakob Rosenbauer, Lea Humbs, Clara Tejido Dierssen, Saskia Grudzenski-Theis, Viktoria Sachs, Kristine Jähne, Karoline Degenhardt, Lutz Frölich, Jochen Herms, Marc Fatar, Michael Platten, Lukas Bunse
Publicado en: Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-72262-6

Challenging the status quo to improve the translational potential of preclinical oncology studies

Autores: Kate Connor; Anna Golebiewska; Annette T. Byrne
Publicado en: Nature Reviews Cancer, Edición 25, 2024, ISSN 1474-1768
Editor: Nature Publishing
DOI: 10.1038/S41568-024-00756-W

Evaluating the NFPp10a/NF5310 glioblastoma model as a faithful avatar for screening tumour microenvironment–targeted therapies

Autores: Kieron White, James Clerkin, Liam P. Shiels, Kieron Sweeney, Mohannad Dabbour, Alice C. O’Farrell, Maïté Verreault, Thomas Van Brussel, Ingrid Arijs, Suzanne Murphy, Evin M. Haworth, Christopher Van Hessche, Gautam Shankar, Joana Beyer, Patrick Dicker, Stephen G. Maher, Laure Marignol, Jack P. Gleeson, David O’Brien, Diether Lambrechts, Jochen H. M. Prehn, Ahmed Idbaih, Frederik De Smet, null null, Martine L. M. Lamfers, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Johan M. Kros, Franck Bielle, Emie Quissac, Francesca Lodi, Gonca Dilcan, Archita Biswas, Manuela Salvucci, Jane Cryan, Francesca Brett, Alan Beausang, Steve MacNally, Philip J. O’Halloran, Orna Bacon, Kate Connor, Annette T. Byrne
Publicado en: Communications Biology, 2026, ISSN 2399-3642
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S42003-026-10874-W

Distinct tumor immune microenvironmental landscapes drive divergent immunotherapy responses in glioblastoma

Autores: Linqian Weng, Krish Skandha Gopalan, Mélanie Guyot, Maxime Vanmechelen, Pouya Nazari, Marie Duhamel, Clelia Donisi, Carla Pallarés-Moratalla, Abhishek D Garg, Kieron White, Annette T Byrne, Diether Lambrechts, Frederik De Smet, Gabriele Bergers
Publicado en: Neuro-Oncology, 2026, ISSN 1522-8517
Editor: Oxford University Press (OUP)
DOI: 10.1093/NEUONC/NOAG018