Training the next-generation of European GLIOblastoma (translational) researchers, to RESOLVE precision targeting of the brain tumour microenvironment

Informazioni relative al progetto

GLIORESOLVE

ID dell’accordo di sovvenzione: 101073386

DOI

10.3030/101073386

Progetto chiuso

Data della firma CE 6 Luglio 2022

Data di avvio 1 Settembre 2022

Data di completamento 31 Agosto 2026

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 2 672 925,60

Coordinato da

ROYAL COLLEGE OF SURGEONS IN IRELAND
Ireland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Website, Twitter, Facebook Page

Website, Twitter, Facebook Page.

Other (1)

DR vacancies advertised

DR vacancies advertised.

Documents, reports (1)

Dissemination and public engagement reports 1

Dissemination & public engagement reports (events, talks, publications, posters, public engagement).

Pubblicazioni

Peer reviewed articles (13)

Comparative analysis of deeply phenotyped GBM cohorts of ‘short-term’ and ‘long-term’ survivors

Autori: Biswas, Archita; Salvucci, Manuela; Connor, Kate; Dussmann, Heiko; Carberry, Steven; Fichtner, Michael; King, Ellen; Murphy, Brona; O'Farrell, Alice C.; Cryan, Jane; Beausang, Alan; Heffernan, Josephine; Cremona, Mattia; Hennessy, Bryan T.; Clerkin, James; Sweeney, Kieron J.; MacNally, Steve; Brett, Francesca; O'Halloran, Philip; Bacon, Orna; Furney, Simon; Verreault, Maite; Quissac, Emie; Bielle, Franck; Ahmed, Mohammed H.; Idbaih, Ahmed; Leenstra, Sieger; Ntafoulis, Ioannis; Fabro, Federica; Lamfers, Martine; Golebiewska, Anna; Hertel, Frank; Niclou, Simone P.; Yen, Romain Tching Chi; Kremer, Andreas; Dilcan, Gonca; Lodi, Francesca; Arijs, Ingrid; Lambrechts, Diether; Purushothama, Manasa Kalya; Kel, Alexander; Byrne, Annette T.; Prehn, Jochen H.M.
Pubblicato in: Journal of Neuro-Oncology, Numero 163, 2023
Editore: Springer
DOI: 10.21203/RS.3.RS-2831912/V1

Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow

Autori: Jade Admiraal, Promise O. Emeh, Marleen Bokkers, Sander P. M. de Ruiter, Thomas Olivier, Karla Queiroz, Todd P. Burton, Nienke R. Wevers
Pubblicato in: Fluids and Barriers of the CNS, Numero 23, 2026, ISSN 2045-8118
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12987-026-00765-X

Advanced 3D patient-derived glioblastoma organoid-immune cell co-cultures reveal preserved MHC-I tumor cell surface expression and tumor cell-driven T-cell dysfunction

Autori: Mahsa Rezaeipour, Marta de Lucas Sanz, Hamed Allahverdi, Gaëlle Triballier, Eliane Klein, Ilaria Salvato, Pilar M. Moreno-Sanchez, Bakhtiyor Nosirov, Petr V. Nazarov, Batuhan Kisakol, Heiko Dussmann, Colum Connolly, Annette T. Byrne, Jochen H.M. Prehn, Dirk Brenner, Bassam Janji, Simone P. Niclou, Anna Golebiewska
Pubblicato in: Journal of Neuroinflammation, 2026, ISSN 1742-2094
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12974-026-04048-Y

The ins and outs of microglial cells in brain health and disease

Autori: Pallares-Moratalla, Carla; Bergers, Gabriele
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/FIMMU.2024.1305087

Transcriptome fingerprinting of aberrant fibroblast activation unlocks effective therapeutics to tackle cardiac fibrosis

Autori: Mathieu Cinato, Ryeonshi Kang, Solomiia Kramar, Lesia Savchenko, Nathalie Pizzinat, Audrey Swiader, Alexander Kel, Aleksandr Kalmykov, Daria Stelmashenko, Ilenia Martinelli, Jerome Roncalli, Charlotte Laborde, Oksana Kunduzova
Pubblicato in: Science Advances, Numero 11, 2025, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADX0968

The Pan-Tumor Vasculature under the Transcriptomic Magnifying Glass

Autori: Krish Skandha Gopalan, Gabriele Bergers
Pubblicato in: Cancer Research, Numero 84, 2024, ISSN 0008-5472
Editore: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-24-3219

OBSERVE: guidelines for the refinement of rodent cancer models

Autori: Stéphanie I. De Vleeschauwer; Marieke van de Ven; Anaïs Oudin; Karlijn Debusschere; Kate Connor; Annette T. Byrne; Doreen Ram; Anne Marie Rhebergen; Yannick D. Raeves; Maik Dahlhoff; Virginie Dangles-Marie; Els R. Hermans
Pubblicato in: Nature Protocols, Numero 19, 2024, ISSN 1750-2799
Editore: Springer Nature
DOI: 10.1038/s41596-024-00998-w

Modelling brain tumours with organoids: towards precision medicine in neuro-oncology

Autori: Marta de Lucas Sanz, Simone P. Niclou, Anna Golebiewska
Pubblicato in: Nature Reviews Neurology, 2026, ISSN 1759-4758
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41582-026-01190-2

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity

Autori: Pilar M. Moreno-Sanchez, Mahsa Rezaeipour, Else Marit Inderberg, Michael Platten, Anna Golebiewska
Pubblicato in: Nature Cancer, Numero 7, 2026, ISSN 2662-1347
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S43018-025-01097-9

Type I interferon drives T cell responses to amyloid beta in the central nervous system

Autori: Julius J. Michel, Khwab Sanghvi, Jakob Rosenbauer, Lea Humbs, Clara Tejido Dierssen, Saskia Grudzenski-Theis, Viktoria Sachs, Kristine Jähne, Karoline Degenhardt, Lutz Frölich, Jochen Herms, Marc Fatar, Michael Platten, Lukas Bunse
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-72262-6

Challenging the status quo to improve the translational potential of preclinical oncology studies

Autori: Kate Connor; Anna Golebiewska; Annette T. Byrne
Pubblicato in: Nature Reviews Cancer, Numero 25, 2024, ISSN 1474-1768
Editore: Nature Publishing
DOI: 10.1038/S41568-024-00756-W

Evaluating the NFPp10a/NF5310 glioblastoma model as a faithful avatar for screening tumour microenvironment–targeted therapies

Autori: Kieron White, James Clerkin, Liam P. Shiels, Kieron Sweeney, Mohannad Dabbour, Alice C. O’Farrell, Maïté Verreault, Thomas Van Brussel, Ingrid Arijs, Suzanne Murphy, Evin M. Haworth, Christopher Van Hessche, Gautam Shankar, Joana Beyer, Patrick Dicker, Stephen G. Maher, Laure Marignol, Jack P. Gleeson, David O’Brien, Diether Lambrechts, Jochen H. M. Prehn, Ahmed Idbaih, Frederik De Smet, null null, Martine L. M. Lamfers, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Johan M. Kros, Franck Bielle, Emie Quissac, Francesca Lodi, Gonca Dilcan, Archita Biswas, Manuela Salvucci, Jane Cryan, Francesca Brett, Alan Beausang, Steve MacNally, Philip J. O’Halloran, Orna Bacon, Kate Connor, Annette T. Byrne
Pubblicato in: Communications Biology, 2026, ISSN 2399-3642
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S42003-026-10874-W

Distinct tumor immune microenvironmental landscapes drive divergent immunotherapy responses in glioblastoma

Autori: Linqian Weng, Krish Skandha Gopalan, Mélanie Guyot, Maxime Vanmechelen, Pouya Nazari, Marie Duhamel, Clelia Donisi, Carla Pallarés-Moratalla, Abhishek D Garg, Kieron White, Annette T Byrne, Diether Lambrechts, Frederik De Smet, Gabriele Bergers
Pubblicato in: Neuro-Oncology, 2026, ISSN 1522-8517
Editore: Oxford University Press (OUP)
DOI: 10.1093/NEUONC/NOAG018