Objective
The pharmaceutical, chemical and polymer industries are cornerstones of Europe’s economy. A key element for their
transition to more sustainable processes and to innovative new compounds is biocatalysis.
Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and
radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine
the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site.
To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across
leading European universities that will train the next generation of scientists capable of tackling the design, development and
implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists,
bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal
point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage
modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in
the needs of industrial biotechnology, the consortium includes eight of Europe´s leading pharmaceutical, chemical and
enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training
partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and
the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs
will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS´s
creativity and result in a an unique form of science dialogue with the general public.
Fields of science
- engineering and technologyindustrial biotechnology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- natural scienceschemical sciencespolymer sciences
- natural scienceschemical sciencescatalysisbiocatalysis
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
64289 Darmstadt
Germany
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Participants (6)
9712CP Groningen
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67081 Strasbourg
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1180 Wien
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20122 Milano
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70174 Stuttgart
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44227 Dortmund
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Partners (18)
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4051 Basel
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8092 Zuerich
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3012 Bern
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2880 Bagsvaerd
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64673 Zwingenberg
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EC4A 4AB London
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67063 Ludwigshafen Am Rhein
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4056 Basel
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OX9 3EZ Thame
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67400 Illkirch Graffenstaden
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77920 Samois Sur Seine
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79100 Freiburg
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3311 GX Dordrecht
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1030 Wien
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Lamone
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M13 9PL Manchester
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52428 Julich
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G1 1XQ Glasgow
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