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Metal-containing Radical Enzymes

Objectif

The pharmaceutical, chemical and polymer industries are cornerstones of Europe’s economy. A key element for their
transition to more sustainable processes and to innovative new compounds is biocatalysis.
Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and
radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine
the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site.
To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across
leading European universities that will train the next generation of scientists capable of tackling the design, development and
implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists,
bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal
point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage
modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in
the needs of industrial biotechnology, the consortium includes eight of Europe´s leading pharmaceutical, chemical and
enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training
partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and
the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs
will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS´s
creativity and result in a an unique form of science dialogue with the general public.

Coordinateur

TECHNISCHE UNIVERSITAT DARMSTADT
Contribution nette de l'UE
€ 434 232,00
Adresse
KAROLINENPLATZ 5
64289 Darmstadt
Allemagne

Voir sur la carte

Région
Hessen Darmstadt Darmstadt, Kreisfreie Stadt
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée

Participants (6)

Partenaires (18)