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Neural basis of zebrafish collective decision-making

Project description

Collective decision-making in zebrafish: behavioural algorithms and neural mechanisms

People are not the only animals to make collective decisions that impact outcomes for the whole. Such decision-making is witnessed in swarming honeybees, flocks of birds and shoals of fish. However, little is known about how they do this. The European Research Council-funded CollectiveDecisions project will harness the well-characterised, experimentally accessible and cognitively active juvenile zebrafish as a model system in which to study the neural basis of collective decision-making in animals. The study will include closed-loop virtual reality experiments, measurements of brain activity in restrained and freely swimming fish, and targeted laser ablation and optogenetic activation to link neural circuit function to group decision-making performance.

Objective

It is challenging for isolated animals to reliably extract and integrate behaviorally relevant information from the natural environment. Due to the limited sensory capacity of individuals, many animal species therefore share and evaluate cues collectively, allowing them to solve complex decision-making tasks as a group. The behavioral algorithms and neural mechanisms that give rise to these cognitive abilities remain poorly understood. In many fish species, these behaviors are largely vision-based, providing the opportunity to decipher the underlying general computational principles under well-controlled experimental conditions in the lab. At the same time, it is becoming possible to employ powerful neuroscientific techniques, enabling new detailed analyses of the neural circuitry that orchestrates behavior. I propose to establish the juvenile zebrafish as a model system that is optimally suited for the study of collective decision-making. At this intermediate developmental stage, zebrafish offer an excellent compromise between cognitive ability and experimental accessibility. They can temporally and spatially integrate information, they start to socially interact, and one can characterize and manipulate brain activity in intact behaving animals. Using closed-loop virtual reality experiments, I will initially dissect the algorithmic rules by which juvenile zebrafish make decisions when swimming in heterogeneously biased groups. I will then characterize brain activity related to this behavior, in freely swimming fish, and in restrained preparations. Finally, to causally link neural circuit function and group decision-making performance, I will carry out targeted laser ablation and optogenetic activation experiments. Thus, my proposed research in juvenile zebrafish will, for the first time, provide key insights into the behavioral algorithms and neural mechanisms of how individual animals and animal collectives acquire sensory information and make complex decisions.

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HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

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(opens in new window) ERC-2022-STG

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Host institution

UNIVERSITAT KONSTANZ
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 498 787,00
Address
UNIVERSITATSSTRASSE 10
78464 Konstanz
Germany

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Region
Baden-Württemberg Freiburg Konstanz
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 498 787,00

Beneficiaries (1)

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