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Smart Cardiac Magnetic Resonance Delivering One-Click and Comprehensive Assessment of Cardiovascular Diseases

Project description

Advanced imaging for cardiovascular disease diagnosis

Cardiovascular diseases (CVD) are a leading cause of death worldwide, posing a significant health challenge that demands attention and innovative approaches to prevention, diagnosis, and treatment. However, current methods for assessing the heart’s function and structure, such as cardiac magnetic resonance imaging (CMR), have limitations that hinder their widespread adoption. Funded by the European Research Council, the SMHEART project aims to revolutionise CMR by developing a fast, automated imaging pipeline that allows for comprehensive and efficient diagnosis, prognosis, and therapy selection in cardiology. This transformative technology aims to maximise the impact of CMR and streamline its use, paving the way for personalised patient care in cardiovascular health.

Objective

Cardiovascular disease (CVD) causes at least 1.8 million European deaths annually, exceeding fatalities from cancer, chronic respiratory disease, and diabetes. Consequently, the fight against CVD has become the main priority of the World Health Organization.

In the pursuit of understanding and treating CVD, cardiac magnetic resonance imaging (CMR) has remained the only modality capable of providing a comprehensive assessment of the hearts function and structure without harmful radiation. Unfortunately, current CMR systems remain too slow, too complex, require highly trained specialists and, as such, have presented a barrier to a wider adoption of CMR.

The aim of my ERC project is to unleash the full potential of CMR to transform patient trajectories by introducing a fast, one-click, fully automated, and comprehensive imaging pipeline applicable to diagnosis, prognosis, and therapy selection in cardiology.

This aim will be achieved by (i) creating a novel imaging technology that collects CMR data in a single continuous free-breathing scan, taking into account post-processing requirements at the very origin of CMR sequence design; (ii) exploiting the unique contrasts generated by this technology to automatically extract quantitative markers on cardiac anatomy, function, and tissue characteristics; and (iii) translating this transformative technology from a pre-clinical to a clinical setting.

This will be the first-ever integrated cardiac imaging pipeline in which CMR images are acquired in a single click, jointly represented in a single volume, and automatically analysed. This will unlock obstacles for broader acceptance of CMR and unleash the full potential of CMR to maximize its impact on patient trajectories. The results of this project will pave the way towards robust image-based strategies for personalized patient care (diagnosis, risk stratification, therapy selection, monitoring, and image-guided interventions).

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Topic(s)

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Funding Scheme

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HORIZON-ERC - HORIZON ERC Grants

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Call for proposal

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(opens in new window) ERC-2022-STG

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Host institution

UNIVERSITE DE BORDEAUX
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 415 375,00
Address
PLACE PEY BERLAND 35
33000 BORDEAUX
France

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 498 529,00

Beneficiaries (2)

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