CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
A detailed protocol on application of innovative technology IMC on tumor organoids will be created to uncover molecular changes at protein and single-cell level in tumor microenvironment after treatments. The protocol will be conducted by exchange of best practices and scientific knowledge within consortium. Protocol will be written, revised by partners of consortium, and available for consortium partners.
Guidelines - Reaching excellence in project management (se abrirá en una nueva ventana)The guidelines will be produced for internal and external use by interested members of the public, identifying best practices for specific phases of project management and developing them further in the form of recommendations and guidelines to achieve and maintain project management excellence.
Report on the research trainings and expert exchange (se abrirá en una nueva ventana)Reports on the research trainings and expert exchange conducted under WP5 will be consistent with Dissemination/twinning/networking activities of the project and will include explanations for any discrepancies. Reports shall include description of all activities within research trainings and expert visits including meetings between partner´ staff, exchange of know-how, hands-on training of researchers, summer schools and workshops.
Progress Report (se abrirá en una nueva ventana)The progress report as a deliverable at Month 17, will be the basis for the interim review meeting.
A protocol for application of ISS on tumour organoids (se abrirá en una nueva ventana)A detailed protocol on application of state-of-the art methodology ISS on tumor organoids will be created to uncover molecular changes at gene level in tumor microenvironment after treatments. The protocol will be conducted by exchange of best practices and scientific knowledge within consortium. Protocol will be written, revised by partners of consortium, and available for consortium partners.
Scientific publications (se abrirá en una nueva ventana)Peer-reviewed scientific publications: Dissemination of project results to the international scientific community will be accomplished through publication of results (2-4 papers ) in high impact scientific journals in the scope of Toxicology, Cancer Research, Oncology, etc. Unless there are specific reasons not to do so, only the Open Access format will be chosen, allowing unrestricted access to the scientific and technical results.
Research strategy: NIB: Access to Excellence and presentation of best practices (se abrirá en una nueva ventana)In addition to monitoring progress and incorporating lessons learned, the draft strategy will include identifying future collaborations and discussing potential future pathways based on an analysis of SWOT and considering each partner's strategies. By learning from each other, we aim to become better, more recognisable, more social, and explore innovative approaches to increase the visibility and accessibility of cutting-edge research. Particular attention will be paid to shaping the consortium's funding portfolio over the life of the project and beyond, seeking, learning, and implementing synergies at multiple levels. Scientific gaps will be considered first, before gaps in support infrastructure are considered.
A protocol for the assessment of genomic instability in hepatic and lung 3D cell models (se abrirá en una nueva ventana)A detail protocol for the assessment of genomic instability in hepatic and lung 3D cell models will be prepared as a guideline for testing genotoxic activity of chemicals and nanoparticles. The protocol will contain all the necessary steps and information for the successful performance of the cytokinesis block micronucleus (CBMN) assay on hepatic and lung 3D cell models.
A guideline protocol for big data management (se abrirá en una nueva ventana)Using advanced platforms for high-throughput analysis such as Metafer and FlowSight, as well as spatial technologies and single-cell analysis, a significant amount of raw data, high-resolution images, and (meta-)data are generated, consuming large amounts of digital storage, thus requiring highly efficient tools for Big Data management. It also generates sensitive patient-related and scientific data. By sharing knowledge and best practices on data management and storage, protocols and documents with partner institutions and expert visits from SWAN, SU and VUmc to NIB, NIB will learn how to handle Big Data management and protect sensitive data through protected internal and external data storage options that ensure secure data storage and analysis. The expert exchange will establish general policy protocols that describe procedures and criteria for optimal data management and storage.
A protocol for the use of advanced platforms for high-throughput analysis of (geno)toxicological outcomes (se abrirá en una nueva ventana)A detail protocol how to use advanced platforms (e.g., MetaferTM system from MetaSystems and FlowSight imaging cytometry platform from Amnis) for medium and high-throughput automated analysis will be prepared as a guideline for testing genotoxic activity of chemicals and nanoparticles. The protocol will contain all the necessary steps and information how to use advanced platforms for the evaluation of genotoxic activity of chemicals and nanoparticles.
The final report on dissemination, exploitation and communication activities must be consistent with the DMP (Deliverable 2.1) and include explanations for any discrepancies. The final report shall include all communication and dissemination activities, including samples, and shall represent the activities of each partner and the consortium. A communication, dissemination, and exploitation protocol will be provided at the kick-off event at the beginning of the project and will be consistent with the grant and consortium agreement.
Publicaciones
Autores:
Jure Povšin, Timotej Sotošek, Metka Novak, Barbara Breznik
Publicado en:
Slovenian Veterinary Research, Edición 62, 2025, ISSN 2385-8761
Editor:
University of Ljubljana
DOI:
10.26873/SVR-2029-2024
Autores:
Urban Bogataj, Metka Novak, Simona Katrin Galun, Klementina Fon Tacer, Milos Vittori, Cornelis J.F. Van Noorden, Barbara Breznik
Publicado en:
Radiology and Oncology, Edición 59, 2025, ISSN 1581-3207
Editor:
Walter de Gruyter GmbH
DOI:
10.2478/RAON-2025-0056
Autores:
Martina Štampar, Bojana Žegura
Publicado en:
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Edición 900, 2025, ISSN 1383-5718
Editor:
Elsevier BV
DOI:
10.1016/J.MRGENTOX.2024.503835
Autores:
Iza Rozman, Alvaro Gallo-Cordova, María del Puerto Morales, Marco A. Morales Ovalle, Gerardo F. Goya, Katja Kološa, Domen Hočevar, Bojana Žegura, Alja Štern
Publicado en:
Biomedicine & Pharmacotherapy, Edición 195, 2026, ISSN 0753-3322
Editor:
Elsevier BV
DOI:
10.1016/J.BIOPHA.2025.118950
Autores:
Ezgi B Ulas, Sofie J I Koomen, Anne Vrijmoet, Ilias Houda, H Ibrahim Korkmaz, Chris Dickhoff, Idris Bahce, Suresh Senan, Tanja D de Gruijl, Marieke F Fransen, Teodora Radonic, Febe van Maldegem, Famke L Schneiders
Publicado en:
Journal for ImmunoTherapy of Cancer, Edición 13, 2025, ISSN 2051-1426
Editor:
BMJ
DOI:
10.1136/JITC-2025-013237
Autores:
Metka Novak, Bernarda Majc, Marta Malavolta, Andrej Porčnik, Jernej Mlakar, Matjaž Hren, Anamarija Habič, Mateja Mlinar, Ivana Jovčevska, Neja Šamec, Alja Zottel, Marija Skoblar Vidmar, Tina Vipotnik Vesnaver, Andrej Zupan, Alenka Matjašič, Saša Trkov Bobnar, Dejan Georgiev, Aleksander Sadikov, Roman Bošnjak, Borut Prestor, Radovan Komel, Tamara Lah Turnšek, Barbara Breznik
Publicado en:
Neuro-Oncology Advances, Edición 7, 2025, ISSN 2632-2498
Editor:
Oxford University Press (OUP)
DOI:
10.1093/NOAJNL/VDAF015
Autores:
Irma Durmišević, Anja Haverić, Sonja Žabkar, Alja Štern, Katja Kološa, Petra Jenuš Belec, Tamara Ćetković Pećar, Maida Hadžić Omanović, Sanjin Gutić, Iza Rozman, Sanin Haverić, Bojana Žegura
Publicado en:
Archives of Toxicology, 2026, ISSN 0340-5761
Editor:
Springer Science and Business Media LLC
DOI:
10.1007/S00204-026-04336-9
Autores:
Megan Cole, Panayiotis Anastasiou, Claudia Lee, Xiaofei Yu, Andrea de Castro, Jannes Roelink, Chris Moore, Edurne Mugarza, Martin Jones, Karishma Valand, Sareena Rana, Emma Colliver, Mihaela Angelova, Katey S. S. Enfield, Alastair Magness, Asher Mullokandov, Gavin Kelly, Tanja D. de Gruijl, Miriam Molina-Arcas, Charles Swanton, Julian Downward, Febe van Maldegem
Publicado en:
Science Advances, Edición 10, 2024, ISSN 2375-2548
Editor:
American Association for the Advancement of Science (AAAS)
DOI:
10.1126/SCIADV.ADL6464
Autores:
Emanuela Senjor, Anamarija Habič, Urban Švajger, Ana Mitrović, Matic Proj, Andrej Porčnik, Borut Prestor, Miha Jerala, Matic Bošnjak, Stanislav Gobec, Barbara Breznik, Janko Kos, Milica Perišić Nanut
Publicado en:
Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor:
Frontiers Media SA
DOI:
10.3389/FIMMU.2025.1708281
Autores:
Sendra Marta; Štampar Martina; Fras Katarina; Novoa Beatriz; Figueras Antonio; Žegura Bojana
Publicado en:
Environment International, Edición Volume 171, January 2023, 107721, 2023, ISSN 0160-4120
Editor:
New York : Elsevier, 1978
DOI:
10.1016/J.ENVINT.2022.107721
Autores:
Rebecca R. J. Collins, Rebecca R. Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K. Lee, Samuel T. Peters, Jon P. Connelly, Shondra M. Pruett-Miller, Martine F. Roussel, Dinesh Rakheja, Heather S. Tillman, Patrick Ryan Potts, Klementina Fon Tacer
Publicado en:
Acta Neuropathologica Communications, Edición 13, 2025, ISSN 2051-5960
Editor:
Springer Science and Business Media LLC
DOI:
10.1186/S40478-025-02055-3
Autores:
Enfield KSS, Colliver E, Lee CSY, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A, Consortium T, Jamal-Han
Publicado en:
Cancer Discovery, Edición 2024 Jun 3; 14(6): 1018–1047, 2024, ISSN 2159-8290
Editor:
American Association for Cancer Research
DOI:
10.1158/2159-8290.CD-23-1380
Autores:
Štampar Martina; Ravnjak Tim; Domijan Ana-Marija; Žegura Bojana
Publicado en:
Molecules, Edición Vol 28, Iss 7, p 3085 (2023), 2023, ISSN 1420-3049
Editor:
MDPI
DOI:
10.3390/MOLECULES28073085
Autores:
Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak
Publicado en:
iScience, Edición 27, 2025, ISSN 2589-0042
Editor:
Elsevier BV
DOI:
10.1016/J.ISCI.2024.110604
Autores:
Vesna Kokondoska Grgič, Nika Marolt, Ajla Kubat, Tamara Dokmanović, Katja Kološa, Ivana Jovčevska, Tea Lanišnik Rižner
Publicado en:
Biomedicine & Pharmacotherapy, Edición 195, 2026, ISSN 0753-3322
Editor:
Elsevier BV
DOI:
10.1016/J.BIOPHA.2026.119010
Autores:
Anja Blazic, Bernarda Majc, Metka Novak, Barbara Breznik, Lea Rems
Publicado en:
Radiology and Oncology, Edición 59, 2025, ISSN 1581-3207
Editor:
Walter de Gruyter GmbH
DOI:
10.2478/RAON-2025-0058
Autores:
Alja Štern, Katja Kološa, Špela Rozman, Bojana Žegura
Publicado en:
Science of The Total Environment, Edición 1001, 2025, ISSN 0048-9697
Editor:
Elsevier BV
DOI:
10.1016/J.SCITOTENV.2025.180527
Autores:
Hooman Taleban, Xinzhong Li, Zulfiqur Ali, Karunakaran Kalesh, Jai Prakash, Tugba Bagci-Onder, Barbara Breznik
Publicado en:
Frontiers in Bioengineering and Biotechnology, Edición 13, 2026, ISSN 2296-4185
Editor:
Frontiers Media SA
DOI:
10.3389/FBIOE.2025.1716813
Autores:
Alja Zottel; Metka Novak; Neja Šamec; Bernarda Majc; Sara Colja; Mojca Katrašnik; Miloš Vittori; Barbara Hrastar; Ana Rotter; Andrej Porčnik; Tamara Lah Turnšek; Radovan Komel; Barbara Breznik; Ivana Jovčevska
Publicado en:
Cancers, Edición Volume 15, Edición 573 (2023), 2023, ISSN 2072-6694
Editor:
MDPI
DOI:
10.3390/CANCERS15030573
Autores:
Alja Štern; Matjaž Novak; Katja Kološa; Jurij Trontelj; Sonja Žabkar; Tjaša Šentjurc; Metka Filipič; Bojana Žegura
Publicado en:
Biomedicine & Pharmacotherapy, 2024, ISSN 1950-6007
Editor:
Elsevier
DOI:
10.1016/J.BIOPHA.2024.116969
Autores:
Sanz-Sagué B, Sáenz-Hernández A, Moreno Maldonado AC, Fuentes-García JA, Nuñez JM, Zegura B, Stern A, Kolosa K, Rozman I, Torres TE, Goya GF
Publicado en:
Chemico-Biological Interactions, Edición Volume 394, 1 May 2024, 110977, 2024, ISSN 0009-2797
Editor:
Elsevier B.V.
DOI:
10.1016/J.CBI.2024.110977
Autores:
Gillian E Conway, Bérénice Chavanel, François Virard, Ume-Kulsoom Shah, Michael J Burgum, Stephen J Evans, Michael Korenjak, Laura E Thomas, Gareth J Jenkins, Jiri Zavadil, Shareen H Doak
Publicado en:
Mutagenesis, 2025, ISSN 0267-8357
Editor:
Oxford University Press (OUP)
DOI:
10.1093/MUTAGE/GEAF015
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