TWINNING FOR EXCELLENCE TO STRATEGICALLY ADVANCE RESEARCH IN CARCINOGENESIS AND CANCER

Información del proyecto

CutCancer

Identificador del acuerdo de subvención: 101079113

DOI

10.3030/101079113

Proyecto cerrado

Fecha de la firma de la CE 1 Agosto 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 197 550,00

Aportación de la UE

€ 1 197 550,00

Coordinado por

NACIONALNI INSTITUT ZA BIOLOGIJO
Slovenia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (2)

Progress Report

The progress report as a deliverable at Month 17, will be the basis for the interim review meeting.

A protocol for the assessment of genomic instability in hepatic and lung 3D cell models

A detail protocol for the assessment of genomic instability in hepatic and lung 3D cell models will be prepared as a guideline for testing genotoxic activity of chemicals and nanoparticles. The protocol will contain all the necessary steps and information for the successful performance of the cytokinesis block micronucleus (CBMN) assay on hepatic and lung 3D cell models.

Publicaciones

Peer reviewed articles (21)

GUT MICROBIOME IN CANCER: THE NEXT BIG OPPORTUNITY FOR BETTER PATIENT OUTCOMES?

Autores: Jure Povšin, Timotej Sotošek, Metka Novak, Barbara Breznik
Publicado en: Slovenian Veterinary Research, Edición 62, 2025, ISSN 2385-8761
Editor: University of Ljubljana
DOI: 10.26873/SVR-2029-2024

Heterogenous mitochondrial ultrastructure and metabolism of human glioblastoma cells: differences between stem-like and differentiated cancer cells in response to chemotherapy

Autores: Urban Bogataj, Metka Novak, Simona Katrin Galun, Klementina Fon Tacer, Milos Vittori, Cornelis J.F. Van Noorden, Barbara Breznik
Publicado en: Radiology and Oncology, Edición 59, 2025, ISSN 1581-3207
Editor: Walter de Gruyter GmbH
DOI: 10.2478/RAON-2025-0056

In vitro hepatic 3D cell models and their application in genetic toxicology: A systematic review

Autores: Martina Štampar, Bojana Žegura
Publicado en: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Edición 900, 2025, ISSN 1383-5718
Editor: Elsevier BV
DOI: 10.1016/J.MRGENTOX.2024.503835

Safety of ferrite nanoparticles for biomedical applications: Cyto- and genotoxic effects of MxFe3-xO4 (M = Fe, Zn, Mn) in an Advanced 3D human hepatic in vitro model

Autores: Iza Rozman, Alvaro Gallo-Cordova, María del Puerto Morales, Marco A. Morales Ovalle, Gerardo F. Goya, Katja Kološa, Domen Hočevar, Bojana Žegura, Alja Štern
Publicado en: Biomedicine & Pharmacotherapy, Edición 195, 2026, ISSN 0753-3322
Editor: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.118950

Immune-modulating effects on tumor-draining lymph nodes of neoadjuvant chemoradiotherapy combined with dual immunotherapy in patients with T3-4N0-2 NSCLC

Autores: Ezgi B Ulas, Sofie J I Koomen, Anne Vrijmoet, Ilias Houda, H Ibrahim Korkmaz, Chris Dickhoff, Idris Bahce, Suresh Senan, Tanja D de Gruijl, Marieke F Fransen, Teodora Radonic, Febe van Maldegem, Famke L Schneiders
Publicado en: Journal for ImmunoTherapy of Cancer, Edición 13, 2025, ISSN 2051-1426
Editor: BMJ
DOI: 10.1136/JITC-2025-013237

The Slovenian translational platform GlioBank for brain tumor research: Identification of molecular signatures of glioblastoma progression

Autores: Metka Novak, Bernarda Majc, Marta Malavolta, Andrej Porčnik, Jernej Mlakar, Matjaž Hren, Anamarija Habič, Mateja Mlinar, Ivana Jovčevska, Neja Šamec, Alja Zottel, Marija Skoblar Vidmar, Tina Vipotnik Vesnaver, Andrej Zupan, Alenka Matjašič, Saša Trkov Bobnar, Dejan Georgiev, Aleksander Sadikov, Roman Bošnjak, Borut Prestor, Radovan Komel, Tamara Lah Turnšek, Barbara Breznik
Publicado en: Neuro-Oncology Advances, Edición 7, 2025, ISSN 2632-2498
Editor: Oxford University Press (OUP)
DOI: 10.1093/NOAJNL/VDAF015

Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor–induced immune responses

Autores: Megan Cole, Panayiotis Anastasiou, Claudia Lee, Xiaofei Yu, Andrea de Castro, Jannes Roelink, Chris Moore, Edurne Mugarza, Martin Jones, Karishma Valand, Sareena Rana, Emma Colliver, Mihaela Angelova, Katey S. S. Enfield, Alastair Magness, Asher Mullokandov, Gavin Kelly, Tanja D. de Gruijl, Miriam Molina-Arcas, Charles Swanton, Julian Downward, Febe van Maldegem
Publicado en: Science Advances, Edición 10, 2024, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADL6464

Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models

Autores: Emanuela Senjor, Anamarija Habič, Urban Švajger, Ana Mitrović, Matic Proj, Andrej Porčnik, Borut Prestor, Miha Jerala, Matic Bošnjak, Stanislav Gobec, Barbara Breznik, Janko Kos, Milica Perišić Nanut
Publicado en: Frontiers in Immunology, Edición 16, 2025, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1708281

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Autores: Sendra Marta; Štampar Martina; Fras Katarina; Novoa Beatriz; Figueras Antonio; Žegura Bojana
Publicado en: Environment International, Edición Volume 171, January 2023, 107721, 2023, ISSN 0160-4120
Editor: New York : Elsevier, 1978
DOI: 10.1016/J.ENVINT.2022.107721

Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors

Autores: Rebecca R. J. Collins, Rebecca R. Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K. Lee, Samuel T. Peters, Jon P. Connelly, Shondra M. Pruett-Miller, Martine F. Roussel, Dinesh Rakheja, Heather S. Tillman, Patrick Ryan Potts, Klementina Fon Tacer
Publicado en: Acta Neuropathologica Communications, Edición 13, 2025, ISSN 2051-5960
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S40478-025-02055-3

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer

Autores: Enfield KSS, Colliver E, Lee CSY, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A, Consortium T, Jamal-Han
Publicado en: Cancer Discovery, Edición 2024 Jun 3; 14(6): 1018–1047, 2024, ISSN 2159-8290
Editor: American Association for Cancer Research
DOI: 10.1158/2159-8290.CD-23-1380

Combined Toxic Effects of BPA and Its Two Analogues BPAP and BPC in a 3D HepG2 Cell Model

Autores: Štampar Martina; Ravnjak Tim; Domijan Ana-Marija; Žegura Bojana
Publicado en: Molecules, Edición Vol 28, Iss 7, p 3085 (2023), 2023, ISSN 1420-3049
Editor: MDPI
DOI: 10.3390/MOLECULES28073085

Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

Autores: Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak
Publicado en: iScience, Edición 27, 2025, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/J.ISCI.2024.110604

Gene expression profiles associated with carboplatin chemoresistance in high-grade serous ovarian cancer: insights from 2D and 3D models

Autores: Vesna Kokondoska Grgič, Nika Marolt, Ajla Kubat, Tamara Dokmanović, Katja Kološa, Ivana Jovčevska, Tea Lanišnik Rižner
Publicado en: Biomedicine & Pharmacotherapy, Edición 195, 2026, ISSN 0753-3322
Editor: Elsevier BV
DOI: 10.1016/J.BIOPHA.2026.119010

Invasive properties of patient-derived glioblastoma cells after reversible electroporation <i>in vitro</i>

Autores: Anja Blazic, Bernarda Majc, Metka Novak, Barbara Breznik, Lea Rems
Publicado en: Radiology and Oncology, Edición 59, 2025, ISSN 1581-3207
Editor: Walter de Gruyter GmbH
DOI: 10.2478/RAON-2025-0058

Exploring the genotoxic potential of Bisphenol A and its emerging alternatives in an advanced in vitro 3D zebrafish hepatic cell model

Autores: Alja Štern, Katja Kološa, Špela Rozman, Bojana Žegura
Publicado en: Science of The Total Environment, Edición 1001, 2025, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2025.180527

Integrating computational fluid dynamics into organ-on-chip systems: a glioblastoma-centred design and validation framework

Autores: Hooman Taleban, Xinzhong Li, Zulfiqur Ali, Karunakaran Kalesh, Jai Prakash, Tugba Bagci-Onder, Barbara Breznik
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 13, 2026, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/FBIOE.2025.1716813

Anti-Vimentin Nanobody Decreases Glioblastoma Cell Invasion In Vitro and In Vivo

Autores: Alja Zottel; Metka Novak; Neja Šamec; Bernarda Majc; Sara Colja; Mojca Katrašnik; Miloš Vittori; Barbara Hrastar; Ana Rotter; Andrej Porčnik; Tamara Lah Turnšek; Radovan Komel; Barbara Breznik; Ivana Jovčevska
Publicado en: Cancers, Edición Volume 15, Edición 573 (2023), 2023, ISSN 2072-6694
Editor: MDPI
DOI: 10.3390/CANCERS15030573

Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from Cannabis sativa L

Autores: Alja Štern; Matjaž Novak; Katja Kološa; Jurij Trontelj; Sonja Žabkar; Tjaša Šentjurc; Metka Filipič; Bojana Žegura
Publicado en: Biomedicine &amp; Pharmacotherapy, 2024, ISSN 1950-6007
Editor: Elsevier
DOI: 10.1016/J.BIOPHA.2024.116969

Genotoxicity and heating Performance of VxFe3-xO4 nanoparticles in Health applications

Autores: Sanz-Sagué B, Sáenz-Hernández A, Moreno Maldonado AC, Fuentes-García JA, Nuñez JM, Zegura B, Stern A, Kolosa K, Rozman I, Torres TE, Goya GF
Publicado en: Chemico-Biological Interactions, Edición Volume 394, 1 May 2024, 110977, 2024, ISSN 0009-2797
Editor: Elsevier B.V.
DOI: 10.1016/J.CBI.2024.110977

Harnessing the power of an advanced <i>in vitro</i> 3D liver model and error-corrected duplex sequencing for the detection of mutational signatures

Autores: Gillian E Conway, Bérénice Chavanel, François Virard, Ume-Kulsoom Shah, Michael J Burgum, Stephen J Evans, Michael Korenjak, Laura E Thomas, Gareth J Jenkins, Jiri Zavadil, Shareen H Doak
Publicado en: Mutagenesis, 2025, ISSN 0267-8357
Editor: Oxford University Press (OUP)
DOI: 10.1093/MUTAGE/GEAF015