TWINNING FOR EXCELLENCE TO STRATEGICALLY ADVANCE RESEARCH IN CARCINOGENESIS AND CANCER

Informations projet

CutCancer

N° de convention de subvention: 101079113

DOI

10.3030/101079113

Projet clôturé

Date de signature de la CE 1 Août 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2025

Financé au titre de

• Widening participation and spreading excellence

Coût total

€ 1 197 550,00

Contribution de l’UE

€ 1 197 550,00

Coordonné par

NACIONALNI INSTITUT ZA BIOLOGIJO
Slovenia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (2)

Progress Report

The progress report as a deliverable at Month 17, will be the basis for the interim review meeting.

A protocol for the assessment of genomic instability in hepatic and lung 3D cell models

A detail protocol for the assessment of genomic instability in hepatic and lung 3D cell models will be prepared as a guideline for testing genotoxic activity of chemicals and nanoparticles. The protocol will contain all the necessary steps and information for the successful performance of the cytokinesis block micronucleus (CBMN) assay on hepatic and lung 3D cell models.

Publications

Peer reviewed articles (21)

GUT MICROBIOME IN CANCER: THE NEXT BIG OPPORTUNITY FOR BETTER PATIENT OUTCOMES?

Auteurs: Jure Povšin, Timotej Sotošek, Metka Novak, Barbara Breznik
Publié dans: Slovenian Veterinary Research, Numéro 62, 2025, ISSN 2385-8761
Éditeur: University of Ljubljana
DOI: 10.26873/SVR-2029-2024

Heterogenous mitochondrial ultrastructure and metabolism of human glioblastoma cells: differences between stem-like and differentiated cancer cells in response to chemotherapy

Auteurs: Urban Bogataj, Metka Novak, Simona Katrin Galun, Klementina Fon Tacer, Milos Vittori, Cornelis J.F. Van Noorden, Barbara Breznik
Publié dans: Radiology and Oncology, Numéro 59, 2025, ISSN 1581-3207
Éditeur: Walter de Gruyter GmbH
DOI: 10.2478/RAON-2025-0056

In vitro hepatic 3D cell models and their application in genetic toxicology: A systematic review

Auteurs: Martina Štampar, Bojana Žegura
Publié dans: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Numéro 900, 2025, ISSN 1383-5718
Éditeur: Elsevier BV
DOI: 10.1016/J.MRGENTOX.2024.503835

Safety of ferrite nanoparticles for biomedical applications: Cyto- and genotoxic effects of MxFe3-xO4 (M = Fe, Zn, Mn) in an Advanced 3D human hepatic in vitro model

Auteurs: Iza Rozman, Alvaro Gallo-Cordova, María del Puerto Morales, Marco A. Morales Ovalle, Gerardo F. Goya, Katja Kološa, Domen Hočevar, Bojana Žegura, Alja Štern
Publié dans: Biomedicine & Pharmacotherapy, Numéro 195, 2026, ISSN 0753-3322
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOPHA.2025.118950

Immune-modulating effects on tumor-draining lymph nodes of neoadjuvant chemoradiotherapy combined with dual immunotherapy in patients with T3-4N0-2 NSCLC

Auteurs: Ezgi B Ulas, Sofie J I Koomen, Anne Vrijmoet, Ilias Houda, H Ibrahim Korkmaz, Chris Dickhoff, Idris Bahce, Suresh Senan, Tanja D de Gruijl, Marieke F Fransen, Teodora Radonic, Febe van Maldegem, Famke L Schneiders
Publié dans: Journal for ImmunoTherapy of Cancer, Numéro 13, 2025, ISSN 2051-1426
Éditeur: BMJ
DOI: 10.1136/JITC-2025-013237

The Slovenian translational platform GlioBank for brain tumor research: Identification of molecular signatures of glioblastoma progression

Auteurs: Metka Novak, Bernarda Majc, Marta Malavolta, Andrej Porčnik, Jernej Mlakar, Matjaž Hren, Anamarija Habič, Mateja Mlinar, Ivana Jovčevska, Neja Šamec, Alja Zottel, Marija Skoblar Vidmar, Tina Vipotnik Vesnaver, Andrej Zupan, Alenka Matjašič, Saša Trkov Bobnar, Dejan Georgiev, Aleksander Sadikov, Roman Bošnjak, Borut Prestor, Radovan Komel, Tamara Lah Turnšek, Barbara Breznik
Publié dans: Neuro-Oncology Advances, Numéro 7, 2025, ISSN 2632-2498
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/NOAJNL/VDAF015

Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor–induced immune responses

Auteurs: Megan Cole, Panayiotis Anastasiou, Claudia Lee, Xiaofei Yu, Andrea de Castro, Jannes Roelink, Chris Moore, Edurne Mugarza, Martin Jones, Karishma Valand, Sareena Rana, Emma Colliver, Mihaela Angelova, Katey S. S. Enfield, Alastair Magness, Asher Mullokandov, Gavin Kelly, Tanja D. de Gruijl, Miriam Molina-Arcas, Charles Swanton, Julian Downward, Febe van Maldegem
Publié dans: Science Advances, Numéro 10, 2024, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADL6464

Targeting cystatin F activation enhances NK cell cytotoxicity in glioblastoma models

Auteurs: Emanuela Senjor, Anamarija Habič, Urban Švajger, Ana Mitrović, Matic Proj, Andrej Porčnik, Borut Prestor, Miha Jerala, Matic Bošnjak, Stanislav Gobec, Barbara Breznik, Janko Kos, Milica Perišić Nanut
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1708281

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Auteurs: Sendra Marta; Štampar Martina; Fras Katarina; Novoa Beatriz; Figueras Antonio; Žegura Bojana
Publié dans: Environment International, Numéro Volume 171, January 2023, 107721, 2023, ISSN 0160-4120
Éditeur: New York : Elsevier, 1978
DOI: 10.1016/J.ENVINT.2022.107721

Melanoma antigens in pediatric medulloblastoma contribute to tumor heterogeneity and species-specificity of group 3 tumors

Auteurs: Rebecca R. J. Collins, Rebecca R. Florke Gee, Sima Tozandehjani, Tara Bayat, Maria Camila Hoyos Sanchez, Juan Sebastian Solano Gutierrez, Barbara Breznik, Anna K. Lee, Samuel T. Peters, Jon P. Connelly, Shondra M. Pruett-Miller, Martine F. Roussel, Dinesh Rakheja, Heather S. Tillman, Patrick Ryan Potts, Klementina Fon Tacer
Publié dans: Acta Neuropathologica Communications, Numéro 13, 2025, ISSN 2051-5960
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S40478-025-02055-3

Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer

Auteurs: Enfield KSS, Colliver E, Lee CSY, Magness A, Moore DA, Sivakumar M, Grigoriadis K, Pich O, Karasaki T, Hobson PS, Levi D, Veeriah S, Puttick C, Nye EL, Green M, Dijkstra KK, Shimato M, Akarca AU, Marafioti T, Salgado R, Hackshaw A, Consortium T, Jamal-Han
Publié dans: Cancer Discovery, Numéro 2024 Jun 3; 14(6): 1018–1047, 2024, ISSN 2159-8290
Éditeur: American Association for Cancer Research
DOI: 10.1158/2159-8290.CD-23-1380

Combined Toxic Effects of BPA and Its Two Analogues BPAP and BPC in a 3D HepG2 Cell Model

Auteurs: Štampar Martina; Ravnjak Tim; Domijan Ana-Marija; Žegura Bojana
Publié dans: Molecules, Numéro Vol 28, Iss 7, p 3085 (2023), 2023, ISSN 1420-3049
Éditeur: MDPI
DOI: 10.3390/MOLECULES28073085

Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma

Auteurs: Bernarda Majc, Anamarija Habič, Marta Malavolta, Miloš Vittori, Andrej Porčnik, Roman Bošnjak, Jernej Mlakar, Alenka Matjašič, Andrej Zupan, Marija Skoblar Vidmar, Tamara Lah Turnšek, Aleksander Sadikov, Barbara Breznik, Metka Novak
Publié dans: iScience, Numéro 27, 2025, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/J.ISCI.2024.110604

Gene expression profiles associated with carboplatin chemoresistance in high-grade serous ovarian cancer: insights from 2D and 3D models

Auteurs: Vesna Kokondoska Grgič, Nika Marolt, Ajla Kubat, Tamara Dokmanović, Katja Kološa, Ivana Jovčevska, Tea Lanišnik Rižner
Publié dans: Biomedicine & Pharmacotherapy, Numéro 195, 2026, ISSN 0753-3322
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOPHA.2026.119010

Invasive properties of patient-derived glioblastoma cells after reversible electroporation <i>in vitro</i>

Auteurs: Anja Blazic, Bernarda Majc, Metka Novak, Barbara Breznik, Lea Rems
Publié dans: Radiology and Oncology, Numéro 59, 2025, ISSN 1581-3207
Éditeur: Walter de Gruyter GmbH
DOI: 10.2478/RAON-2025-0058

Exploring the genotoxic potential of Bisphenol A and its emerging alternatives in an advanced in vitro 3D zebrafish hepatic cell model

Auteurs: Alja Štern, Katja Kološa, Špela Rozman, Bojana Žegura
Publié dans: Science of The Total Environment, Numéro 1001, 2025, ISSN 0048-9697
Éditeur: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2025.180527

Integrating computational fluid dynamics into organ-on-chip systems: a glioblastoma-centred design and validation framework

Auteurs: Hooman Taleban, Xinzhong Li, Zulfiqur Ali, Karunakaran Kalesh, Jai Prakash, Tugba Bagci-Onder, Barbara Breznik
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 13, 2026, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/FBIOE.2025.1716813

Anti-Vimentin Nanobody Decreases Glioblastoma Cell Invasion In Vitro and In Vivo

Auteurs: Alja Zottel; Metka Novak; Neja Šamec; Bernarda Majc; Sara Colja; Mojca Katrašnik; Miloš Vittori; Barbara Hrastar; Ana Rotter; Andrej Porčnik; Tamara Lah Turnšek; Radovan Komel; Barbara Breznik; Ivana Jovčevska
Publié dans: Cancers, Numéro Volume 15, Numéro 573 (2023), 2023, ISSN 2072-6694
Éditeur: MDPI
DOI: 10.3390/CANCERS15030573

Exploring the safety of cannabidiol (CBD): A comprehensive in vitro evaluation of the genotoxic and mutagenic potential of a CBD isolate and extract from Cannabis sativa L

Auteurs: Alja Štern; Matjaž Novak; Katja Kološa; Jurij Trontelj; Sonja Žabkar; Tjaša Šentjurc; Metka Filipič; Bojana Žegura
Publié dans: Biomedicine &amp; Pharmacotherapy, 2024, ISSN 1950-6007
Éditeur: Elsevier
DOI: 10.1016/J.BIOPHA.2024.116969

Genotoxicity and heating Performance of VxFe3-xO4 nanoparticles in Health applications

Auteurs: Sanz-Sagué B, Sáenz-Hernández A, Moreno Maldonado AC, Fuentes-García JA, Nuñez JM, Zegura B, Stern A, Kolosa K, Rozman I, Torres TE, Goya GF
Publié dans: Chemico-Biological Interactions, Numéro Volume 394, 1 May 2024, 110977, 2024, ISSN 0009-2797
Éditeur: Elsevier B.V.
DOI: 10.1016/J.CBI.2024.110977

Harnessing the power of an advanced <i>in vitro</i> 3D liver model and error-corrected duplex sequencing for the detection of mutational signatures

Auteurs: Gillian E Conway, Bérénice Chavanel, François Virard, Ume-Kulsoom Shah, Michael J Burgum, Stephen J Evans, Michael Korenjak, Laura E Thomas, Gareth J Jenkins, Jiri Zavadil, Shareen H Doak
Publié dans: Mutagenesis, 2025, ISSN 0267-8357
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/MUTAGE/GEAF015