Project description
Twinning supports Portugal’s innovation in protein-folding pathologies and treatments
Proteins are the workhorses of cells. These macromolecules have complicated 3D structures that directly influence the proteins’ functioning. The folding and misfolding of proteins is linked to a plethora of so-called conformational diseases including cataracts, metabolic disorders and neurodegenerative pathologies. Understanding the mechanisms of healthy and pathological self-assembly is key to modulating protein interactions that will underlie the rational design of protein-based biomaterials and therapeutic antibodies to treat these pathologies. The EU-funded TWIN2PIPSA project will enhance Portugal’s experimental and computational capabilities for research and innovation in the field through twinning with three universities that are global leaders.
Objective
TWIN2PIPSA will improve R&I capacities of FC.ID/ULisboa (Portugal) in the field of protein folding biophysics and conformational diseases by partnering in joint Twinning activities with three world-leading research and technological development performers: the University of Cambridge (UCAM), the University of Copenhagen (UCPH), and Tel Aviv University (TAU). The folding and misfolding of proteins, their interactions and self-assembly in cells is central to biology and has implications in diseases that affect millions of people worldwide. The so-called conformational diseases include cataracts, metabolic disorders and neurodegenerative pathologies such as Alzheimer’s Disease. Knowledge on the ability to modulate protein interactions and self-assembly is critical to develop applications of protein-based biomaterials like bioadhesive glues or to design therapeutic antibody biologics. TWIN2PIPSA fulfils local needs and will generate outstanding contributions through investigations of pathological self-assembly in vitro and in living cells, nanoscale characterization of protein-based materials and implementation of integrative biomolecular simulations that will raise the international profile and scientific standing of FC.ID/ULisboa. This will enable a local cluster of excellence whose scientific and technological breakthroughs will empower both project partners and the industry sector in their regional innovation ecosystems. The partnership and network will significantly reinforce the R&I capabilities of the widening institution and Portugal’s innovation performance. TWIN2PIPSA comprises several Twinning activities: staff exchanges, secondments to partners, expert visits, meetings, training schools and a joint exploratory project that will translate into biomedical and biotechnological outcomes. Dedicated activities to reinforce research management capacities and administrative skills of FC.ID/ULisboa grant office through mentoring and staff exchanges are also planned.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences ecology ecosystems
- natural sciences biological sciences biophysics
- engineering and technology industrial biotechnology biomaterials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.4.1 - Widening participation and spreading excellence
MAIN PROGRAMME
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HORIZON.4.1.2 - Twinning
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-CSA - HORIZON Coordination and Support Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-WIDERA-2021-ACCESS-03
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1749 016 Lisbon
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.