Twinning for excellence in biophysics of protein interactions and self-assembly

Project Information

TWIN2PIPSA

Grant agreement ID: 101079147

DOI 10.3030/101079147

EC signature date 4 July 2022

Start date 1 October 2022

End date 30 September 2025

Funded under

• Widening participation and spreading excellence

Total cost € 1 228 957,00

EU contribution € 1 228 957,00

Coordinated by

FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS
Portugal

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data management plan

Websites, patent fillings, videos etc. (1)

Project website and digital platform structure

Publications

Other (3)

Identifying functional sites at scale

Author(s): Cagiada, Matteo
Published in: 2023
DOI: 10.5281/zenodo.10409579

Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer

Author(s): Ana Rita Brás; Ana Lopes; Nuno Mendes; Paulo J. Costa; Anabela Ferreira; Sara Granja; Ana Paula Silva; Francisco Tortosa; Fátima Baltazar; Fátima Gärtner; Maria João Sousa; Andreia Valente; Ana Preto
Published in: bioRxiv, 2023
Publisher: bioRxiv
DOI: 10.1101/2023.08.09.552513

Understanding intrinsically disordered proteins: from integrative modelling to design

Author(s): Pesce, Francesco
Published in: 2023
DOI: 10.5281/zenodo.10379566

Peer reviewed articles (13)

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

Author(s): Pedro M. P. Fernandes; Romina A. Guedes; Bruno L. Victor; Jorge A. R. Salvador; Rita C. Guedes
Published in: Frontiers in Chemistry, Issue 11-2023, 2024, ISSN 2296-2646
Publisher: Frontiers Media
DOI: 10.3389/fchem.2023.1322628

Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease

Author(s): Vasco Neto; Bruno Lourenço Victor; Nuno Galamba
Published in: Journal of Medicinal Chemistry, 2023, ISSN 0022-2623
Publisher: American Chemical Society
DOI: 10.26434/chemrxiv-2023-qrzl0

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Author(s): António J. Figueira; Joana Saavedra; Isabel Cardoso; Cláudio M. Gomes
Published in: Frontiers in Neuroscience, 2023, ISSN 1662-453X
Publisher: Frontiers
DOI: 10.3389/fnins.2023.1162741

Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology

Author(s): Romina Coelho; Chiara A. De Benedictis; Ann Katrin Sauer; António J. Figueira; Hélio Faustino; Andreas M. Grabrucker; Cláudio M. Gomes
Published in: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031787

Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches

Author(s): Inês Paccetti-Alves; Marta S. P. Batista; Catarina Pimpão; Bruno L. Victor; Graça Soveral
Published in: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 6004, 2023, ISSN 1422-0067
Publisher: MDPI
DOI: 10.3390/ijms24066004

Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12

Author(s): Tiina J. Ahonen; Choa P. N; Beatriz Farinha; Bárbara Almeida; Bruno L. Victor; Christopher Reynolds; Eija Kalso; Jari Yli-Kauhaluoma; Jennifer Greaves; Vânia M. Moreira
Published in: ACS Medicinal Chemistry Letters, 2023, ISSN 1948-5875
Publisher: American Chemical Society
DOI: 10.1021/acsmedchemlett.3c00313

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor

Author(s): Mickael Diallo; Constança Pimenta; Fernanda Murtinheira; Daniela Martins-Alves; Francisco R. Pinto; André Abrantes da Costa; Ricardo Letra-Vilela; Vanesa Martin; Carmen Rodriguez; Mário S. Rodrigues; Federico Herrera
Published in: Cellular Oncology, 2023, ISSN 2211-3436
Publisher: Springer Nature
DOI: 10.21203/rs.3.rs-3188959/v1

Assessment of Halogen Off-Center Point-Charge Models Using Explicit Solvent Simulations

Author(s): Andreia Fortuna; Paulo J. Costa
Published in: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Publisher: ACS Publications
DOI: 10.26434/chemrxiv-2023-sgbfb

Is spastic ataxia 8 a protein misfolding disorder?

Author(s): Pedro Ferreira-Peralta; Brenda França; Fernanda Murtinheira; Mario S. Rodrigues; Federico Herrera
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, ISSN 0925-4439
Publisher: Elsevier B.V.
DOI: 10.1016/j.bbadis.2023.166882

Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail

Author(s): André M.M. Gomes; Paulo J. Costa; Miguel Machuqueiro
Published in: BBA Advances, 2023, ISSN 2667-1603
Publisher: Elsevier B.V.
DOI: 10.1016/j.bbadva.2023.100099

Influence of Iodine Merz–Singh–Kollman Radius on the Calculated Charges and Hydration Free Energies of Iodinated Molecules

Author(s): Andreia Fortuna; Pedro M. S. Suzano; Miguel Machuqueiro; Paulo J. Costa
Published in: Journal of Computational Biophysics and Chemistry, Issue 04, 2024, ISSN 2737-4165
Publisher: World Scientific Publishing
DOI: 10.1142/S2737416523500722

Journal of Biological Chemistry

Author(s): Justine Mortelecque; Orgeta Zejneli; Séverine Bégard; Margarida C. Simões; Lea ElHajjar; Marine Nguyen; François-Xavier Cantrelle; Xavier Hanoulle; Jean-Christophe Rain; Morvane Colin; Cláudio M. Gomes; Luc Buée; Isabelle Landrieu; ClémenDanis C, Dupré E.
Published in: Journal of Biological Chemistry, Issue 4, 2024, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.107163

Intrinsic Bond Strength Index as a halogen bond interaction energy predictor

Author(s): Ona Šivickytė; Paulo J. Costa
Published in: Physical Chemistry Chemical Physics, 2023, ISSN 1463-9084
Publisher: Royal Society of Chemistry
DOI: 10.26434/chemrxiv-2022-c6npj

Thesis and dissertations (3)

Investigation of S100 proteins and their role in huntingtin aggregation

Author(s): Marta Sofia Silva da Cruz Botelho
Published in: ULisboa Repository, 2023
Publisher: Author Edition

The role of post-translational modifications on NKX6-2 behavior and function

Author(s): Brenda Gabriella França
Published in: NOVA University Repository, 2023
Publisher: Author Edition

Sea urchin inspired adhesive proteins - expression and purification of Nectin structural domains

Author(s): Mariana Rodrigues dos Santos
Published in: ULisboa Repository, 2023
Publisher: Author Edition