TWINNING FOR A EUROPEAN CONSORTIUM OF RECTAL CANCER RESEARCH INSTITUTIONS THROUGH STEPPING UP SCIENTIFIC, TECHNOLOGICAL AND INNOVATION EXCELLENCE OF IORS

Project Information

STEPUPIORS

Grant agreement ID: 101079217

DOI

10.3030/101079217

Project closed

EC signature date 14 July 2022

Start date 1 October 2022

End date 30 September 2025

Funded under

• Widening participation and spreading excellence

Total cost

€ 1 500 000,00

EU contribution

€ 1 500 000,00

Coordinated by

INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE
Serbia

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Outreach activities

Transmitting results of the project to the general publicDesign IORS social networks Portal (IDIBAPS/HCB - in collaboration with IORS, BRFAA, NKI)Prepare outreach activities for the general public (IORS - with expert advice from BRFAA, IDIBAPS/HCB and NKI)

Documents, reports (5)

Midterm report of staff exchanges, expert visits to IORS and research proposals submitted

Research and administrative staff exchanges (IORS and BRFAA - in collaboration with IDIBAPS and NKI) Expert visits to IORS (BRFAA, IDIBAPS and NKI, one visit each)Remote virtual training on omics data analysis (BRFAA, IDIBAPS and NKI - expertise applied to IORS staff)Preparation and submission of research proposals with emphasis on MSCA doctoral networks and postdoctoral fellowships (BRFAA, IDIBAPS and NKI AVL - expertise applied to IORS staff)

Increased IORS human capacities for biobank management and oversight

1.4 Train IORS personnel for biobank management and oversight (IDIBAPS/HCB and NKI)

Teaching Materials and evaluation report for workshops and summer school

3.4 Workshops on omics approaches, skills for careers in academia/industry, and proposal writing (BRFAA, IDIBAPS and NKI expertise applied to IORS staff)3.5 Summer school on clinical applications of liquid biopsies (NKI - expertise applied to IORS staff)

Final report of staff exchanges, expert visits to IORS and research proposals submitted

Research and administrative staff exchanges (IORS and BRFAA - in collaboration with IDIBAPS and NKI) Expert visits to IORS (BRFAA, IDIBAPS and NKI, one visit each)Remote virtual training on omics data analysis (BRFAA, IDIBAPS and NKI - expertise applied to IORS staff)Preparation and submission of research proposals with emphasis on MSCA doctoral networks and postdoctoral fellowships (BRFAA, IDIBAPS and NKI AVL - expertise applied to IORS staff)

Open-access research publications and presentations in scientific meetings

4.3 Writing and publishing open-access research articles (IORS - in collaboration with BRFAA, IDIBAPS/HCB and NKI)4.4 Preparing presentations for scientific meetings of the field (IORS - in collaboration with BRFAA, IDIBAPS/HCB and NKI)

Demonstrators, pilots, prototypes (1)

Establishment of a Research Management office at IORS

Form a Research Management Office at IORS by training IORS staff in specific management procedures and protocols (IORS - with expert advice from BRFAA, IDIBAPS/HCB and NKI)Train IORS staff on pre- and post-grant project management activities

Other (1)

Increasing professional capacities for omics analyses

2.4.Train IORS personnel for omics analyses (BRFAA, IDIBAPS/HCB and NKI expertise applied to IORS staff)

Publications

Thesis and dissertations (2)

Ispitivanje prognostičkih i prediktivnih kliničkih i molekularnih markera u lečenju lokalno uznapredovalog karcinoma rektuma neoadjuvantnom radiohemioterapijom primenom volumnog rotacionog planiranja zračne terapije i simultanog integrisanog boost-a

Author(s): Marinkovic Mladen
Published in: 2024
Publisher: Faculty of Medicine, University of Belgrade

Health economic evaluation of liquid biopsy in treatment decision management of patients with locally advanced rectal cancer in Serbia

Author(s): Milena Cavic
Published in: 2025
Publisher: Faculty of Medicine, University of Belgrade, Serbia
DOI: 10.5281/ZENODO.17769433

Peer reviewed articles (8)

Abstracts

Published in: Molecular Oncology, Issue 19, 2025, ISSN 1574-7891
Publisher: Wiley
DOI: 10.1002/1878-0261.70070

Methylenetetrahydrofolate reductase polymorphic variants C677T and A1298C in rectal cancer in Slavic population: significance for cancer risk and response to chemoradiotherapy

Author(s): Stanojevic A, Spasic J, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Djuric A, Zoidakis J, Fijneman R.J.A, Castellvi-Bel S, Cavic M.
Published in: Frontier in Genetics, Issue 14, 2024, ISSN 1664-8021
Publisher: Frontiers
DOI: 10.1101/2023.09.21.23295916

Exploring novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Author(s): Marinkovic M, Stojanovic-Rundic S, Stanojevic A, Ostojic M, Gavrilovic D, Jankovic R, Maksimovic N, Stroggilos R, Zoidakis J, Castellví-Bel S, Fijneman RJA, Cavic M.
Published in: Frontier in Genetics, Issue 14, 2023, ISSN 1664-8021
Publisher: Frontiers Media S.A.
DOI: 10.1101/2023.06.20.23291673

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer

Author(s): Vuletic A, Mirjacic Martinovic K, Spasic J.
Published in: Pharmaceutics, Issue 16(1):54, 2023, ISSN 1999-4923
Publisher: MDPI (Basel, Switzerland)
DOI: 10.20944/preprints202311.1805.v1

Performance and Dimensionality of Pretreatment MRI Radiomics in Rectal Carcinoma Chemoradiotherapy Prediction

Author(s): Marinković, M.; Stojanović-Rundić, S.; Stanojevic, A.; Tomašević, A.; Janković, R.; Zoidakis, J.; Castellví-Bel, S.; Fijneman, R.J.; Čavić, M.; Radulović, M
Published in: Journal of Clinical Medicine, Issue 13(2):421, 2024, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/preprints202310.0560.v1

Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy

Author(s): Stanojevic A, Samiotaki M, Lygirou V, Marinkovic M, Nikolic V, Stojanovic-Rundic S, Jankovic R, Vlahou A, Panayotou G, Fijneman RJA, Castellví-Bel S, Zoidakis J, Cavic M
Published in: Int J Mol Sci, Issue 24(20), 2023, ISSN 1661-6596
Publisher: MDPI (Basel, Switzerland)
DOI: 10.1101/2023.05.12.23289671

Precision public health perspective: Is genomic population screening a viable option for the early detection of risks for oncological diseases? Reflections from Serbia

Author(s): Bosiljka Đikanović, Janko Janković, Milena Čavić
Published in: Srpski medicinski casopis Lekarske komore, Issue 6, 2025, ISSN 2737-971X
Publisher: Centre for Evaluation in Education and Science (CEON/CEES)
DOI: 10.5937/smclk6-57145

Dose Escalation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Short-Term Efficacy and Toxicity of VMAT–SIB vs. 3D-CRT

Author(s): Suzana Stojanovic-Rundic, Mladen Marinkovic, Aleksandra Stanojevic, Dusica Gavrilovic, Radmila Jankovic, Natasa Maksimovic, Aleksandar Tomasevic, Predrag Petrasinovic, Sandra Radenkovic, Milena Cavic
Published in: Medicina, Issue 61, 2025, ISSN 1648-9144
Publisher: MDPI AG
DOI: 10.3390/MEDICINA61030483

Conference proceedings (19)

Is there a relation between hematological toxicity and response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer?

Author(s): Marinkovic M, Stojanović-Rundic S, Djurić A, Stanojevic A, Gavrilovic D, Jankovic R, Zoidakis J, Castellvi-Bel S, Fijneman R, Cavic M.
Published in: 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference : present and future of toxicology: challenges and opportunities: abstract book, Issue 1, 2023, ISBN 978-86-917867-3-1
Publisher: Belgrade : [s.n.], 2023
DOI: 10.5281/ZENODO.17780517

Navigating ELSI for FAIR multiomics data management within STEPUPIORS international rectal cancer project

Author(s): Tanić M, Bierkens M, Radulović M, Stanojević A, Marinković M, Krivokuća A, Janković R, Đurić A, Castellvi-Bel S, Zoidakis S, Fijneman R, Čavić M
Published in: Abstract book of the 5th Belgrade Bioinformatics Conference – BelBi2024, Issue 1, 2024
Publisher: Belgrade Bioinformatics Conference, University of Belgrade
DOI: 10.5281/ZENODO.17799315

Employing widening EU funds to train the next generation of liquid biopsy researchers – example of the STEPUPIORS collaborative rectal cancer project

Author(s): Cavic M, Djuric A, Marinkovic M, Stanojevic A, Tanic M, Damjanovic A, Spasic J, Bjelogrlic S, Djordjic Crnogorac M, Vuletic A, Mirjacic Martinovic K, Radulovic M, Stojanovic-Rundic S, Krivokuca A, Vuk
Published in: Abstract book of the EACR-AstraZeneca Conference: Circulating Nucleic Acids (cfDNA/ctDNA): In use, in view and on the horizon congress, Issue 1, 2025
Publisher: European Association for Cancer Research
DOI: 10.5281/ZENODO.17818070

Prognostic factors for disease-free interval in patients with rectal cancer treated with neoadjuvant chemoradiotherapy and dose intensification

Author(s): Marinković M, Stojanović-Rundić S, Stanojević A, Tomašević A, Janković R, Djurić A, Zoidakis J, Castellví-Bel S, Fijneman RJA, Čavić M.
Published in: Radiotherapy and Oncology, Issue 206 (Suppl. 1): 1223-1224., 2025, ISSN 0167-8140
Publisher: European Society for Radiotherapy & Oncology
DOI: 10.5281/ZENODO.17818349

The Road from Human Sample Collections to the First Rectal Cancer Biobank at the Institute for Oncology and Radiology of Serbia

Author(s): A. Djuric, M. Tanic, S. Bjelogrlic, S. StojanovicRundic, M. Marinkovic, A. Stanojevic, R. Fijenman, S. Castellví-Bel, J. Zoidakis, M. Cavic
Published in: Molecular Oncology, Issue 17 (Suppl. 1) (2023) 1–597. p464-465, 2023, ISSN 1574-7891
Publisher: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13469

Employing widening funds to address inequity in cancer research - example of the STEPUPIORS collaborative rectal cancer project

Author(s): Cavic M, Djuric A, Marinkovic M, Stanojevic A, Tanic M, Bjelogrlic S, Spasic J, Damjanovic A, Djordjic Crnogorac M, Vuletic A, Mirjacic Martinovic K, Radulovic M, Stojanovic-Rundic S, Krivokuca A, Ja
Published in: Cancer Research, Issue 84 (6_Supplement): 1304, 2024, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.5281/ZENODO.17775214

Predicting response to chemoradiotherapy in locally advanced rectal cancer using MRI-based radiomics features

Author(s): Marinković M, Stojanović-Rundić S, Stanojević A, Janković R, Zoidakis J, Castellvi-Bel S, J.A. Fijneman R, Čavić M, Radulovic M.
Published in: Oncology Insights, Issue 3009-3848, 2023
Publisher: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795607

Expanding the Landscape of Professional Project Management to Support Cancer Research in Serbia.

Author(s): Djuric A, Radulovic M, Damjanovic A, Fijneman R, Castellvi-Bel S, Zoidakis J, Cavic M.
Published in: Molecular Oncology, Issue Vol. 18. Supp. 1, 2024, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.5281/ZENODO.17780114

Novel 1-benzhydryl piperazine scaffold-based HDAC inhibitor b7 induces synergistic antiproliferative effect with vemurafenib in colorectal cancer cells harboring BRAF mutation.

Author(s): Vuletic A, Mirjačić Martinović K, Srdić-Rajić T, Tišma Miletić N, Đurić A, Nikolić K, Ružić D, Čavić M.
Published in: Molecular Oncology, Issue 19 (S1): 160-161, 2025, ISSN 1574-7891
Publisher: Elsevier BV
DOI: 10.5281/ZENODO.17775413

Correlation between genetic and proteomic expression of predictive biomarkers of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer identified by DIA mass spectrometry

Author(s): A. Stefanovic, V. Lygirou, S. Stojanović-Rundić, R. Janković, S. Castellvi-Bel, R. J.A. Fijneman, A. Vlahou, J. Zoidakis, M. Samiotaki, M. Čavić
Published in: Molecular Oncology, Issue 17 (Suppl. 1) (2023) 1–597. p96-97, 2023, ISSN 1574-7891
Publisher: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13469

International Collaborative Biobanking: Shaping the future together

Author(s): Botta-Orfila T, Bjelogrlic S, Tanic M, Krivokuca A, Soler-Ventura A, Djuric A, Rodríguez-Vilarrupla A, Zoidakis J, Fijneman R, Castellví-Bel S, Cavic M.
Published in: Abstract book of the Europe Biobank Week Congress 2024, Issue 1, 2024
Publisher: Europe Biobank Week Congress
DOI: 10.5281/ZENODO.17795879

Importance of Biobanks for Translational Cancer Research in Serbia.

Author(s): Djuric A, Tanic M, Bjelogrlic S, Marinkovic M, Stanojevic A, Spasic J, Stojanovic-Rundic S, Jankovic R, Krivokuca A, Mirjacic Martinovic K, Vuletic A, Djordjic Crnogorac M, Damjanovic A, Radulovic M,
Published in: Proceedings of the 73rd Panhellenic Conference of the Hellenic Society of Biochemistry and Molecular Biology, Issue 1, 2023
Publisher: Panhellenic Conference of the Hellenic Society of Biochemistry and Molecular Biology
DOI: 10.5281/ZENODO.17795787

Meta-analysis of publicly available transcriptomics data reveals predictive biomarkers for neoadjuvant chemoradiotherapy in rectal cancer

Author(s): Stanojevic A, Stroggilos R, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Castellvi-Bel S, Fijneman R, Vlahou A, Zoidakis J, Cavic M.
Published in: Radiotherapy and Oncology, Issue Volume 206 (Suppl. 1): 4032-4033, 2025, ISSN 0167-8140
Publisher: European Society for Radiotherapy & Oncology
DOI: 10.5281/ZENODO.17826580

Detection of viral proteins in locally advanced rectal cancer patient samples by mass spectrometry – predictive potential for response to neoadjuvant chemoradiotherapy.

Author(s): Stanojević A, Samiotaki M, Lygirou V, Marinković M, Nikolić V, Stojanović-Rundić S, Janković R, Banko A, Miljanović D, Vlahou A, Panayotou G, J.A. Fijneman R, Castellvi-Bel S, Zoidakis J, Čavi
Published in: Oncology Insights, Issue 1, 2023, ISSN 3009-3848
Publisher: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795659

The role of CEA and CA 19-9 tumor markers in predicting response to neoadjuvant radiochemotherapy in locally advanced rectal cancer

Author(s): Marinković M, Stojanović-Rundić S, Stanojević A, Janković R, Zoidakis J, Castellvi-Bel S, Fijneman R, Čavić M.
Published in: Abstract book of the Third Serbian Radiation Oncology Congress, 2024
Publisher: Oncology Institute of Vojvodina
DOI: 10.5281/ZENODO.17826664

Biobanking from Scratch: A Roadmap to Setup a Rectal Cancer Biobank Within the STEPUPIORS Project

Author(s): Tanic M, Bjelogrlic S, Krivokuca A, Djuric A, Cavic M.
Published in: Abstract book of HDIR-7: Advances in Cancer Research & Treatment, Issue 1, 2024
Publisher: Croatioan Association for Cancer Research
DOI: 10.5281/ZENODO.17817884

Initial absolute basophil, eosinophil and monocyte counts as potential predictive markers in locally advanced rectal cance

Author(s): Marinković M, Stojanović-Rundić S, Stefanović A, Janković R, Zoidakis J., Castellvi-Bel S., Fijneman R., Cavic M
Published in: Abstract book of the 72th Annual Conference of the Hellenic Society of Biochemistry & Molecular Biology, Issue 11, 2022
Publisher: 72 Hellenic Society of Biochemistry & Molecular Biology
DOI: 10.5281/ZENODO.17792526

Establishment of a first cancer Biobank at the Institute for Oncology and Radiology of Serbia –advantages, challenges and future perspective

Author(s): Bjelogrlić S, Tanić M, Marinković M, Jelena Spasić S, Đurić S, Stojanović-Rundić S, Stanojević A, Đorđić Crnogorac M, Mirjačić Martinović K, Vuletić A, Damjanović Veličković A, Radu
Published in: Oncology Insights, Issue 1, 2023, ISSN 3009-3848
Publisher: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795720

In-depth proteomic characterization of the response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer using data-independent acquisition mass spectrometry (DIA-MS)

Author(s): Stefanović A, Lygirou V, Marinković M, Stojanović-Rundić S, Janković R, Vlahou A, Zoidakis J, Fijneman R., Castellvi-Bel S., Samiotaki M, Čavić M
Published in: 72th Annual Conference of the Hellenic Society of Biochemistry & Molecular Biology Abstract book, Issue 11, 2022
Publisher: Hellenic Society of Biochemistry & Molecular Biology
DOI: 10.5281/ZENODO.17792610