TWINNING FOR A EUROPEAN CONSORTIUM OF RECTAL CANCER RESEARCH INSTITUTIONS THROUGH STEPPING UP SCIENTIFIC, TECHNOLOGICAL AND INNOVATION EXCELLENCE OF IORS

Informacje na temat projektu

STEPUPIORS

Identyfikator umowy o grant: 101079217

DOI

10.3030/101079217

Projekt został zamknięty

Data podpisania przez KE 14 Lipca 2022

Data rozpoczęcia 1 Października 2022

Data zakończenia 30 Września 2025

Finansowanie w ramach

• Widening participation and spreading excellence

Koszt całkowity

€ 1 500 000,00

Wkład UE

€ 1 500 000,00

Koordynowany przez

INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE
Serbia

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Websites, patent fillings, videos etc. (1)

Outreach activities

Transmitting results of the project to the general publicDesign IORS social networks Portal (IDIBAPS/HCB - in collaboration with IORS, BRFAA, NKI)Prepare outreach activities for the general public (IORS - with expert advice from BRFAA, IDIBAPS/HCB and NKI)

Documents, reports (5)

Midterm report of staff exchanges, expert visits to IORS and research proposals submitted

Research and administrative staff exchanges (IORS and BRFAA - in collaboration with IDIBAPS and NKI) Expert visits to IORS (BRFAA, IDIBAPS and NKI, one visit each)Remote virtual training on omics data analysis (BRFAA, IDIBAPS and NKI - expertise applied to IORS staff)Preparation and submission of research proposals with emphasis on MSCA doctoral networks and postdoctoral fellowships (BRFAA, IDIBAPS and NKI AVL - expertise applied to IORS staff)

Increased IORS human capacities for biobank management and oversight

1.4 Train IORS personnel for biobank management and oversight (IDIBAPS/HCB and NKI)

Teaching Materials and evaluation report for workshops and summer school

3.4 Workshops on omics approaches, skills for careers in academia/industry, and proposal writing (BRFAA, IDIBAPS and NKI expertise applied to IORS staff)3.5 Summer school on clinical applications of liquid biopsies (NKI - expertise applied to IORS staff)

Final report of staff exchanges, expert visits to IORS and research proposals submitted

Research and administrative staff exchanges (IORS and BRFAA - in collaboration with IDIBAPS and NKI) Expert visits to IORS (BRFAA, IDIBAPS and NKI, one visit each)Remote virtual training on omics data analysis (BRFAA, IDIBAPS and NKI - expertise applied to IORS staff)Preparation and submission of research proposals with emphasis on MSCA doctoral networks and postdoctoral fellowships (BRFAA, IDIBAPS and NKI AVL - expertise applied to IORS staff)

Open-access research publications and presentations in scientific meetings

4.3 Writing and publishing open-access research articles (IORS - in collaboration with BRFAA, IDIBAPS/HCB and NKI)4.4 Preparing presentations for scientific meetings of the field (IORS - in collaboration with BRFAA, IDIBAPS/HCB and NKI)

Demonstrators, pilots, prototypes (1)

Establishment of a Research Management office at IORS

Form a Research Management Office at IORS by training IORS staff in specific management procedures and protocols (IORS - with expert advice from BRFAA, IDIBAPS/HCB and NKI)Train IORS staff on pre- and post-grant project management activities

Other (1)

Increasing professional capacities for omics analyses

2.4.Train IORS personnel for omics analyses (BRFAA, IDIBAPS/HCB and NKI expertise applied to IORS staff)

Publikacje

Thesis and dissertations (2)

Ispitivanje prognostičkih i prediktivnih kliničkih i molekularnih markera u lečenju lokalno uznapredovalog karcinoma rektuma neoadjuvantnom radiohemioterapijom primenom volumnog rotacionog planiranja zračne terapije i simultanog integrisanog boost-a

Autorzy: Marinkovic Mladen
Opublikowane w: 2024
Wydawca: Faculty of Medicine, University of Belgrade

Health economic evaluation of liquid biopsy in treatment decision management of patients with locally advanced rectal cancer in Serbia

Autorzy: Milena Cavic
Opublikowane w: 2025
Wydawca: Faculty of Medicine, University of Belgrade, Serbia
DOI: 10.5281/ZENODO.17769433

Conference proceedings (19)

Is there a relation between hematological toxicity and response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer?

Autorzy: Marinkovic M, Stojanović-Rundic S, Djurić A, Stanojevic A, Gavrilovic D, Jankovic R, Zoidakis J, Castellvi-Bel S, Fijneman R, Cavic M.
Opublikowane w: 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference : present and future of toxicology: challenges and opportunities: abstract book, Numer 1, 2023, ISBN 978-86-917867-3-1
Wydawca: Belgrade : [s.n.], 2023
DOI: 10.5281/ZENODO.17780517

Navigating ELSI for FAIR multiomics data management within STEPUPIORS international rectal cancer project

Autorzy: Tanić M, Bierkens M, Radulović M, Stanojević A, Marinković M, Krivokuća A, Janković R, Đurić A, Castellvi-Bel S, Zoidakis S, Fijneman R, Čavić M
Opublikowane w: Abstract book of the 5th Belgrade Bioinformatics Conference – BelBi2024, Numer 1, 2024
Wydawca: Belgrade Bioinformatics Conference, University of Belgrade
DOI: 10.5281/ZENODO.17799315

Employing widening EU funds to train the next generation of liquid biopsy researchers – example of the STEPUPIORS collaborative rectal cancer project

Autorzy: Cavic M, Djuric A, Marinkovic M, Stanojevic A, Tanic M, Damjanovic A, Spasic J, Bjelogrlic S, Djordjic Crnogorac M, Vuletic A, Mirjacic Martinovic K, Radulovic M, Stojanovic-Rundic S, Krivokuca A, Vuk
Opublikowane w: Abstract book of the EACR-AstraZeneca Conference: Circulating Nucleic Acids (cfDNA/ctDNA): In use, in view and on the horizon congress, Numer 1, 2025
Wydawca: European Association for Cancer Research
DOI: 10.5281/ZENODO.17818070

Prognostic factors for disease-free interval in patients with rectal cancer treated with neoadjuvant chemoradiotherapy and dose intensification

Autorzy: Marinković M, Stojanović-Rundić S, Stanojević A, Tomašević A, Janković R, Djurić A, Zoidakis J, Castellví-Bel S, Fijneman RJA, Čavić M.
Opublikowane w: Radiotherapy and Oncology, Numer 206 (Suppl. 1): 1223-1224., 2025, ISSN 0167-8140
Wydawca: European Society for Radiotherapy & Oncology
DOI: 10.5281/ZENODO.17818349

The Road from Human Sample Collections to the First Rectal Cancer Biobank at the Institute for Oncology and Radiology of Serbia

Autorzy: A. Djuric, M. Tanic, S. Bjelogrlic, S. StojanovicRundic, M. Marinkovic, A. Stanojevic, R. Fijenman, S. Castellví-Bel, J. Zoidakis, M. Cavic
Opublikowane w: Molecular Oncology, Numer 17 (Suppl. 1) (2023) 1–597. p464-465, 2023, ISSN 1574-7891
Wydawca: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13469

Employing widening funds to address inequity in cancer research - example of the STEPUPIORS collaborative rectal cancer project

Autorzy: Cavic M, Djuric A, Marinkovic M, Stanojevic A, Tanic M, Bjelogrlic S, Spasic J, Damjanovic A, Djordjic Crnogorac M, Vuletic A, Mirjacic Martinovic K, Radulovic M, Stojanovic-Rundic S, Krivokuca A, Ja
Opublikowane w: Cancer Research, Numer 84 (6_Supplement): 1304, 2024, ISSN 0008-5472
Wydawca: American Association for Cancer Research
DOI: 10.5281/ZENODO.17775214

Predicting response to chemoradiotherapy in locally advanced rectal cancer using MRI-based radiomics features

Autorzy: Marinković M, Stojanović-Rundić S, Stanojević A, Janković R, Zoidakis J, Castellvi-Bel S, J.A. Fijneman R, Čavić M, Radulovic M.
Opublikowane w: Oncology Insights, Numer 3009-3848, 2023
Wydawca: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795607

Expanding the Landscape of Professional Project Management to Support Cancer Research in Serbia.

Autorzy: Djuric A, Radulovic M, Damjanovic A, Fijneman R, Castellvi-Bel S, Zoidakis J, Cavic M.
Opublikowane w: Molecular Oncology, Numer Vol. 18. Supp. 1, 2024, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.5281/ZENODO.17780114

Novel 1-benzhydryl piperazine scaffold-based HDAC inhibitor b7 induces synergistic antiproliferative effect with vemurafenib in colorectal cancer cells harboring BRAF mutation.

Autorzy: Vuletic A, Mirjačić Martinović K, Srdić-Rajić T, Tišma Miletić N, Đurić A, Nikolić K, Ružić D, Čavić M.
Opublikowane w: Molecular Oncology, Numer 19 (S1): 160-161, 2025, ISSN 1574-7891
Wydawca: Elsevier BV
DOI: 10.5281/ZENODO.17775413

Correlation between genetic and proteomic expression of predictive biomarkers of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer identified by DIA mass spectrometry

Autorzy: A. Stefanovic, V. Lygirou, S. Stojanović-Rundić, R. Janković, S. Castellvi-Bel, R. J.A. Fijneman, A. Vlahou, J. Zoidakis, M. Samiotaki, M. Čavić
Opublikowane w: Molecular Oncology, Numer 17 (Suppl. 1) (2023) 1–597. p96-97, 2023, ISSN 1574-7891
Wydawca: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13469

International Collaborative Biobanking: Shaping the future together

Autorzy: Botta-Orfila T, Bjelogrlic S, Tanic M, Krivokuca A, Soler-Ventura A, Djuric A, Rodríguez-Vilarrupla A, Zoidakis J, Fijneman R, Castellví-Bel S, Cavic M.
Opublikowane w: Abstract book of the Europe Biobank Week Congress 2024, Numer 1, 2024
Wydawca: Europe Biobank Week Congress
DOI: 10.5281/ZENODO.17795879

Importance of Biobanks for Translational Cancer Research in Serbia.

Autorzy: Djuric A, Tanic M, Bjelogrlic S, Marinkovic M, Stanojevic A, Spasic J, Stojanovic-Rundic S, Jankovic R, Krivokuca A, Mirjacic Martinovic K, Vuletic A, Djordjic Crnogorac M, Damjanovic A, Radulovic M,
Opublikowane w: Proceedings of the 73rd Panhellenic Conference of the Hellenic Society of Biochemistry and Molecular Biology, Numer 1, 2023
Wydawca: Panhellenic Conference of the Hellenic Society of Biochemistry and Molecular Biology
DOI: 10.5281/ZENODO.17795787

Meta-analysis of publicly available transcriptomics data reveals predictive biomarkers for neoadjuvant chemoradiotherapy in rectal cancer

Autorzy: Stanojevic A, Stroggilos R, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Castellvi-Bel S, Fijneman R, Vlahou A, Zoidakis J, Cavic M.
Opublikowane w: Radiotherapy and Oncology, Numer Volume 206 (Suppl. 1): 4032-4033, 2025, ISSN 0167-8140
Wydawca: European Society for Radiotherapy & Oncology
DOI: 10.5281/ZENODO.17826580

Detection of viral proteins in locally advanced rectal cancer patient samples by mass spectrometry – predictive potential for response to neoadjuvant chemoradiotherapy.

Autorzy: Stanojević A, Samiotaki M, Lygirou V, Marinković M, Nikolić V, Stojanović-Rundić S, Janković R, Banko A, Miljanović D, Vlahou A, Panayotou G, J.A. Fijneman R, Castellvi-Bel S, Zoidakis J, Čavi
Opublikowane w: Oncology Insights, Numer 1, 2023, ISSN 3009-3848
Wydawca: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795659

The role of CEA and CA 19-9 tumor markers in predicting response to neoadjuvant radiochemotherapy in locally advanced rectal cancer

Autorzy: Marinković M, Stojanović-Rundić S, Stanojević A, Janković R, Zoidakis J, Castellvi-Bel S, Fijneman R, Čavić M.
Opublikowane w: Abstract book of the Third Serbian Radiation Oncology Congress, 2024
Wydawca: Oncology Institute of Vojvodina
DOI: 10.5281/ZENODO.17826664

Biobanking from Scratch: A Roadmap to Setup a Rectal Cancer Biobank Within the STEPUPIORS Project

Autorzy: Tanic M, Bjelogrlic S, Krivokuca A, Djuric A, Cavic M.
Opublikowane w: Abstract book of HDIR-7: Advances in Cancer Research & Treatment, Numer 1, 2024
Wydawca: Croatioan Association for Cancer Research
DOI: 10.5281/ZENODO.17817884

Initial absolute basophil, eosinophil and monocyte counts as potential predictive markers in locally advanced rectal cance

Autorzy: Marinković M, Stojanović-Rundić S, Stefanović A, Janković R, Zoidakis J., Castellvi-Bel S., Fijneman R., Cavic M
Opublikowane w: Abstract book of the 72th Annual Conference of the Hellenic Society of Biochemistry & Molecular Biology, Numer 11, 2022
Wydawca: 72 Hellenic Society of Biochemistry & Molecular Biology
DOI: 10.5281/ZENODO.17792526

Establishment of a first cancer Biobank at the Institute for Oncology and Radiology of Serbia –advantages, challenges and future perspective

Autorzy: Bjelogrlić S, Tanić M, Marinković M, Jelena Spasić S, Đurić S, Stojanović-Rundić S, Stanojević A, Đorđić Crnogorac M, Mirjačić Martinović K, Vuletić A, Damjanović Veličković A, Radu
Opublikowane w: Oncology Insights, Numer 1, 2023, ISSN 3009-3848
Wydawca: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795720

In-depth proteomic characterization of the response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer using data-independent acquisition mass spectrometry (DIA-MS)

Autorzy: Stefanović A, Lygirou V, Marinković M, Stojanović-Rundić S, Janković R, Vlahou A, Zoidakis J, Fijneman R., Castellvi-Bel S., Samiotaki M, Čavić M
Opublikowane w: 72th Annual Conference of the Hellenic Society of Biochemistry & Molecular Biology Abstract book, Numer 11, 2022
Wydawca: Hellenic Society of Biochemistry & Molecular Biology
DOI: 10.5281/ZENODO.17792610

Peer reviewed articles (7)

Methylenetetrahydrofolate reductase polymorphic variants C677T and A1298C in rectal cancer in Slavic population: significance for cancer risk and response to chemoradiotherapy

Autorzy: Stanojevic A, Spasic J, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Djuric A, Zoidakis J, Fijneman R.J.A, Castellvi-Bel S, Cavic M.
Opublikowane w: Frontier in Genetics, Numer 14, 2024, ISSN 1664-8021
Wydawca: Frontiers
DOI: 10.1101/2023.09.21.23295916

Exploring novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Autorzy: Marinkovic M, Stojanovic-Rundic S, Stanojevic A, Ostojic M, Gavrilovic D, Jankovic R, Maksimovic N, Stroggilos R, Zoidakis J, Castellví-Bel S, Fijneman RJA, Cavic M.
Opublikowane w: Frontier in Genetics, Numer 14, 2023, ISSN 1664-8021
Wydawca: Frontiers Media S.A.
DOI: 10.1101/2023.06.20.23291673

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer

Autorzy: Vuletic A, Mirjacic Martinovic K, Spasic J.
Opublikowane w: Pharmaceutics, Numer 16(1):54, 2023, ISSN 1999-4923
Wydawca: MDPI (Basel, Switzerland)
DOI: 10.20944/preprints202311.1805.v1

Performance and Dimensionality of Pretreatment MRI Radiomics in Rectal Carcinoma Chemoradiotherapy Prediction

Autorzy: Marinković, M.; Stojanović-Rundić, S.; Stanojevic, A.; Tomašević, A.; Janković, R.; Zoidakis, J.; Castellví-Bel, S.; Fijneman, R.J.; Čavić, M.; Radulović, M
Opublikowane w: Journal of Clinical Medicine, Numer 13(2):421, 2024, ISSN 2077-0383
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/preprints202310.0560.v1

Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy

Autorzy: Stanojevic A, Samiotaki M, Lygirou V, Marinkovic M, Nikolic V, Stojanovic-Rundic S, Jankovic R, Vlahou A, Panayotou G, Fijneman RJA, Castellví-Bel S, Zoidakis J, Cavic M
Opublikowane w: Int J Mol Sci, Numer 24(20), 2023, ISSN 1661-6596
Wydawca: MDPI (Basel, Switzerland)
DOI: 10.1101/2023.05.12.23289671

Two Decades of Progress in Personalized Medicine of Colorectal Cancer in Serbia—Insights from the Institute for Oncology and Radiology of Serbia

Autorzy: Milena Cavic, Neda Nikolic, Mladen Marinkovic, Ana Damjanovic, Ana Krivokuca, Miljana Tanic, Marko Radulovic, Aleksandra Stanojevic, Luka Pejnovic, Marija Djordjic Crnogorac, Ana Djuric, Miodrag Vukovic, Vanja Stevanovic, Jelena Kijac, Valentina Karadzic, Srdjan Nikolic, Suzana Stojanovic-Rundic, Radmila Jankovic, Jelena Spasic
Opublikowane w: Biomedicines, Numer 12, 2024, ISSN 2227-9059
Wydawca: MDPI AG
DOI: 10.3390/BIOMEDICINES12102278

Dose Escalation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Short-Term Efficacy and Toxicity of VMAT–SIB vs. 3D-CRT

Autorzy: Suzana Stojanovic-Rundic, Mladen Marinkovic, Aleksandra Stanojevic, Dusica Gavrilovic, Radmila Jankovic, Natasa Maksimovic, Aleksandar Tomasevic, Predrag Petrasinovic, Sandra Radenkovic, Milena Cavic
Opublikowane w: Medicina, Numer 61, 2025, ISSN 1648-9144
Wydawca: MDPI AG
DOI: 10.3390/MEDICINA61030483