TWINNING FOR A EUROPEAN CONSORTIUM OF RECTAL CANCER RESEARCH INSTITUTIONS THROUGH STEPPING UP SCIENTIFIC, TECHNOLOGICAL AND INNOVATION EXCELLENCE OF IORS

Información del proyecto

STEPUPIORS

Identificador del acuerdo de subvención: 101079217

DOI

10.3030/101079217

Proyecto cerrado

Fecha de la firma de la CE 14 Julio 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE
Serbia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Outreach activities

Transmitting results of the project to the general publicDesign IORS social networks Portal (IDIBAPS/HCB - in collaboration with IORS, BRFAA, NKI)Prepare outreach activities for the general public (IORS - with expert advice from BRFAA, IDIBAPS/HCB and NKI)

Documents, reports (5)

Midterm report of staff exchanges, expert visits to IORS and research proposals submitted

Research and administrative staff exchanges (IORS and BRFAA - in collaboration with IDIBAPS and NKI) Expert visits to IORS (BRFAA, IDIBAPS and NKI, one visit each)Remote virtual training on omics data analysis (BRFAA, IDIBAPS and NKI - expertise applied to IORS staff)Preparation and submission of research proposals with emphasis on MSCA doctoral networks and postdoctoral fellowships (BRFAA, IDIBAPS and NKI AVL - expertise applied to IORS staff)

Increased IORS human capacities for biobank management and oversight

1.4 Train IORS personnel for biobank management and oversight (IDIBAPS/HCB and NKI)

Teaching Materials and evaluation report for workshops and summer school

3.4 Workshops on omics approaches, skills for careers in academia/industry, and proposal writing (BRFAA, IDIBAPS and NKI expertise applied to IORS staff)3.5 Summer school on clinical applications of liquid biopsies (NKI - expertise applied to IORS staff)

Final report of staff exchanges, expert visits to IORS and research proposals submitted

Research and administrative staff exchanges (IORS and BRFAA - in collaboration with IDIBAPS and NKI) Expert visits to IORS (BRFAA, IDIBAPS and NKI, one visit each)Remote virtual training on omics data analysis (BRFAA, IDIBAPS and NKI - expertise applied to IORS staff)Preparation and submission of research proposals with emphasis on MSCA doctoral networks and postdoctoral fellowships (BRFAA, IDIBAPS and NKI AVL - expertise applied to IORS staff)

Open-access research publications and presentations in scientific meetings

4.3 Writing and publishing open-access research articles (IORS - in collaboration with BRFAA, IDIBAPS/HCB and NKI)4.4 Preparing presentations for scientific meetings of the field (IORS - in collaboration with BRFAA, IDIBAPS/HCB and NKI)

Demonstrators, pilots, prototypes (1)

Establishment of a Research Management office at IORS

Form a Research Management Office at IORS by training IORS staff in specific management procedures and protocols (IORS - with expert advice from BRFAA, IDIBAPS/HCB and NKI)Train IORS staff on pre- and post-grant project management activities

Other (1)

Increasing professional capacities for omics analyses

2.4.Train IORS personnel for omics analyses (BRFAA, IDIBAPS/HCB and NKI expertise applied to IORS staff)

Publicaciones

Thesis and dissertations (2)

Ispitivanje prognostičkih i prediktivnih kliničkih i molekularnih markera u lečenju lokalno uznapredovalog karcinoma rektuma neoadjuvantnom radiohemioterapijom primenom volumnog rotacionog planiranja zračne terapije i simultanog integrisanog boost-a

Autores: Marinkovic Mladen
Publicado en: 2024
Editor: Faculty of Medicine, University of Belgrade

Health economic evaluation of liquid biopsy in treatment decision management of patients with locally advanced rectal cancer in Serbia

Autores: Milena Cavic
Publicado en: 2025
Editor: Faculty of Medicine, University of Belgrade, Serbia
DOI: 10.5281/ZENODO.17769433

Peer reviewed articles (8)

Abstracts

Publicado en: Molecular Oncology, Edición 19, 2025, ISSN 1574-7891
Editor: Wiley
DOI: 10.1002/1878-0261.70070

Methylenetetrahydrofolate reductase polymorphic variants C677T and A1298C in rectal cancer in Slavic population: significance for cancer risk and response to chemoradiotherapy

Autores: Stanojevic A, Spasic J, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Djuric A, Zoidakis J, Fijneman R.J.A, Castellvi-Bel S, Cavic M.
Publicado en: Frontier in Genetics, Edición 14, 2024, ISSN 1664-8021
Editor: Frontiers
DOI: 10.1101/2023.09.21.23295916

Exploring novel genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Autores: Marinkovic M, Stojanovic-Rundic S, Stanojevic A, Ostojic M, Gavrilovic D, Jankovic R, Maksimovic N, Stroggilos R, Zoidakis J, Castellví-Bel S, Fijneman RJA, Cavic M.
Publicado en: Frontier in Genetics, Edición 14, 2023, ISSN 1664-8021
Editor: Frontiers Media S.A.
DOI: 10.1101/2023.06.20.23291673

Role of Histone Deacetylase 6 and Histone Deacetylase 6 Inhibition in Colorectal Cancer

Autores: Vuletic A, Mirjacic Martinovic K, Spasic J.
Publicado en: Pharmaceutics, Edición 16(1):54, 2023, ISSN 1999-4923
Editor: MDPI (Basel, Switzerland)
DOI: 10.20944/preprints202311.1805.v1

Performance and Dimensionality of Pretreatment MRI Radiomics in Rectal Carcinoma Chemoradiotherapy Prediction

Autores: Marinković, M.; Stojanović-Rundić, S.; Stanojevic, A.; Tomašević, A.; Janković, R.; Zoidakis, J.; Castellví-Bel, S.; Fijneman, R.J.; Čavić, M.; Radulović, M
Publicado en: Journal of Clinical Medicine, Edición 13(2):421, 2024, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.20944/preprints202310.0560.v1

Data-Independent Acquisition Mass Spectrometry Analysis of FFPE Rectal Cancer Samples Offers In-Depth Proteomics Characterization of the Response to Neoadjuvant Chemoradiotherapy

Autores: Stanojevic A, Samiotaki M, Lygirou V, Marinkovic M, Nikolic V, Stojanovic-Rundic S, Jankovic R, Vlahou A, Panayotou G, Fijneman RJA, Castellví-Bel S, Zoidakis J, Cavic M
Publicado en: Int J Mol Sci, Edición 24(20), 2023, ISSN 1661-6596
Editor: MDPI (Basel, Switzerland)
DOI: 10.1101/2023.05.12.23289671

Precision public health perspective: Is genomic population screening a viable option for the early detection of risks for oncological diseases? Reflections from Serbia

Autores: Bosiljka Đikanović, Janko Janković, Milena Čavić
Publicado en: Srpski medicinski casopis Lekarske komore, Edición 6, 2025, ISSN 2737-971X
Editor: Centre for Evaluation in Education and Science (CEON/CEES)
DOI: 10.5937/smclk6-57145

Dose Escalation in Neoadjuvant Chemoradiotherapy for Rectal Cancer: Short-Term Efficacy and Toxicity of VMAT–SIB vs. 3D-CRT

Autores: Suzana Stojanovic-Rundic, Mladen Marinkovic, Aleksandra Stanojevic, Dusica Gavrilovic, Radmila Jankovic, Natasa Maksimovic, Aleksandar Tomasevic, Predrag Petrasinovic, Sandra Radenkovic, Milena Cavic
Publicado en: Medicina, Edición 61, 2025, ISSN 1648-9144
Editor: MDPI AG
DOI: 10.3390/MEDICINA61030483

Conference proceedings (19)

Is there a relation between hematological toxicity and response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer?

Autores: Marinkovic M, Stojanović-Rundic S, Djurić A, Stanojevic A, Gavrilovic D, Jankovic R, Zoidakis J, Castellvi-Bel S, Fijneman R, Cavic M.
Publicado en: 13th International Congress of the Serbian Society of Toxicology and 1st TOXSEE Regional Conference : present and future of toxicology: challenges and opportunities: abstract book, Edición 1, 2023, ISBN 978-86-917867-3-1
Editor: Belgrade : [s.n.], 2023
DOI: 10.5281/ZENODO.17780517

Navigating ELSI for FAIR multiomics data management within STEPUPIORS international rectal cancer project

Autores: Tanić M, Bierkens M, Radulović M, Stanojević A, Marinković M, Krivokuća A, Janković R, Đurić A, Castellvi-Bel S, Zoidakis S, Fijneman R, Čavić M
Publicado en: Abstract book of the 5th Belgrade Bioinformatics Conference – BelBi2024, Edición 1, 2024
Editor: Belgrade Bioinformatics Conference, University of Belgrade
DOI: 10.5281/ZENODO.17799315

Employing widening EU funds to train the next generation of liquid biopsy researchers – example of the STEPUPIORS collaborative rectal cancer project

Autores: Cavic M, Djuric A, Marinkovic M, Stanojevic A, Tanic M, Damjanovic A, Spasic J, Bjelogrlic S, Djordjic Crnogorac M, Vuletic A, Mirjacic Martinovic K, Radulovic M, Stojanovic-Rundic S, Krivokuca A, Vuk
Publicado en: Abstract book of the EACR-AstraZeneca Conference: Circulating Nucleic Acids (cfDNA/ctDNA): In use, in view and on the horizon congress, Edición 1, 2025
Editor: European Association for Cancer Research
DOI: 10.5281/ZENODO.17818070

Prognostic factors for disease-free interval in patients with rectal cancer treated with neoadjuvant chemoradiotherapy and dose intensification

Autores: Marinković M, Stojanović-Rundić S, Stanojević A, Tomašević A, Janković R, Djurić A, Zoidakis J, Castellví-Bel S, Fijneman RJA, Čavić M.
Publicado en: Radiotherapy and Oncology, Edición 206 (Suppl. 1): 1223-1224., 2025, ISSN 0167-8140
Editor: European Society for Radiotherapy & Oncology
DOI: 10.5281/ZENODO.17818349

The Road from Human Sample Collections to the First Rectal Cancer Biobank at the Institute for Oncology and Radiology of Serbia

Autores: A. Djuric, M. Tanic, S. Bjelogrlic, S. StojanovicRundic, M. Marinkovic, A. Stanojevic, R. Fijenman, S. Castellví-Bel, J. Zoidakis, M. Cavic
Publicado en: Molecular Oncology, Edición 17 (Suppl. 1) (2023) 1–597. p464-465, 2023, ISSN 1574-7891
Editor: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13469

Employing widening funds to address inequity in cancer research - example of the STEPUPIORS collaborative rectal cancer project

Autores: Cavic M, Djuric A, Marinkovic M, Stanojevic A, Tanic M, Bjelogrlic S, Spasic J, Damjanovic A, Djordjic Crnogorac M, Vuletic A, Mirjacic Martinovic K, Radulovic M, Stojanovic-Rundic S, Krivokuca A, Ja
Publicado en: Cancer Research, Edición 84 (6_Supplement): 1304, 2024, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.5281/ZENODO.17775214

Predicting response to chemoradiotherapy in locally advanced rectal cancer using MRI-based radiomics features

Autores: Marinković M, Stojanović-Rundić S, Stanojević A, Janković R, Zoidakis J, Castellvi-Bel S, J.A. Fijneman R, Čavić M, Radulovic M.
Publicado en: Oncology Insights, Edición 3009-3848, 2023
Editor: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795607

Expanding the Landscape of Professional Project Management to Support Cancer Research in Serbia.

Autores: Djuric A, Radulovic M, Damjanovic A, Fijneman R, Castellvi-Bel S, Zoidakis J, Cavic M.
Publicado en: Molecular Oncology, Edición Vol. 18. Supp. 1, 2024, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.5281/ZENODO.17780114

Novel 1-benzhydryl piperazine scaffold-based HDAC inhibitor b7 induces synergistic antiproliferative effect with vemurafenib in colorectal cancer cells harboring BRAF mutation.

Autores: Vuletic A, Mirjačić Martinović K, Srdić-Rajić T, Tišma Miletić N, Đurić A, Nikolić K, Ružić D, Čavić M.
Publicado en: Molecular Oncology, Edición 19 (S1): 160-161, 2025, ISSN 1574-7891
Editor: Elsevier BV
DOI: 10.5281/ZENODO.17775413

Correlation between genetic and proteomic expression of predictive biomarkers of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer identified by DIA mass spectrometry

Autores: A. Stefanovic, V. Lygirou, S. Stojanović-Rundić, R. Janković, S. Castellvi-Bel, R. J.A. Fijneman, A. Vlahou, J. Zoidakis, M. Samiotaki, M. Čavić
Publicado en: Molecular Oncology, Edición 17 (Suppl. 1) (2023) 1–597. p96-97, 2023, ISSN 1574-7891
Editor: John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies
DOI: 10.1002/1878-0261.13469

International Collaborative Biobanking: Shaping the future together

Autores: Botta-Orfila T, Bjelogrlic S, Tanic M, Krivokuca A, Soler-Ventura A, Djuric A, Rodríguez-Vilarrupla A, Zoidakis J, Fijneman R, Castellví-Bel S, Cavic M.
Publicado en: Abstract book of the Europe Biobank Week Congress 2024, Edición 1, 2024
Editor: Europe Biobank Week Congress
DOI: 10.5281/ZENODO.17795879

Importance of Biobanks for Translational Cancer Research in Serbia.

Autores: Djuric A, Tanic M, Bjelogrlic S, Marinkovic M, Stanojevic A, Spasic J, Stojanovic-Rundic S, Jankovic R, Krivokuca A, Mirjacic Martinovic K, Vuletic A, Djordjic Crnogorac M, Damjanovic A, Radulovic M,
Publicado en: Proceedings of the 73rd Panhellenic Conference of the Hellenic Society of Biochemistry and Molecular Biology, Edición 1, 2023
Editor: Panhellenic Conference of the Hellenic Society of Biochemistry and Molecular Biology
DOI: 10.5281/ZENODO.17795787

Meta-analysis of publicly available transcriptomics data reveals predictive biomarkers for neoadjuvant chemoradiotherapy in rectal cancer

Autores: Stanojevic A, Stroggilos R, Marinkovic M, Stojanovic-Rundic S, Jankovic R, Castellvi-Bel S, Fijneman R, Vlahou A, Zoidakis J, Cavic M.
Publicado en: Radiotherapy and Oncology, Edición Volume 206 (Suppl. 1): 4032-4033, 2025, ISSN 0167-8140
Editor: European Society for Radiotherapy & Oncology
DOI: 10.5281/ZENODO.17826580

Detection of viral proteins in locally advanced rectal cancer patient samples by mass spectrometry – predictive potential for response to neoadjuvant chemoradiotherapy.

Autores: Stanojević A, Samiotaki M, Lygirou V, Marinković M, Nikolić V, Stojanović-Rundić S, Janković R, Banko A, Miljanović D, Vlahou A, Panayotou G, J.A. Fijneman R, Castellvi-Bel S, Zoidakis J, Čavi
Publicado en: Oncology Insights, Edición 1, 2023, ISSN 3009-3848
Editor: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795659

The role of CEA and CA 19-9 tumor markers in predicting response to neoadjuvant radiochemotherapy in locally advanced rectal cancer

Autores: Marinković M, Stojanović-Rundić S, Stanojević A, Janković R, Zoidakis J, Castellvi-Bel S, Fijneman R, Čavić M.
Publicado en: Abstract book of the Third Serbian Radiation Oncology Congress, 2024
Editor: Oncology Institute of Vojvodina
DOI: 10.5281/ZENODO.17826664

Biobanking from Scratch: A Roadmap to Setup a Rectal Cancer Biobank Within the STEPUPIORS Project

Autores: Tanic M, Bjelogrlic S, Krivokuca A, Djuric A, Cavic M.
Publicado en: Abstract book of HDIR-7: Advances in Cancer Research & Treatment, Edición 1, 2024
Editor: Croatioan Association for Cancer Research
DOI: 10.5281/ZENODO.17817884

Initial absolute basophil, eosinophil and monocyte counts as potential predictive markers in locally advanced rectal cance

Autores: Marinković M, Stojanović-Rundić S, Stefanović A, Janković R, Zoidakis J., Castellvi-Bel S., Fijneman R., Cavic M
Publicado en: Abstract book of the 72th Annual Conference of the Hellenic Society of Biochemistry & Molecular Biology, Edición 11, 2022
Editor: 72 Hellenic Society of Biochemistry & Molecular Biology
DOI: 10.5281/ZENODO.17792526

Establishment of a first cancer Biobank at the Institute for Oncology and Radiology of Serbia –advantages, challenges and future perspective

Autores: Bjelogrlić S, Tanić M, Marinković M, Jelena Spasić S, Đurić S, Stojanović-Rundić S, Stanojević A, Đorđić Crnogorac M, Mirjačić Martinović K, Vuletić A, Damjanović Veličković A, Radu
Publicado en: Oncology Insights, Edición 1, 2023, ISSN 3009-3848
Editor: Serbian Association for Cancer Research
DOI: 10.5281/ZENODO.17795720

In-depth proteomic characterization of the response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer using data-independent acquisition mass spectrometry (DIA-MS)

Autores: Stefanović A, Lygirou V, Marinković M, Stojanović-Rundić S, Janković R, Vlahou A, Zoidakis J, Fijneman R., Castellvi-Bel S., Samiotaki M, Čavić M
Publicado en: 72th Annual Conference of the Hellenic Society of Biochemistry & Molecular Biology Abstract book, Edición 11, 2022
Editor: Hellenic Society of Biochemistry & Molecular Biology
DOI: 10.5281/ZENODO.17792610