Twinning for Promoting Excellence, Ability and Knowledge to develop novel approaches for targeting inflammatory and degenerative age-related joint diseases

Información del proyecto

TWINFLAG

Identificador del acuerdo de subvención: 101079489

DOI

10.3030/101079489

Proyecto cerrado

Fecha de la firma de la CE 12 Agosto 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 30 Junio 2026

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 500 000,00

Aportación de la UE

€ 1 500 000,00

Coordinado por

VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS
Lithuania

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Plan for dissemination and exploitation activities

A plan for dissemination and exploitation including communication activities

Data Management Plan (1)

Data Management Plan

Data Management plan will be prepared (M6) and updated during the project.

Publicaciones

Peer reviewed articles (13)

Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format

Autores: Ursule Kalvaityte, Edvardas Bagdonas, Gailute Kirdaite, Asta Kausaite-Minkstimiene, Ilona Uzieliene, Almira Ramanaviciene, Anton Popov, Greta Butkiene, Vitalijus Karabanovas, Jaroslav Denkovskij, Ali Mobasheri, Eiva Bernotiene
Publicado en: International Journal of Nanomedicine, Edición Volume 20, 2025, ISSN 1178-2013
Editor: Informa UK Limited
DOI: 10.2147/IJN.S477118

Identification of Bone Marrow and Peripheral Blood Plasma Extracellular Vesicle Protein Biomarker Signatures for Multiple Myeloma Diagnosis and Staging

Autores: Angelique Cheryl, Rebecca Sheridan, Kieran Brennan, Despina Bazou, David Matallanas, Peter O'Gorman, Luis F Iglesias-Martinez, Margaret M Mc Gee
Publicado en: International Journal of Nanomedicine, Edición Volume 21, 2026, ISSN 1178-2013
Editor: Informa UK Limited
DOI: 10.2147/IJN.S576858

Effect of HIF-1α inhibitor LW6 on chondrogenic properties of mesenchymal stromal cells and chondrocytes in cell sheets under physioxia

Autores: Ignas Lebedis, Jolita Pachaleva, Eiva Bernotiene, Daiva Bironaite, Tomas Ragauskas, Giedrius Kvedaras, Gunaras Terbetas, Ilona Uzieliene
Publicado en: Journal of Biological Engineering, Edición 20, 2026, ISSN 1754-1611
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S13036-025-00588-8

Potential of MSCA1 for isolating osteogenic cells in a chondrocyte population

Autores: Ausra Unguryte, Ilona Uzieliene, Edvardas Bagdonas, Aiste Zentelyte, Narūnas Porvaneckas, Eiva Bernotiene
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-91303-6

The Effect of TGF-β3 and IL-1β on L-Type Voltage-Operated Calcium Channels and Calcium Ion Homeostasis in Osteoarthritic Chondrocytes and Human Bone Marrow-Derived Mesenchymal Stem Cells During Chondrogenesis

Autores: Anastasiia Shelest, Aidas Alaburda, Raminta Vaiciuleviciute, Ilona Uzieliene, Paulina Bialaglovyte, Eiva Bernotiene
Publicado en: Pharmaceutics, Edición 17, 2025, ISSN 1999-4923
Editor: MDPI AG
DOI: 10.3390/PHARMACEUTICS17030343

Signal-driven interplay between lipid peroxidation and ferroptosis orchestrates osteoarthritis degeneration

Autores: Md.F. Kulyar, Jolita Pachaleva, Sandra Brazaite, Muhammad Akhtar, Mohammad Mehedi Hasan, Saeed Kaboli, Ignas Lebedis, Eiva Bernotiene
Publicado en: Journal of Orthopaedic Translation, Edición 60, 2026, ISSN 2214-031X
Editor: Elsevier BV
DOI: 10.1016/J.JOT.2026.101178

Modeling the Effect of Annulus Fibrosus Stiffness on the Stressed State of a Vertebral L1 Body and Nucleus Pulposus

Autores: Oleg Ardatov, Jolita Pachaleva, Viktorija Aleksiuk, Algirdas Maknickas, Ilona Uzieliene, Raminta Vaiciuleviciute, Eiva Bernotiene
Publicado en: Bioengineering, Edición 11, 2025, ISSN 2306-5354
Editor: MDPI AG
DOI: 10.3390/BIOENGINEERING11040305

Electrical Stimulation in Cartilage Tissue Engineering

Autores: Raminta Vaiciuleviciute, Ilona Uzieliene, Paulius Bernotas, Vitalij Novickij, Aidas Alaburda, Eiva Bernotiene
Publicado en: Bioengineering, Edición 10, 2025, ISSN 2306-5354
Editor: MDPI AG
DOI: 10.3390/BIOENGINEERING10040454

Extracellular vesicles in the heart: mediators of intercellular communication in health and disease in vitro

Autores: Raminta Vaiciuleviciute, Mario Schubert, Kaomei Guan, Eiva Bernotiene
Publicado en: Cell Communication and Signaling, Edición 24, 2026, ISSN 1478-811X
Editor: Springer Science and Business Media LLC
DOI: 10.1186/S12964-026-02866-4

Clinical Applications of Extracellular Vesicles: Promises and Pitfalls

Autores: Dragan Primorac, Petar Brlek, Luka Bulić, Nenad Hrvatin, Vedrana Škaro, Petar Projić, Martina Glavan, Ijeoma Oleru, Pierre Rocheteau, Carlo Tremolada, Ariana DeMers, Mary A. Ambach, Don Buford, Tamara Knežević, Dimitrios Kouroupis, Cole Conforti, D. Wood Kimbrough, R. Peter Schnorr, Lindsay Williams, Raminta Vaiciuleviciute, Žan Fortuna, Lara Oprešnik, Blaž Curk, Miomir Knežević, Gordana Kalan Živčec, Adelina Hrkać, Dimitrios Tsoukas, Ilona Uzieliene, Jolita Pachaleva, Eiva Bernotiene, Kristiana Barbato, Neep Patel, Isabella Demirdjian Guanche, Evangelos V. Badiavas, Jana Mešić, Ana Medić Flajšman, Romina Milanič, Danijela Klarić, Vasiliki E. Kalodimou, Massimo Allegri, Johannes Brachmann, Wei Seong Toh, Nancy Duarte Delgado, Ali Mobasheri
Publicado en: International Journal of Molecular Sciences, Edición 27, 2026, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS27031509

The Challenges of Local Intra-Articular Therapy

Autores: Gailute Kirdaite, Jaroslav Denkovskij, Diana Mieliauskaite, Jolita Pachaleva, Eiva Bernotiene
Publicado en: Medicina, Edición 60, 2025, ISSN 1648-9144
Editor: MDPI AG
DOI: 10.3390/MEDICINA60111819

Identification of Extracellular Vesicle Signatures of Daratumumab Treated Multiple Myeloma

Autores: Kieran Brennan, Katrine F. Iversen, Alfonso Blanco‐Fernández, Thomas Lund, Torben Plesner, Margaret M. Mc Gee
Publicado en: Journal of Extracellular Vesicles, Edición 15, 2026, ISSN 2001-3078
Editor: Wiley
DOI: 10.1002/JEV2.70213

Therapeutic Potential of Extracellular Vesicles: From Biogenesis, Isolation and Molecular Characterization to Addressing Translational Gaps and Regulatory Barriers

Autores: Dragan Primorac, Petar Brlek, Luka Bulić, Nenad Hrvatin, Vedrana Škaro, Petar Projić, Martina Glavan, Ijeoma Oleru, Pierre Rocheteau, Carlo Tremolada, Ariana DeMers, Mary A. Ambach, Don Buford, Tamara Knežević, Dimitrios Kouroupis, Cole Conforti, D. Wood Kimbrough, R. Peter Schnorr, Lindsay Williams, Raminta Vaiciuleviciute, Žan Fortuna, Lara Oprešnik, Blaž Curk, Miomir Knežević, Gordana Kalan Živčec, Adelina Hrkać, Dimitrios Tsoukas, Ilona Uzieliene, Jolita Pachaleva, Eiva Bernotiene, Kristiana Barbato, Neep Patel, Isabella Demirdjian Guanche, Evangelos V. Badiavas, Jana Mešić, Ana Medić Flajšman, Romina Milanič, Danijela Klarić, Vasiliki E. Kalodimou, Massimo Allegri, Johannes Brachmann, Wei Seong Toh, Nancy Duarte Delgado, Ali Mobasheri
Publicado en: International Journal of Molecular Sciences, Edición 27, 2026, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS27041676

Other (1)

Advancing Nano-Flow Cytometry: High-Precision Sorting and Analysis of Extracellular Vesicles

Autores: Irene Castrosín, Vanessa Costa, Brandy Pickney, Ionita Ghiran, Kieran Brennan, Flor Delgado, César Reyes-Pérez, K Jensen, Alfonso Blanco, John Tigges, Margaret Mc Gee
Publicado en: 2026
Editor: openRxiv
DOI: 10.64898/2026.07.27.741001